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Protein
Submitted name:

E3 ubiquitin-protein ligase Mdm2

Gene

mdm2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
E3 ubiquitin-protein ligase Mdm2Imported
Submitted name:
Mdm2Imported
Gene namesi
Name:mdm2Imported
Synonyms:MDM2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000135679.21.
HGNCiHGNC:6973. MDM2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000135679.

PTM / Processingi

Proteomic databases

MaxQBiA7UKX8.

Expressioni

Gene expression databases

BgeeiENSG00000135679.
ExpressionAtlasiA7UKX8. baseline and differential.

Structurei

3D structure databases

SMRiA7UKX8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 95SWIBInterPro annotationAdd BLAST67

Phylogenomic databases

GeneTreeiENSGT00530000063539.
HOVERGENiHBG013472.

Family and domain databases

Gene3Di1.10.245.10. 1 hit.
InterProiView protein in InterPro
IPR015459. MDM2_E3_ligase.
IPR016495. p53_neg-reg_MDM_2/4.
IPR003121. SWIB_MDM2_domain.
PANTHERiPTHR13844:SF33. PTHR13844:SF33. 1 hit.
PfamiView protein in Pfam
PF02201. SWIB. 1 hit.
PIRSFiPIRSF006748. p53_MDM_2/4. 2 hits.
SUPFAMiSSF47592. SSF47592. 1 hit.

Sequencei

Sequence statusi: Fragment.

A7UKX8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCNTNMSVPT DGAVTTSQIP ASEQETLVRP KPLLLKLLKS VGAQKDTYTM
60 70 80 90 100
KEVLFYLGQY IMTKRLYDEK QQHIVYCSND LLGDLFGVPS FSVKEHRKIY
110 120 130 140 150
TMIYRNLVVV NQQESSDSGT SVSENRCHLE GGSDQKDLVQ ELQEEKPSSS
160 170 180 190 200
HLVSRPSTSS RRRAISETEE NSDELSGERQ RKRHKSDSIS LSFDESLALC
210 220 230 240 250
VIREICCERS SSSESTGTPS NPDLDAGVYQ VTVYQAGESD TDSFEEDPEI

SLADYW
Length:256
Mass (Da):28,730
Last modified:October 2, 2007 - v1
Checksum:i680FB46549DE2469
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei256Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC025423 Genomic DNA. No translation available.
EU076747 mRNA. Translation: ABT17084.1.
RefSeqiNP_001138809.1. NM_001145337.2.
UniGeneiHs.484551.
Hs.733536.

Genome annotation databases

EnsembliENST00000393415; ENSP00000377067; ENSG00000135679.
GeneIDi4193.
UCSCiuc058qrn.1. human.

Similar proteinsi

Entry informationi

Entry nameiA7UKX8_HUMAN
AccessioniPrimary (citable) accession number: A7UKX8
Secondary accession number(s): E7EPE3
Entry historyiIntegrated into UniProtKB/TrEMBL: October 2, 2007
Last sequence update: October 2, 2007
Last modified: September 27, 2017
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported