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Protein
Submitted name:

E3 ubiquitin-protein ligase Mdm2

Gene

mdm2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
E3 ubiquitin-protein ligase Mdm2Imported
Submitted name:
Mdm2Imported
Gene namesi
Name:mdm2Imported
Synonyms:MDM2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:6973. MDM2.

PTM / Processingi

Proteomic databases

PaxDbiA7UKX7.

PTM databases

iPTMnetiA7UKX7.

Expressioni

Gene expression databases

BgeeiA7UKX7.
ExpressionAtlasiA7UKX7. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000417281.

Structurei

3D structure databases

ProteinModelPortaliA7UKX7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IGXG. Eukaryota.
ENOG41125MP. LUCA.
GeneTreeiENSGT00530000063539.
HOVERGENiHBG093712.

Family and domain databases

Gene3Di1.10.245.10. 1 hit.
InterProiIPR015459. MDM2_E3_ligase.
IPR003121. SWIB_MDM2_domain.
[Graphical view]
PANTHERiPTHR13844:SF15. PTHR13844:SF15. 1 hit.
SUPFAMiSSF47592. SSF47592. 1 hit.

Sequencei

Sequence statusi: Fragment.

A7UKX7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCNTNMSVPT DGAVTTSQIP ASEQETLVRP KPLLLKLLKS VGAQKDTYTM
60 70 80 90 100
KEDLDAGVSE HSGDWLDQDS VSDQFSVEFE VESLDSEDYS LSEEGQELSD
110
EDDEDYWKCT SCNEMNPP
Length:118
Mass (Da):13,133
Last modified:October 2, 2007 - v1
Checksum:i2A82DE153A1189FF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei118 – 1181Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC025423 Genomic DNA. No translation available.
EU076746 mRNA. Translation: ABT17083.1.
RefSeqiNP_001138812.1. NM_001145340.2.
UniGeneiHs.484551.
Hs.733536.

Genome annotation databases

EnsembliENST00000543323; ENSP00000439238; ENSG00000135679.
GeneIDi4193.
UCSCiuc058qrp.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC025423 Genomic DNA. No translation available.
EU076746 mRNA. Translation: ABT17083.1.
RefSeqiNP_001138812.1. NM_001145340.2.
UniGeneiHs.484551.
Hs.733536.

3D structure databases

ProteinModelPortaliA7UKX7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000417281.

PTM databases

iPTMnetiA7UKX7.

Proteomic databases

PaxDbiA7UKX7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000543323; ENSP00000439238; ENSG00000135679.
GeneIDi4193.
UCSCiuc058qrp.1. human.

Organism-specific databases

CTDi4193.
HGNCiHGNC:6973. MDM2.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGXG. Eukaryota.
ENOG41125MP. LUCA.
GeneTreeiENSGT00530000063539.
HOVERGENiHBG093712.

Miscellaneous databases

ChiTaRSiMDM2. human.
GenomeRNAii4193.
NextBioi27032308.

Gene expression databases

BgeeiA7UKX7.
ExpressionAtlasiA7UKX7. baseline and differential.

Family and domain databases

Gene3Di1.10.245.10. 1 hit.
InterProiIPR015459. MDM2_E3_ligase.
IPR003121. SWIB_MDM2_domain.
[Graphical view]
PANTHERiPTHR13844:SF15. PTHR13844:SF15. 1 hit.
SUPFAMiSSF47592. SSF47592. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The finished DNA sequence of human chromosome 12."
    Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A., null.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Disruption of the p53-Mdm2 complex by nutlin-3 reveals different cancer cell phenotypes."
    Arva N.C., Talbott K.E., Okoro D.R., Qiu W., Bargonetti J.
    Ethn. Dis. 0:0-0(2007)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: P2-MDM2-C1Imported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiA7UKX7_HUMAN
AccessioniPrimary (citable) accession number: A7UKX7
Secondary accession number(s): A0A0A6YYM9, A0A0K0K1B6, F6RKA8
Entry historyi
Integrated into UniProtKB/TrEMBL: October 2, 2007
Last sequence update: October 2, 2007
Last modified: March 16, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.