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Protein

Carboxypeptidase S1 homolog A

Gene

SCPA

Organism
Trichophyton equinum (Horse ringworm fungus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Extracellular serine carboxypeptidase that contributes to pathogenicity.By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei238PROSITE-ProRule annotation1
Active sitei458PROSITE-ProRule annotation1
Binding sitei461SubstrateBy similarity1
Active sitei516PROSITE-ProRule annotation1
Binding sitei517SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Protease
Biological processVirulence

Protein family/group databases

ESTHERitrieq-spca. Carboxypeptidase_S10.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase S1 homolog A (EC:3.4.16.6)
Alternative name(s):
Serine carboxypeptidase A
Short name:
SPCA
Gene namesi
Name:SCPA
OrganismiTrichophyton equinum (Horse ringworm fungus)
Taxonomic identifieri63418 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeTrichophyton

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000038411520 – 629Carboxypeptidase S1 homolog AAdd BLAST610
PropeptideiPRO_0000384116630 – 652Removed in mature formSequence analysisAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi50 ↔ 121By similarity
Glycosylationi77N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi132N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi161N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi168N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi184N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi202N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi260N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi299N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi325 ↔ 361By similarity
Disulfide bondi332 ↔ 354By similarity
Glycosylationi347N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi410N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi474N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi492N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi505N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi629GPI-anchor amidated glycineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Structurei

3D structure databases

ProteinModelPortaliA7UKV5.
SMRiA7UKV5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiView protein in InterPro
IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Ser_caboxypep_ser_AS.
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiView protein in Pfam
PF00450. Peptidase_S10. 1 hit.
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 2 hits.
PROSITEiView protein in PROSITE
PS00131. CARBOXYPEPT_SER_SER. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A7UKV5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFAASIAVA LPVIGAASAQ GFPPPVEGVT VVKSKFDENV KITYKENDIC
60 70 80 90 100
ETTEGVRSFT GHVHLPPDDN DFGVYRNYSI NTFFWFFEAR EDPKNAPLSI
110 120 130 140 150
WLNGGPGSSS MIGLFQENGP CWINDDSKST TNNTFSWNNK VNMLYIDQPN
160 170 180 190 200
QVGFSYDELT NITYSTINDT VYVADFSNGV PAQNLSTLVG TGSSQNPWAT
210 220 230 240 250
ANNTVNAARS IWHFAQVWFQ EFPEHKPNNN KISIWTESYG GRYGPSFASY
260 270 280 290 300
FQEQNEKIKN HTITEEGEMH ILNLDTLGII NGCIDLMFQA ESYAEFPYNN
310 320 330 340 350
TYGITAYTKE KYDAIIHDIH RPDGCFDKLA KCREAAKEGD PHFYSNNATV
360 370 380 390 400
NAICADASSS CDNYLMDPYQ ETNLGYYDIA HPLQDPFPPP FYKGFLSQSS
410 420 430 440 450
VLSDMGSPVN FTQYAQAVGK SFHGVGDYAR PDVRGFTGDI AYLLESGVKV
460 470 480 490 500
ALVYGDRDYI CNWIGGEQVS LGLNYTGTAE FHRAGYADVK VNSSYVGGLV
510 520 530 540 550
RQHGNFSFTR VFEAGHEVPG YQPETSLKIF ERIMFNKDIA TGELDIAQKP
560 570 580 590 600
DYGTTGTEST FQVKNEIPPS PEPTCYLLSA DGTCTQEQLK AIKEGTAVVE
610 620 630 640 650
NYIIKSPAAS KGDPPPTTTT SPTAAPTAGS AMLQAPVAML AISVLTALAF

FL
Length:652
Mass (Da):71,739
Last modified:October 2, 2007 - v1
Checksum:i2840A00CAC4FEE03
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU076570 Genomic DNA. Translation: ABU50380.1.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiSPCA_TRIEQ
AccessioniPrimary (citable) accession number: A7UKV5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: October 2, 2007
Last modified: May 10, 2017
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families