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Protein

Glial cell line-derived neurotrophic factor

Gene

Gdnf

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.UniRule annotation

Keywords - Molecular functioni

Growth factorUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Glial cell line-derived neurotrophic factorUniRule annotation
Gene namesi
Name:GdnfImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi2677. Gdnf.

Subcellular locationi

  • Secreted UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

SecretedUniRule annotationSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 211192Glial cell line-derived neurotrophic factorSequence analysisPRO_5007636504Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

Subunit structurei

Homodimer; disulfide-linked.UniRule annotation

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000044012.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini88 – 211124TGF_BETA_2InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TGF-beta family. GDNF subfamily.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IGT5. Eukaryota.
ENOG4111I3D. LUCA.
HOVERGENiHBG106680.
KOiK05452.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR016649. GDNF.
IPR001839. TGF-b_C.
[Graphical view]
PfamiPF00019. TGF_beta. 1 hit.
[Graphical view]
PIRSFiPIRSF016238. GDNF. 1 hit.
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7UGJ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLWDVVAVC LVLLHTASAF PLPAGKRLLE APAEDHSLGH RRVPFALTSD
60 70 80 90 100
SNMPEDYPDQ FDDVMDFIQA TIKRLKRSPD KQAAALPRRE RNRQAAAASP
110 120 130 140 150
ENSRGKGRRG QRGKNRGCVL TAIHLNVTDL GLGYETKEEL IFRYCSGSCE
160 170 180 190 200
AAETMYDKIL KNLSRSRRLT SDKVGQACCR PVAFDDDLSF LDDSLVYHIL
210
RKHSAKRCGC I
Length:211
Mass (Da):23,619
Last modified:October 2, 2007 - v1
Checksum:iAE06C646682895A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU068469 mRNA. Translation: ABU49426.1.
EU068471 mRNA. Translation: ABU49428.1.
EU068472 mRNA. Translation: ABU49429.1.
RefSeqiNP_062012.1. NM_019139.1.
UniGeneiRn.53970.

Genome annotation databases

GeneIDi25453.
KEGGirno:25453.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU068469 mRNA. Translation: ABU49426.1.
EU068471 mRNA. Translation: ABU49428.1.
EU068472 mRNA. Translation: ABU49429.1.
RefSeqiNP_062012.1. NM_019139.1.
UniGeneiRn.53970.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000044012.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25453.
KEGGirno:25453.

Organism-specific databases

CTDi2668.
RGDi2677. Gdnf.

Phylogenomic databases

eggNOGiENOG410IGT5. Eukaryota.
ENOG4111I3D. LUCA.
HOVERGENiHBG106680.
KOiK05452.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR016649. GDNF.
IPR001839. TGF-b_C.
[Graphical view]
PfamiPF00019. TGF_beta. 1 hit.
[Graphical view]
PIRSFiPIRSF016238. GDNF. 1 hit.
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Alginate-matrigel microencapsulated schwann cells for inducible secretion of glial cell line derived neurotrophic factor."
    de Guzman R.C., Ereifej E.S., Broadrick K.M., Rogers R.A., VandeVord P.J.
    J. Microencapsul. 25:487-498(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiA7UGJ1_RAT
AccessioniPrimary (citable) accession number: A7UGJ1
Entry historyi
Integrated into UniProtKB/TrEMBL: October 2, 2007
Last sequence update: October 2, 2007
Last modified: July 6, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.