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Protein

Glial cell line-derived neurotrophic factor

Gene

Gdnf

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionGrowth factorUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Glial cell line-derived neurotrophic factorUniRule annotation
Gene namesi
Name:GdnfImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi2677 Gdnf

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedUniRule annotationSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_501010361120 – 211Glial cell line-derived neurotrophic factorSequence analysisAdd BLAST192

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

Subunit structurei

Homodimer; disulfide-linked.UniRule annotation

GO - Molecular functioni

Structurei

3D structure databases

SMRiA7UGJ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini88 – 211TGF_BETA_2InterPro annotationAdd BLAST124

Sequence similaritiesi

Belongs to the TGF-beta family. GDNF subfamily.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IGT5 Eukaryota
ENOG4111I3D LUCA
HOVERGENiHBG106680
KOiK05452

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR016649 GDNF
IPR001839 TGF-b_C
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PIRSFiPIRSF016238 GDNF, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS51362 TGF_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

A7UGJ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLWDVVAVC LVLLHTASAF PLPAGKRLLE APAEDHSLGH RRVPFALTSD
60 70 80 90 100
SNMPEDYPDQ FDDVMDFIQA TIKRLKRSPD KQAAALPRRE RNRQAAAASP
110 120 130 140 150
ENSRGKGRRG QRGKNRGCVL TAIHLNVTDL GLGYETKEEL IFRYCSGSCE
160 170 180 190 200
AAETMYDKIL KNLSRSRRLT SDKVGQACCR PVAFDDDLSF LDDSLVYHIL
210
RKHSAKRCGC I
Length:211
Mass (Da):23,619
Last modified:October 2, 2007 - v1
Checksum:iAE06C646682895A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU068469 mRNA Translation: ABU49426.1
EU068471 mRNA Translation: ABU49428.1
EU068472 mRNA Translation: ABU49429.1
RefSeqiNP_062012.1, NM_019139.1
UniGeneiRn.53970

Genome annotation databases

GeneIDi25453
KEGGirno:25453

Similar proteinsi

Entry informationi

Entry nameiA7UGJ1_RAT
AccessioniPrimary (citable) accession number: A7UGJ1
Entry historyiIntegrated into UniProtKB/TrEMBL: October 2, 2007
Last sequence update: October 2, 2007
Last modified: March 28, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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