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A7TZU4 (ENP1_ENCIN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 11, 2011. Version 6. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Spore wall and anchoring disk complex protein EnP1
Alternative name(s):
Host cell adhesion protein EnP1
Gene names
Name:EnP1
OrganismEncephalitozoon intestinalis (Microsporidian parasite)
Taxonomic identifier58839 [NCBI]
Taxonomic lineageEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon

Protein attributes

Sequence length348 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existencePredicted

General annotation (Comments)

Function

Spore wall protein involved in the adhesion to host cells surface glycoaminoglycans (GAGs). Microsporidian spore adherence is an integral part of activation and host cell infection. Ref.1

Subcellular location

Spore wall. Spore wallperispore. Note: Localizes also at the anchoring disk complex which consists of the polar sac and the anchoring disk, playing a crucial role in the rupture of the spore wall and the subsequent release of the polar tube following activation. Ref.1

Domain

Heparin-binding motifs (HBM) are characterized by an XBBXBX or XBBBXXBX sequence, where X is any neutral amino acid and B is a positively charged basic amino acid, and are defined as the consensus sequence necessary for protein-heparin interactions. HBM motifs may be involved in spore adherence to host cells. Ref.1

Ontologies

Keywords
   Biological processCell adhesion
Sporulation
   DomainSignal
   PTMGlycoprotein
Gene Ontology (GO)
   Biological_processcell adhesion

Inferred from electronic annotation. Source: UniProtKB-KW

sporulation resulting in formation of a cellular spore

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentspore wall

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616 Potential
Chain17 – 348332Spore wall and anchoring disk complex protein EnP1
PRO_0000377524

Regions

Motif193 – 1986HBM1
Motif248 – 2569HBM2
Motif322 – 3276HBM3

Amino acid modifications

Glycosylation471N-linked (GlcNAc...) Potential
Glycosylation1391N-linked (GlcNAc...) Potential
Glycosylation1401N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
A7TZU4 [UniParc].

Last modified October 2, 2007. Version 1.
Checksum: 13694D713A5FA4A2

FASTA34839,101
        10         20         30         40         50         60 
MKLLGLLISA FGAINALKIK ALYLSCDYEL RPYNAVIDSQ CMAFALNGSN IHEAIRYLNA 

        70         80         90        100        110        120 
MNIDKAYVLY WNDHDLHQNP MVLHKNGALA PFDRYTNTAK HVLCVEACSC PGPQSRPVVC 

       130        140        150        160        170        180 
PENNGASVSS PCPPCGQGNN TTVCDKVVVN PQPVKPLPAP CTPCAPCESS SSEKSESKEC 

       190        200        210        220        230        240 
MTFPRICKKK CGPRHGRSPK KVEIVKSQKT YTFDIERYKR RGDVVVRVCS QDCKDKFEKF 

       250        260        270        280        290        300 
VLTKTGEIRK GKDKKCIPEP LPECLQCPKN LYKLKSGIEA KVCSEVCMYI NSKCEIFVLI 

       310        320        330        340 
GDCDFYKVVM NERRRKQSSF HLKKIRGQKL RELIRQGLFG VEFSPLKC 

« Hide

References

[1]"EnP1, a microsporidian spore wall protein that enables spores to adhere to and infect host cells in vitro."
Southern T.R., Jolly C.E., Lester M.E., Hayman J.R.
Eukaryot. Cell 6:1354-1362(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], DOMAIN, SUBCELLULAR LOCATION, FUNCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
EF539266 Genomic DNA. Translation: ABU24317.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

ProtoNetSearch...

Entry information

Entry nameENP1_ENCIN
AccessionPrimary (citable) accession number: A7TZU4
Entry history
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: October 2, 2007
Last modified: January 11, 2011
This is version 6 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program