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A7TZU4

- ENP1_ENCIN

UniProt

A7TZU4 - ENP1_ENCIN

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Protein

Spore wall and anchoring disk complex protein EnP1

Gene

EnP1

Organism
Encephalitozoon intestinalis (Microsporidian parasite)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Spore wall protein involved in the adhesion to host cells surface glycoaminoglycans (GAGs). Microsporidian spore adherence is an integral part of activation and host cell infection.1 Publication

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. sporulation resulting in formation of a cellular spore Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Sporulation

Names & Taxonomyi

Protein namesi
Recommended name:
Spore wall and anchoring disk complex protein EnP1
Alternative name(s):
Host cell adhesion protein EnP1
Gene namesi
Name:EnP1
OrganismiEncephalitozoon intestinalis (Microsporidian parasite)
Taxonomic identifieri58839 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon

Subcellular locationi

Spore wall 1 Publication. Spore wallperispore 1 Publication
Note: Localizes also at the anchoring disk complex which consists of the polar sac and the anchoring disk, playing a crucial role in the rupture of the spore wall and the subsequent release of the polar tube following activation.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence AnalysisAdd
BLAST
Chaini17 – 348332Spore wall and anchoring disk complex protein EnP1PRO_0000377524Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi47 – 471N-linked (GlcNAc...)Sequence Analysis
Glycosylationi139 – 1391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi140 – 1401N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi193 – 1986HBM1
Motifi248 – 2569HBM2
Motifi322 – 3276HBM3

Domaini

Heparin-binding motifs (HBM) are characterized by an XBBXBX or XBBBXXBX sequence, where X is any neutral amino acid and B is a positively charged basic amino acid, and are defined as the consensus sequence necessary for protein-heparin interactions. HBM motifs may be involved in spore adherence to host cells.1 Publication

Keywords - Domaini

Signal

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A7TZU4-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MKLLGLLISA FGAINALKIK ALYLSCDYEL RPYNAVIDSQ CMAFALNGSN
60 70 80 90 100
IHEAIRYLNA MNIDKAYVLY WNDHDLHQNP MVLHKNGALA PFDRYTNTAK
110 120 130 140 150
HVLCVEACSC PGPQSRPVVC PENNGASVSS PCPPCGQGNN TTVCDKVVVN
160 170 180 190 200
PQPVKPLPAP CTPCAPCESS SSEKSESKEC MTFPRICKKK CGPRHGRSPK
210 220 230 240 250
KVEIVKSQKT YTFDIERYKR RGDVVVRVCS QDCKDKFEKF VLTKTGEIRK
260 270 280 290 300
GKDKKCIPEP LPECLQCPKN LYKLKSGIEA KVCSEVCMYI NSKCEIFVLI
310 320 330 340
GDCDFYKVVM NERRRKQSSF HLKKIRGQKL RELIRQGLFG VEFSPLKC
Length:348
Mass (Da):39,101
Last modified:October 2, 2007 - v1
Checksum:i13694D713A5FA4A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF539266 Genomic DNA. Translation: ABU24317.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF539266 Genomic DNA. Translation: ABU24317.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "EnP1, a microsporidian spore wall protein that enables spores to adhere to and infect host cells in vitro."
    Southern T.R., Jolly C.E., Lester M.E., Hayman J.R.
    Eukaryot. Cell 6:1354-1362(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], DOMAIN, SUBCELLULAR LOCATION, FUNCTION.

Entry informationi

Entry nameiENP1_ENCIN
AccessioniPrimary (citable) accession number: A7TZU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: October 2, 2007
Last modified: October 29, 2014
This is version 8 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program