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A7TZU4

- ENP1_ENCIN

UniProt

A7TZU4 - ENP1_ENCIN

Protein

Spore wall and anchoring disk complex protein EnP1

Gene

EnP1

Organism
Encephalitozoon intestinalis (Microsporidian parasite)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 7 (01 Oct 2014)
      Sequence version 1 (02 Oct 2007)
      Previous versions | rss
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    Functioni

    Spore wall protein involved in the adhesion to host cells surface glycoaminoglycans (GAGs). Microsporidian spore adherence is an integral part of activation and host cell infection.1 Publication

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW
    2. sporulation resulting in formation of a cellular spore Source: UniProtKB-KW

    Keywords - Biological processi

    Cell adhesion, Sporulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Spore wall and anchoring disk complex protein EnP1
    Alternative name(s):
    Host cell adhesion protein EnP1
    Gene namesi
    Name:EnP1
    OrganismiEncephalitozoon intestinalis (Microsporidian parasite)
    Taxonomic identifieri58839 [NCBI]
    Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon

    Subcellular locationi

    Spore wall 1 Publication. Spore wallperispore 1 Publication
    Note: Localizes also at the anchoring disk complex which consists of the polar sac and the anchoring disk, playing a crucial role in the rupture of the spore wall and the subsequent release of the polar tube following activation.

    GO - Cellular componenti

    1. spore wall Source: UniProtKB-SubCell

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Sequence AnalysisAdd
    BLAST
    Chaini17 – 348332Spore wall and anchoring disk complex protein EnP1PRO_0000377524Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi47 – 471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi139 – 1391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi140 – 1401N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi193 – 1986HBM1
    Motifi248 – 2569HBM2
    Motifi322 – 3276HBM3

    Domaini

    Heparin-binding motifs (HBM) are characterized by an XBBXBX or XBBBXXBX sequence, where X is any neutral amino acid and B is a positively charged basic amino acid, and are defined as the consensus sequence necessary for protein-heparin interactions. HBM motifs may be involved in spore adherence to host cells.1 Publication

    Keywords - Domaini

    Signal

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A7TZU4-1 [UniParc]FASTAAdd to Basket

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    MKLLGLLISA FGAINALKIK ALYLSCDYEL RPYNAVIDSQ CMAFALNGSN    50
    IHEAIRYLNA MNIDKAYVLY WNDHDLHQNP MVLHKNGALA PFDRYTNTAK 100
    HVLCVEACSC PGPQSRPVVC PENNGASVSS PCPPCGQGNN TTVCDKVVVN 150
    PQPVKPLPAP CTPCAPCESS SSEKSESKEC MTFPRICKKK CGPRHGRSPK 200
    KVEIVKSQKT YTFDIERYKR RGDVVVRVCS QDCKDKFEKF VLTKTGEIRK 250
    GKDKKCIPEP LPECLQCPKN LYKLKSGIEA KVCSEVCMYI NSKCEIFVLI 300
    GDCDFYKVVM NERRRKQSSF HLKKIRGQKL RELIRQGLFG VEFSPLKC 348
    Length:348
    Mass (Da):39,101
    Last modified:October 2, 2007 - v1
    Checksum:i13694D713A5FA4A2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF539266 Genomic DNA. Translation: ABU24317.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF539266 Genomic DNA. Translation: ABU24317.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "EnP1, a microsporidian spore wall protein that enables spores to adhere to and infect host cells in vitro."
      Southern T.R., Jolly C.E., Lester M.E., Hayman J.R.
      Eukaryot. Cell 6:1354-1362(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], DOMAIN, SUBCELLULAR LOCATION, FUNCTION.

    Entry informationi

    Entry nameiENP1_ENCIN
    AccessioniPrimary (citable) accession number: A7TZU4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 16, 2009
    Last sequence update: October 2, 2007
    Last modified: October 1, 2014
    This is version 7 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program