ID   A7TVK4_TAKRU            Unreviewed;       410 AA.
AC   A7TVK4;
DT   02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT   02-OCT-2007, sequence version 1.
DT   27-MAR-2024, entry version 81.
DE   RecName: Full=exo-alpha-sialidase {ECO:0000256|ARBA:ARBA00012733};
DE            EC=3.2.1.18 {ECO:0000256|ARBA:ARBA00012733};
GN   Name=neu3 {ECO:0000313|Ensembl:ENSTRUP00000047871.1};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|EMBL:ABQ62950.1};
RN   [1] {ECO:0000313|EMBL:ABQ62950.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=17708749; DOI=10.1042/BJ20070627;
RA   Manzoni M., Colombi P., Papini N., Rubaga L., Tiso N., Preti A.,
RA   Venerando B., Tettamanti G., Bresciani R., Argenton F., Borsani G.,
RA   Monti E.;
RT   "Molecular cloning and biochemical characterization of sialidases from
RT   zebrafish (Danio rerio).";
RL   Biochem. J. 408:395-406(2007).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000047871.1, ECO:0000313|Proteomes:UP000005226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA   Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu facilitates
RT   insights into distinct features of genome evolution in teleosts and
RT   mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [3] {ECO:0000313|Ensembl:ENSTRUP00000047871.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-
CC         (2->8)- glycosidic linkages of terminal sialic acid residues in
CC         oligosaccharides, glycoproteins, glycolipids, colominic acid and
CC         synthetic substrates.; EC=3.2.1.18;
CC         Evidence={ECO:0000256|ARBA:ARBA00000427};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 33 family.
CC       {ECO:0000256|ARBA:ARBA00009348}.
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DR   EMBL; EF434605; ABQ62950.1; -; Genomic_DNA.
DR   RefSeq; XP_003971311.1; XM_003971262.2.
DR   RefSeq; XP_011609881.1; XM_011611579.1.
DR   RefSeq; XP_011609882.1; XM_011611580.1.
DR   STRING; 31033.ENSTRUP00000047871; -.
DR   CAZy; GH33; Glycoside Hydrolase Family 33.
DR   Ensembl; ENSTRUT00000053996.2; ENSTRUP00000047871.1; ENSTRUG00000022280.2.
DR   GeneID; 101078624; -.
DR   KEGG; tru:101078624; -.
DR   CTD; 10825; -.
DR   GeneTree; ENSGT00950000182944; -.
DR   OMA; ECGIKRE; -.
DR   OrthoDB; 5482010at2759; -.
DR   Proteomes; UP000005226; Chromosome 15.
DR   GO; GO:0052794; F:exo-alpha-(2->3)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052795; F:exo-alpha-(2->6)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052796; F:exo-alpha-(2->8)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF23; SIALIDASE-3; 1.
DR   Pfam; PF13088; BNR_2; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   3: Inferred from homology;
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022963};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226}.
FT   DOMAIN          55..369
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13088"
SQ   SEQUENCE   410 AA;  45959 MW;  E5083D621A8642C3 CRC64;
     MGNSPSKSAS GEEPVKTTLF EREPDGITYR IPALIYLRHS HTFLAFAEKR SSPSDCDAKN
     LVMRRGTLKD DGSVQWSTSQ ELSVACLPNH RVMNPCPVYE KNSKTLFLFF ICVWRHTTEW
     RQILTGKNKT RLCCATSTDD GQTWSPAKDL TESTIGEAVR RWATFAVGPG HGVQLENGRL
     IIPAYAYYIP YRCFSIPIPF TVCPRALSVY SEDFGQTWHI GKMLSKKSCE CEMAEIIDHE
     GRSHLYCNAR NSGGHRCEAL SENSGLYFDK PHIAPELIEP PSGCQGSVIG FPAPEFIPND
     EADSKACGTS LLSPDTQTWL LFIHPTNKSS RRDMGVYLNR SPLHSSGWDR PRIIHRGPSG
     YSDLAYNGDK DQFSCLMECG KESELEQIAF TSFTLNDVMQ TGSKKDKKMR
//