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A7TTQ1

- MSH3_VANPO

UniProt

A7TTQ1 - MSH3_VANPO

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Protein

DNA mismatch repair protein MSH3

Gene

MSH3

Organism
Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi792 – 7998ATPSequence Analysis

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. mismatched DNA binding Source: InterPro

GO - Biological processi

  1. mismatch repair Source: InterPro
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA mismatch repair protein MSH3
Alternative name(s):
MutS protein homolog 3
Gene namesi
Name:MSH3
ORF Names:Kpol_183p2
OrganismiVanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)
Taxonomic identifieri436907 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeVanderwaltozyma
ProteomesiUP000000267: Unassembled WGS sequence

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10231023DNA mismatch repair protein MSH3PRO_0000338532Add
BLAST

Interactioni

Subunit structurei

Heterodimer consisting of MSH2-MSH3 (MutS beta). Forms a ternary complex with MutL alpha (MLH1-PMS1) (By similarity).By similarity

Protein-protein interaction databases

STRINGi436907.A7TTQ1.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni129 – 259131Mispair-binding domainBy similarityAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0249.
InParanoidiA7TTQ1.
KOiK08736.
OrthoDBiEOG773XQH.

Family and domain databases

Gene3Di3.40.1170.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR016151. DNA_mismatch_repair_MutS_N.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view]
SMARTiSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view]
SUPFAMiSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF55271. SSF55271. 1 hit.
PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7TTQ1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKQPVISRF FKPIARKEVT SEKGVEKEKP VDLDEEKHNE PATTSRLMPK
60 70 80 90 100
GFDAAAETVT DEVIEIEVEI EHESEPKIEI KNGTVTAENK SMDFAEKLNR
110 120 130 140 150
IWNDKKRVIS NNDNDDSDGE NDTIVKKSKN NSNKLTPLDQ QVKDLKLLHM
160 170 180 190 200
DKILVIRVGY KYKCFAQDAE IVSKILHIML IPGKLTIDES NPQDSNYRQF
210 220 230 240 250
AYCSFPDIRL KVHLETLVHN NLKVAVVEQS ETSAIKKNSN ASSKNSVFER
260 270 280 290 300
KISGVYTKAT FGINSAFSSN RKNVLGQYNS IWIINFSEID KINSSFFMIS
310 320 330 340 350
VNLNSGEIIY DTFECSTTSI ENLETRIKYL NPIEVLTVSA LPEKVKLRLH
360 370 380 390 400
GSNSTILLKE KEDIDKEIME EINKSTKGLN LSAELFELVP VLYKYLTEYN
410 420 430 440 450
NEELLLISEN YKPFASKKHM VLNAAAIESL GIFGEEGGKG SLFWLLDHTR
460 470 480 490 500
TSFGSRKLRE WILHPLLDKK EIEDRLDAVD CIIHEVSNIF FESLNKMLTN
510 520 530 540 550
VPDLLRTINR IAYGTTSRKE IYYFLKQMKS FSDHFQLHSN YLNSQVVSND
560 570 580 590 600
GRIHKSSALL TNLLTEITSG LKEINIENIL SMINVSSVME KDTYKQVSEF
610 620 630 640 650
FNLNYYDHAE EIIKIQGNIN EVKNELAEEL SSIRKILKRP HLNYKDEMDY
660 670 680 690 700
LIEVRNTQTK GLPSDWIVVN RTKMISRYHT PTSRKLIEKL QYQKDILYQE
710 720 730 740 750
TQKEYFQFVK RIKNDYFALN KIINHIATYD CILALASTSQ NMNYVRPVLT
760 770 780 790 800
DESQFIDAKN ARNPIIESLD INYVPNDVNL SHSAGKFLII TGPNMGGKSS
810 820 830 840 850
YIRQVALLVI LAQVGSYVPA DFMKTSIFDK ILTRIGAYDN LLKGQSTFKV
860 870 880 890 900
ELLEIQNIIK NKTENSLLLL DEVGRGTSTE DGKAISYSIV DYFINLPVCP
910 920 930 940 950
LVLFTTHYPF LGSINSKILK SYYMDFVEQK KEGEDWPSIV FLYKLRSGIT
960 970 980 990 1000
DSSFGLNVAR LAQIDKDIIN HAFSISEKIR QETETANTMN LPILLKHILS
1010 1020
SNDLKPQQKI IEILNLQNDS QEL
Length:1,023
Mass (Da):117,059
Last modified:October 2, 2007 - v1
Checksum:i2A1A7FF99F8FA1D4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS480605 Genomic DNA. Translation: EDO14357.1.
RefSeqiXP_001642215.1. XM_001642165.1.

Genome annotation databases

GeneIDi5542335.
KEGGivpo:Kpol_183p2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS480605 Genomic DNA. Translation: EDO14357.1 .
RefSeqi XP_001642215.1. XM_001642165.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 436907.A7TTQ1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5542335.
KEGGi vpo:Kpol_183p2.

Phylogenomic databases

eggNOGi COG0249.
InParanoidi A7TTQ1.
KOi K08736.
OrthoDBi EOG773XQH.

Family and domain databases

Gene3Di 3.40.1170.10. 1 hit.
3.40.50.300. 1 hit.
InterProi IPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR016151. DNA_mismatch_repair_MutS_N.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view ]
SMARTi SM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view ]
SUPFAMi SSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF55271. SSF55271. 1 hit.
PROSITEi PS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Independent sorting-out of thousands of duplicated gene pairs in two yeast species descended from a whole-genome duplication."
    Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.
    Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 22028 / DSM 70294.

Entry informationi

Entry nameiMSH3_VANPO
AccessioniPrimary (citable) accession number: A7TTQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: October 2, 2007
Last modified: October 29, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3