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A7TTQ1

- MSH3_VANPO

UniProt

A7TTQ1 - MSH3_VANPO

Protein

DNA mismatch repair protein MSH3

Gene

MSH3

Organism
Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (02 Oct 2007)
      Previous versions | rss
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    Functioni

    Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi792 – 7998ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. mismatched DNA binding Source: InterPro

    GO - Biological processi

    1. mismatch repair Source: InterPro

    Keywords - Biological processi

    DNA damage, DNA repair

    Keywords - Ligandi

    ATP-binding, DNA-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA mismatch repair protein MSH3
    Alternative name(s):
    MutS protein homolog 3
    Gene namesi
    Name:MSH3
    ORF Names:Kpol_183p2
    OrganismiVanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)
    Taxonomic identifieri436907 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeVanderwaltozyma
    ProteomesiUP000000267: Unassembled WGS sequence

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10231023DNA mismatch repair protein MSH3PRO_0000338532Add
    BLAST

    Interactioni

    Subunit structurei

    Heterodimer consisting of MSH2-MSH3 (MutS beta). Forms a ternary complex with MutL alpha (MLH1-PMS1) By similarity.By similarity

    Protein-protein interaction databases

    STRINGi436907.A7TTQ1.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni129 – 259131Mispair-binding domainBy similarityAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0249.
    KOiK08736.
    OrthoDBiEOG773XQH.

    Family and domain databases

    Gene3Di3.40.1170.10. 1 hit.
    3.40.50.300. 1 hit.
    InterProiIPR007695. DNA_mismatch_repair_MutS-lik_N.
    IPR000432. DNA_mismatch_repair_MutS_C.
    IPR007861. DNA_mismatch_repair_MutS_clamp.
    IPR007696. DNA_mismatch_repair_MutS_core.
    IPR016151. DNA_mismatch_repair_MutS_N.
    IPR007860. DNA_mmatch_repair_MutS_con_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01624. MutS_I. 1 hit.
    PF05188. MutS_II. 1 hit.
    PF05192. MutS_III. 1 hit.
    PF05190. MutS_IV. 1 hit.
    PF00488. MutS_V. 1 hit.
    [Graphical view]
    SMARTiSM00534. MUTSac. 1 hit.
    SM00533. MUTSd. 1 hit.
    [Graphical view]
    SUPFAMiSSF48334. SSF48334. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF55271. SSF55271. 1 hit.
    PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A7TTQ1-1 [UniParc]FASTAAdd to Basket

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    MSKQPVISRF FKPIARKEVT SEKGVEKEKP VDLDEEKHNE PATTSRLMPK     50
    GFDAAAETVT DEVIEIEVEI EHESEPKIEI KNGTVTAENK SMDFAEKLNR 100
    IWNDKKRVIS NNDNDDSDGE NDTIVKKSKN NSNKLTPLDQ QVKDLKLLHM 150
    DKILVIRVGY KYKCFAQDAE IVSKILHIML IPGKLTIDES NPQDSNYRQF 200
    AYCSFPDIRL KVHLETLVHN NLKVAVVEQS ETSAIKKNSN ASSKNSVFER 250
    KISGVYTKAT FGINSAFSSN RKNVLGQYNS IWIINFSEID KINSSFFMIS 300
    VNLNSGEIIY DTFECSTTSI ENLETRIKYL NPIEVLTVSA LPEKVKLRLH 350
    GSNSTILLKE KEDIDKEIME EINKSTKGLN LSAELFELVP VLYKYLTEYN 400
    NEELLLISEN YKPFASKKHM VLNAAAIESL GIFGEEGGKG SLFWLLDHTR 450
    TSFGSRKLRE WILHPLLDKK EIEDRLDAVD CIIHEVSNIF FESLNKMLTN 500
    VPDLLRTINR IAYGTTSRKE IYYFLKQMKS FSDHFQLHSN YLNSQVVSND 550
    GRIHKSSALL TNLLTEITSG LKEINIENIL SMINVSSVME KDTYKQVSEF 600
    FNLNYYDHAE EIIKIQGNIN EVKNELAEEL SSIRKILKRP HLNYKDEMDY 650
    LIEVRNTQTK GLPSDWIVVN RTKMISRYHT PTSRKLIEKL QYQKDILYQE 700
    TQKEYFQFVK RIKNDYFALN KIINHIATYD CILALASTSQ NMNYVRPVLT 750
    DESQFIDAKN ARNPIIESLD INYVPNDVNL SHSAGKFLII TGPNMGGKSS 800
    YIRQVALLVI LAQVGSYVPA DFMKTSIFDK ILTRIGAYDN LLKGQSTFKV 850
    ELLEIQNIIK NKTENSLLLL DEVGRGTSTE DGKAISYSIV DYFINLPVCP 900
    LVLFTTHYPF LGSINSKILK SYYMDFVEQK KEGEDWPSIV FLYKLRSGIT 950
    DSSFGLNVAR LAQIDKDIIN HAFSISEKIR QETETANTMN LPILLKHILS 1000
    SNDLKPQQKI IEILNLQNDS QEL 1023
    Length:1,023
    Mass (Da):117,059
    Last modified:October 2, 2007 - v1
    Checksum:i2A1A7FF99F8FA1D4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS480605 Genomic DNA. Translation: EDO14357.1.
    RefSeqiXP_001642215.1. XM_001642165.1.

    Genome annotation databases

    GeneIDi5542335.
    KEGGivpo:Kpol_183p2.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS480605 Genomic DNA. Translation: EDO14357.1 .
    RefSeqi XP_001642215.1. XM_001642165.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 436907.A7TTQ1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5542335.
    KEGGi vpo:Kpol_183p2.

    Phylogenomic databases

    eggNOGi COG0249.
    KOi K08736.
    OrthoDBi EOG773XQH.

    Family and domain databases

    Gene3Di 3.40.1170.10. 1 hit.
    3.40.50.300. 1 hit.
    InterProi IPR007695. DNA_mismatch_repair_MutS-lik_N.
    IPR000432. DNA_mismatch_repair_MutS_C.
    IPR007861. DNA_mismatch_repair_MutS_clamp.
    IPR007696. DNA_mismatch_repair_MutS_core.
    IPR016151. DNA_mismatch_repair_MutS_N.
    IPR007860. DNA_mmatch_repair_MutS_con_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01624. MutS_I. 1 hit.
    PF05188. MutS_II. 1 hit.
    PF05192. MutS_III. 1 hit.
    PF05190. MutS_IV. 1 hit.
    PF00488. MutS_V. 1 hit.
    [Graphical view ]
    SMARTi SM00534. MUTSac. 1 hit.
    SM00533. MUTSd. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48334. SSF48334. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF55271. SSF55271. 1 hit.
    PROSITEi PS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Independent sorting-out of thousands of duplicated gene pairs in two yeast species descended from a whole-genome duplication."
      Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.
      Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 22028 / DSM 70294.

    Entry informationi

    Entry nameiMSH3_VANPO
    AccessioniPrimary (citable) accession number: A7TTQ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: October 2, 2007
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3