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A7TTQ1

- MSH3_VANPO

UniProt

A7TTQ1 - MSH3_VANPO

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Protein
DNA mismatch repair protein MSH3
Gene
MSH3, Kpol_183p2
Organism
Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi792 – 7998ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. mismatched DNA binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. mismatch repair Source: InterPro
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA mismatch repair protein MSH3
Alternative name(s):
MutS protein homolog 3
Gene namesi
Name:MSH3
ORF Names:Kpol_183p2
OrganismiVanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)
Taxonomic identifieri436907 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeVanderwaltozyma
ProteomesiUP000000267: Unassembled WGS sequence

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10231023DNA mismatch repair protein MSH3
PRO_0000338532Add
BLAST

Interactioni

Subunit structurei

Heterodimer consisting of MSH2-MSH3 (MutS beta). Forms a ternary complex with MutL alpha (MLH1-PMS1) By similarity.

Protein-protein interaction databases

STRINGi436907.A7TTQ1.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni129 – 259131Mispair-binding domain By similarity
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0249.
KOiK08736.
OrthoDBiEOG773XQH.

Family and domain databases

Gene3Di3.40.1170.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR016151. DNA_mismatch_repair_MutS_N.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view]
SMARTiSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view]
SUPFAMiSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF55271. SSF55271. 1 hit.
PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7TTQ1-1 [UniParc]FASTAAdd to Basket

« Hide

MSKQPVISRF FKPIARKEVT SEKGVEKEKP VDLDEEKHNE PATTSRLMPK     50
GFDAAAETVT DEVIEIEVEI EHESEPKIEI KNGTVTAENK SMDFAEKLNR 100
IWNDKKRVIS NNDNDDSDGE NDTIVKKSKN NSNKLTPLDQ QVKDLKLLHM 150
DKILVIRVGY KYKCFAQDAE IVSKILHIML IPGKLTIDES NPQDSNYRQF 200
AYCSFPDIRL KVHLETLVHN NLKVAVVEQS ETSAIKKNSN ASSKNSVFER 250
KISGVYTKAT FGINSAFSSN RKNVLGQYNS IWIINFSEID KINSSFFMIS 300
VNLNSGEIIY DTFECSTTSI ENLETRIKYL NPIEVLTVSA LPEKVKLRLH 350
GSNSTILLKE KEDIDKEIME EINKSTKGLN LSAELFELVP VLYKYLTEYN 400
NEELLLISEN YKPFASKKHM VLNAAAIESL GIFGEEGGKG SLFWLLDHTR 450
TSFGSRKLRE WILHPLLDKK EIEDRLDAVD CIIHEVSNIF FESLNKMLTN 500
VPDLLRTINR IAYGTTSRKE IYYFLKQMKS FSDHFQLHSN YLNSQVVSND 550
GRIHKSSALL TNLLTEITSG LKEINIENIL SMINVSSVME KDTYKQVSEF 600
FNLNYYDHAE EIIKIQGNIN EVKNELAEEL SSIRKILKRP HLNYKDEMDY 650
LIEVRNTQTK GLPSDWIVVN RTKMISRYHT PTSRKLIEKL QYQKDILYQE 700
TQKEYFQFVK RIKNDYFALN KIINHIATYD CILALASTSQ NMNYVRPVLT 750
DESQFIDAKN ARNPIIESLD INYVPNDVNL SHSAGKFLII TGPNMGGKSS 800
YIRQVALLVI LAQVGSYVPA DFMKTSIFDK ILTRIGAYDN LLKGQSTFKV 850
ELLEIQNIIK NKTENSLLLL DEVGRGTSTE DGKAISYSIV DYFINLPVCP 900
LVLFTTHYPF LGSINSKILK SYYMDFVEQK KEGEDWPSIV FLYKLRSGIT 950
DSSFGLNVAR LAQIDKDIIN HAFSISEKIR QETETANTMN LPILLKHILS 1000
SNDLKPQQKI IEILNLQNDS QEL 1023
Length:1,023
Mass (Da):117,059
Last modified:October 2, 2007 - v1
Checksum:i2A1A7FF99F8FA1D4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS480605 Genomic DNA. Translation: EDO14357.1.
RefSeqiXP_001642215.1. XM_001642165.1.

Genome annotation databases

GeneIDi5542335.
KEGGivpo:Kpol_183p2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS480605 Genomic DNA. Translation: EDO14357.1 .
RefSeqi XP_001642215.1. XM_001642165.1.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 436907.A7TTQ1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5542335.
KEGGi vpo:Kpol_183p2.

Phylogenomic databases

eggNOGi COG0249.
KOi K08736.
OrthoDBi EOG773XQH.

Family and domain databases

Gene3Di 3.40.1170.10. 1 hit.
3.40.50.300. 1 hit.
InterProi IPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR016151. DNA_mismatch_repair_MutS_N.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view ]
SMARTi SM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view ]
SUPFAMi SSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF55271. SSF55271. 1 hit.
PROSITEi PS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Independent sorting-out of thousands of duplicated gene pairs in two yeast species descended from a whole-genome duplication."
    Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.
    Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 22028 / DSM 70294.

Entry informationi

Entry nameiMSH3_VANPO
AccessioniPrimary (citable) accession number: A7TTQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: October 2, 2007
Last modified: June 11, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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