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A7TSL2

- PMIP_VANPO

UniProt

A7TSL2 - PMIP_VANPO

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Protein

Mitochondrial intermediate peptidase

Gene
OCT1, Kpol_297p8
Organism
Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Binds 1 zinc ion By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi573 – 5731Zinc; catalytic By similarity
Active sitei574 – 5741 By similarity
Metal bindingi577 – 5771Zinc; catalytic By similarity
Metal bindingi580 – 5801Zinc; catalytic By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metalloendopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM03.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:OCT1
ORF Names:Kpol_297p8
OrganismiVanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)
Taxonomic identifieri436907 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeVanderwaltozyma
ProteomesiUP000000267: Unassembled WGS sequence

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3636Mitochondrion Reviewed predictionAdd
BLAST
Chaini37 – 787751Mitochondrial intermediate peptidasePRO_0000338596Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi436907.A7TSL2.

Structurei

3D structure databases

ProteinModelPortaliA7TSL2.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M3 family.

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0339.
KOiK01410.
OrthoDBiEOG71GB4R.

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A7TSL2-1 [UniParc]FASTAAdd to Basket

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MQNKVLRGIL FKNVPLGYSY NRSIRHPTFG NSIIRWASTQ VKTSSDVLQR    50
SFDDHLYWTE INKQNYSSKE GWGSITKRLK GNKLTTNRSG LFNNEYLTSP 100
EGLKLFSQVS LEKSQKIVDK LRSDRTPEGL RLYVQNLDLL SDTLCRVIDL 150
CEFIRSSHPD YKFVEAAQDC YEEMFEFMNM LNTDVNLCFT LKHVLENKEI 200
ASKLSEEELR VGRILLEDFE KSGIYMKPEV REQFITLSQS ISVIGQEFIS 250
NTDFVKDNNV VVSCNQLDSL GIDPELLSQI EKDIAGKNYK IPTYGYIPFA 300
LLKSCPSEEI REKIWVAVHN CSNEQIKRLT DLVKLRAVLS QLLGKKSYAE 350
YQLEGKMAKN PKEVIEFIKT LMDFTKPMAA KELDGIAEKK LTIKSNGSNL 400
SVCDILKTVR PWDRDYYSAI EREQTSAKNL YGSEEVLKYF TLGNVMQGLS 450
NLFQKIYGIK LELDVPKIGE TWSPEVRKIN VISEDEGLIG IIYCDLFERS 500
GKTSNAAHFT ICCSRDISPY ETEDSTTQIA IDSKGTRFQL PIISLVCNFS 550
KTMISETDSV CFLHLPEVET LFHEMGHAMH SMLGRTKLQN ISGTRCATDF 600
VELPSILMEY FARDPRVLET IGKHYLTKET VKREMLEPHL QDLKYLQHCE 650
TYSQAKMAML DQTLHGETIS SHLDHLDVVK LYQDLERQLG VLVDDKSNWC 700
GKFGHLFGYS AVYYSYLFDR AIASKIWGAL FERNPFSRAS GDKYRNSVLQ 750
WGGSRDPWHC IASALDKPEL AKGDDEAIKY IGSTNQL 787
Length:787
Mass (Da):90,031
Last modified:October 2, 2007 - v1
Checksum:i478D339F977CF096
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS480515 Genomic DNA. Translation: EDO14747.1.
RefSeqiXP_001642605.1. XM_001642555.1.

Genome annotation databases

GeneIDi5542774.
KEGGivpo:Kpol_297p8.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS480515 Genomic DNA. Translation: EDO14747.1 .
RefSeqi XP_001642605.1. XM_001642555.1.

3D structure databases

ProteinModelPortali A7TSL2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 436907.A7TSL2.

Protein family/group databases

MEROPSi M03.006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5542774.
KEGGi vpo:Kpol_297p8.

Phylogenomic databases

eggNOGi COG0339.
KOi K01410.
OrthoDBi EOG71GB4R.

Family and domain databases

Gene3Di 1.10.1370.10. 2 hits.
3.40.390.10. 1 hit.
InterProi IPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view ]
Pfami PF01432. Peptidase_M3. 1 hit.
[Graphical view ]
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Independent sorting-out of thousands of duplicated gene pairs in two yeast species descended from a whole-genome duplication."
    Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.
    Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 22028 / DSM 70294.

Entry informationi

Entry nameiPMIP_VANPO
AccessioniPrimary (citable) accession number: A7TSL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: October 2, 2007
Last modified: May 14, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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