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Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei196 – 1961PROSITE-ProRule annotation
Active sitei404 – 4041PROSITE-ProRule annotation
Active sitei468 – 4681PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
ORF Names:Kpol_1041p46
OrganismiVanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)
Taxonomic identifieri436907 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeVanderwaltozyma
ProteomesiUP000000267 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 616594LumenalSequence AnalysisAdd
BLAST
Transmembranei617 – 63721HelicalSequence AnalysisAdd
BLAST
Topological domaini638 – 71376CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 713691Pheromone-processing carboxypeptidase KEX1PRO_0000411951Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi457 – 4571N-linked (GlcNAc...)Sequence Analysis
Glycosylationi465 – 4651N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi436907.XP_001644846.1.

Structurei

3D structure databases

ProteinModelPortaliA7TLB3.
SMRiA7TLB3. Positions 24-505.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi554 – 59946Poly-AspAdd
BLAST
Compositional biasi651 – 6599Poly-Ser

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2939.
InParanoidiA7TLB3.
KOiK01288.
OrthoDBiEOG7TJ3SJ.
PhylomeDBiA7TLB3.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A7TLB3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMVSYKLLSL ITLLFVAQCT TGLLKQDDYV VRPDLLPGIS SIKDKALIPK
60 70 80 90 100
MYAGHIPLNL QKTTDENENT DESDSNSNTN YFFWKFQHQS VESPNLIFWL
110 120 130 140 150
NGGPGCSSMD GALVETGPFR VDKNGKLYPN EGSWHSRGDL VYIDQPIGTG
160 170 180 190 200
LSTSAAIPNL LDDLKEVSDN FILFLENYFT IFPNDLDKDI IIAGESYAGQ
210 220 230 240 250
YIPFFAKAIK EYNQKISDNK KKINLRMLLI GNGWIDPITQ SLSYLPFAIE
260 270 280 290 300
KNLVGKDTPD FETLLKAHEK CQNKINSISE DDNSFSHEEC ESIINMLVSV
310 320 330 340 350
TKDNSPNVKS NEVCINIYDF NLRDSFPACG ANWPIDVSHV AKFFSTPGVI
360 370 380 390 400
EALNLNAEEV PRWKECNYDV LNHLTNPVSK PSVRLLPELL ESGIEIILFN
410 420 430 440 450
GENDLVCNNK GITDMISKLT WNGATGFSDK VQKYEWLFRD LTKDTEEPAG
460 470 480 490 500
TVTFDRNLTF ISVYNASHMV AYDKSIVARG ILDIYLDNVM LVEKETDSPD
510 520 530 540 550
VLISTNEPTF SDIEEEELDG EKEDEKDGVT EGDGEKSDTD EGKDTDKGKD
560 570 580 590 600
EKNDDDDDDD DDSDDDSDDD DDDDDDDDDD DDDDDDSDDD DDDDDDSDDN
610 620 630 640 650
EKDDKSESET KTHPKAKIAL LLLLFISVFG ITGSQALRQR NFQFRRAPLT
660 670 680 690 700
SNSFSSSSSP NDPSNWDSND DFDFDIENDP LPSTNNKHKA AKKKKDYVSI
710
PSDIDESFEL AEI
Length:713
Mass (Da):80,063
Last modified:October 2, 2007 - v1
Checksum:i3C8951CB2FB6041C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS480413 Genomic DNA. Translation: EDO16988.1.
RefSeqiXP_001644846.1. XM_001644796.1.

Genome annotation databases

GeneIDi5545175.
KEGGivpo:Kpol_1041p46.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS480413 Genomic DNA. Translation: EDO16988.1.
RefSeqiXP_001644846.1. XM_001644796.1.

3D structure databases

ProteinModelPortaliA7TLB3.
SMRiA7TLB3. Positions 24-505.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi436907.XP_001644846.1.

Protein family/group databases

MEROPSiS10.007.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5545175.
KEGGivpo:Kpol_1041p46.

Phylogenomic databases

eggNOGiCOG2939.
InParanoidiA7TLB3.
KOiK01288.
OrthoDBiEOG7TJ3SJ.
PhylomeDBiA7TLB3.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Independent sorting-out of thousands of duplicated gene pairs in two yeast species descended from a whole-genome duplication."
    Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.
    Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 22028 / DSM 70294.

Entry informationi

Entry nameiKEX1_VANPO
AccessioniPrimary (citable) accession number: A7TLB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: October 2, 2007
Last modified: June 24, 2015
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.