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A7TLB3 (KEX1_VANPO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pheromone-processing carboxypeptidase KEX1

EC=3.4.16.6
Alternative name(s):
Carboxypeptidase D
Gene names
Name:KEX1
ORF Names:Kpol_1041p46
OrganismVanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus) [Complete proteome]
Taxonomic identifier436907 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeVanderwaltozyma

Protein attributes

Sequence length713 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activity

Preferential release of a C-terminal arginine or lysine residue.

Subcellular location

Golgi apparatustrans-Golgi network membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentGolgi apparatus
Membrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

proteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 713691Pheromone-processing carboxypeptidase KEX1
PRO_0000411951

Regions

Topological domain23 – 616594Lumenal Potential
Transmembrane617 – 63721Helical; Potential
Topological domain638 – 71376Cytoplasmic Potential
Compositional bias554 – 59946Poly-Asp
Compositional bias651 – 6599Poly-Ser

Sites

Active site1961 By similarity
Active site4041 By similarity
Active site4681 By similarity

Amino acid modifications

Glycosylation4571N-linked (GlcNAc...) Potential
Glycosylation4651N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
A7TLB3 [UniParc].

Last modified October 2, 2007. Version 1.
Checksum: 3C8951CB2FB6041C

FASTA71380,063
        10         20         30         40         50         60 
MMVSYKLLSL ITLLFVAQCT TGLLKQDDYV VRPDLLPGIS SIKDKALIPK MYAGHIPLNL 

        70         80         90        100        110        120 
QKTTDENENT DESDSNSNTN YFFWKFQHQS VESPNLIFWL NGGPGCSSMD GALVETGPFR 

       130        140        150        160        170        180 
VDKNGKLYPN EGSWHSRGDL VYIDQPIGTG LSTSAAIPNL LDDLKEVSDN FILFLENYFT 

       190        200        210        220        230        240 
IFPNDLDKDI IIAGESYAGQ YIPFFAKAIK EYNQKISDNK KKINLRMLLI GNGWIDPITQ 

       250        260        270        280        290        300 
SLSYLPFAIE KNLVGKDTPD FETLLKAHEK CQNKINSISE DDNSFSHEEC ESIINMLVSV 

       310        320        330        340        350        360 
TKDNSPNVKS NEVCINIYDF NLRDSFPACG ANWPIDVSHV AKFFSTPGVI EALNLNAEEV 

       370        380        390        400        410        420 
PRWKECNYDV LNHLTNPVSK PSVRLLPELL ESGIEIILFN GENDLVCNNK GITDMISKLT 

       430        440        450        460        470        480 
WNGATGFSDK VQKYEWLFRD LTKDTEEPAG TVTFDRNLTF ISVYNASHMV AYDKSIVARG 

       490        500        510        520        530        540 
ILDIYLDNVM LVEKETDSPD VLISTNEPTF SDIEEEELDG EKEDEKDGVT EGDGEKSDTD 

       550        560        570        580        590        600 
EGKDTDKGKD EKNDDDDDDD DDSDDDSDDD DDDDDDDDDD DDDDDDSDDD DDDDDDSDDN 

       610        620        630        640        650        660 
EKDDKSESET KTHPKAKIAL LLLLFISVFG ITGSQALRQR NFQFRRAPLT SNSFSSSSSP 

       670        680        690        700        710 
NDPSNWDSND DFDFDIENDP LPSTNNKHKA AKKKKDYVSI PSDIDESFEL AEI 

« Hide

References

[1]"Independent sorting-out of thousands of duplicated gene pairs in two yeast species descended from a whole-genome duplication."
Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.
Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 22028 / DSM 70294.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS480413 Genomic DNA. Translation: EDO16988.1.
RefSeqXP_001644846.1. XM_001644796.1.

3D structure databases

ProteinModelPortalA7TLB3.
SMRA7TLB3. Positions 24-505.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING436907.A7TLB3.

Protein family/group databases

MEROPSS10.007.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5545175.
KEGGvpo:Kpol_1041p46.

Phylogenomic databases

eggNOGCOG2939.
KOK01288.
OrthoDBEOG7TJ3SJ.

Family and domain databases

InterProIPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
PROSITEPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKEX1_VANPO
AccessionPrimary (citable) accession number: A7TLB3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: October 2, 2007
Last modified: February 19, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries