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A7TLB3

- KEX1_VANPO

UniProt

A7TLB3 - KEX1_VANPO

Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 31 (01 Oct 2014)
      Sequence version 1 (02 Oct 2007)
      Previous versions | rss
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    Functioni

    Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.By similarity

    Catalytic activityi

    Preferential release of a C-terminal arginine or lysine residue.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei196 – 1961PROSITE-ProRule annotation
    Active sitei404 – 4041PROSITE-ProRule annotation
    Active sitei468 – 4681PROSITE-ProRule annotation

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Keywords - Biological processi

    Apoptosis

    Protein family/group databases

    MEROPSiS10.007.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
    Alternative name(s):
    Carboxypeptidase D
    Gene namesi
    Name:KEX1
    ORF Names:Kpol_1041p46
    OrganismiVanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)
    Taxonomic identifieri436907 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeVanderwaltozyma
    ProteomesiUP000000267: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 713691Pheromone-processing carboxypeptidase KEX1PRO_0000411951Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi457 – 4571N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi465 – 4651N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi436907.A7TLB3.

    Structurei

    3D structure databases

    ProteinModelPortaliA7TLB3.
    SMRiA7TLB3. Positions 24-505.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini23 – 616594LumenalSequence AnalysisAdd
    BLAST
    Topological domaini638 – 71376CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei617 – 63721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi554 – 59946Poly-AspAdd
    BLAST
    Compositional biasi651 – 6599Poly-Ser

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2939.
    KOiK01288.
    OrthoDBiEOG7TJ3SJ.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A7TLB3-1 [UniParc]FASTAAdd to Basket

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    MMVSYKLLSL ITLLFVAQCT TGLLKQDDYV VRPDLLPGIS SIKDKALIPK    50
    MYAGHIPLNL QKTTDENENT DESDSNSNTN YFFWKFQHQS VESPNLIFWL 100
    NGGPGCSSMD GALVETGPFR VDKNGKLYPN EGSWHSRGDL VYIDQPIGTG 150
    LSTSAAIPNL LDDLKEVSDN FILFLENYFT IFPNDLDKDI IIAGESYAGQ 200
    YIPFFAKAIK EYNQKISDNK KKINLRMLLI GNGWIDPITQ SLSYLPFAIE 250
    KNLVGKDTPD FETLLKAHEK CQNKINSISE DDNSFSHEEC ESIINMLVSV 300
    TKDNSPNVKS NEVCINIYDF NLRDSFPACG ANWPIDVSHV AKFFSTPGVI 350
    EALNLNAEEV PRWKECNYDV LNHLTNPVSK PSVRLLPELL ESGIEIILFN 400
    GENDLVCNNK GITDMISKLT WNGATGFSDK VQKYEWLFRD LTKDTEEPAG 450
    TVTFDRNLTF ISVYNASHMV AYDKSIVARG ILDIYLDNVM LVEKETDSPD 500
    VLISTNEPTF SDIEEEELDG EKEDEKDGVT EGDGEKSDTD EGKDTDKGKD 550
    EKNDDDDDDD DDSDDDSDDD DDDDDDDDDD DDDDDDSDDD DDDDDDSDDN 600
    EKDDKSESET KTHPKAKIAL LLLLFISVFG ITGSQALRQR NFQFRRAPLT 650
    SNSFSSSSSP NDPSNWDSND DFDFDIENDP LPSTNNKHKA AKKKKDYVSI 700
    PSDIDESFEL AEI 713
    Length:713
    Mass (Da):80,063
    Last modified:October 2, 2007 - v1
    Checksum:i3C8951CB2FB6041C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS480413 Genomic DNA. Translation: EDO16988.1.
    RefSeqiXP_001644846.1. XM_001644796.1.

    Genome annotation databases

    GeneIDi5545175.
    KEGGivpo:Kpol_1041p46.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS480413 Genomic DNA. Translation: EDO16988.1 .
    RefSeqi XP_001644846.1. XM_001644796.1.

    3D structure databases

    ProteinModelPortali A7TLB3.
    SMRi A7TLB3. Positions 24-505.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 436907.A7TLB3.

    Protein family/group databases

    MEROPSi S10.007.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5545175.
    KEGGi vpo:Kpol_1041p46.

    Phylogenomic databases

    eggNOGi COG2939.
    KOi K01288.
    OrthoDBi EOG7TJ3SJ.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Independent sorting-out of thousands of duplicated gene pairs in two yeast species descended from a whole-genome duplication."
      Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.
      Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 22028 / DSM 70294.

    Entry informationi

    Entry nameiKEX1_VANPO
    AccessioniPrimary (citable) accession number: A7TLB3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: October 2, 2007
    Last modified: October 1, 2014
    This is version 31 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3