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A7TJA0

- A7TJA0_VANPO

UniProt

A7TJA0 - A7TJA0_VANPO

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Protein

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene
Kpol_1004p44
Organism
Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei479 – 4791S-adenosyl-L-methionine By similarityUniRule annotation

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Alternative name(s):
Histone H3-K79 methyltransferase
Gene namesi
ORF Names:Kpol_1004p44Imported
OrganismiVanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)
Taxonomic identifieri436907 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeVanderwaltozyma
ProteomesiUP000000267: Unassembled WGS sequence

Subcellular locationi

Nucleus By similarity UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi436907.A7TJA0.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni429 – 4324S-adenosyl-L-methionine binding By similarityUniRule annotation
Regioni452 – 46110S-adenosyl-L-methionine binding By similarityUniRule annotation
Regioni516 – 5172S-adenosyl-L-methionine binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG294902.
KOiK11427.
OrthoDBiEOG7KH9VN.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR021162. Histone_H3-K79_MeTrfase_fungi.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF08123. DOT1. 1 hit.
[Graphical view]
PIRSFiPIRSF017570. Histone_H3-K79_MeTrfase. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51569. DOT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7TJA0-1 [UniParc]FASTAAdd to Basket

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MDSSVFSNNS GSVSVETSVE ISDSRVEGIH KVSKGSSGVQ SLLEDAYRYS    50
AHSDYTLPGG FLRQRKPPKR FVDSSDDEGD GPTDKKVVKI NQKKSMLSNG 100
VKSKSILNSG KSIDGLKKKP NGKDKKNGKV TSIEKTVKSN SKSKSESKLK 150
TNLKTKLKTK AELKSKSKSK STADSKPVSK LESNATSSKA KYTKKNKKSP 200
EPALLNNSVN GDSPNDSENT NNDNENKVIN DVPVTPSSFA DLTSPFFEFK 250
YKFFDIDYLK SNDRFKGNIT QSISITEKYY KSKGDNIIPK FVKLKYPLFL 300
NYEEEYHIDF SNESFSTIYN PMSEIGKIIE YCTEIYIPDQ FLKQLETEVI 350
KPLNETFDNS DELGFINTVN RYNDIIEKIP RDLMIEKLNN TKSIPKNFIH 400
DFLHIIYTRT IHPKANKLRQ YAAFSSFVYG ELLPSFLSEV YSECSLKEGD 450
VFMDLGSGVG NCVVQAALEY GCGLSFGCEI MENASDLTEA QFAELQQRAR 500
LFGIRLSPVE YSLRESFVDN KRVDELIKKC DVLLVNNFLF DSKLNLEVEK 550
IIQNCKSGCK IISLKSLRPL TYTIDFDDIE NILNRLSVKK HKLKENSVSW 600
THRGGEFYIS TVLSDVDDSL FTSNAGHRRN ERLKYTR 637
Length:637
Mass (Da):72,008
Last modified:October 2, 2007 - v1
Checksum:iCF048C6CC08E914E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS480400 Genomic DNA. Translation: EDO17669.1.
RefSeqiXP_001645527.1. XM_001645477.1.

Genome annotation databases

GeneIDi5545909.
KEGGivpo:Kpol_1004p44.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS480400 Genomic DNA. Translation: EDO17669.1 .
RefSeqi XP_001645527.1. XM_001645477.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 436907.A7TJA0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5545909.
KEGGi vpo:Kpol_1004p44.

Phylogenomic databases

eggNOGi NOG294902.
KOi K11427.
OrthoDBi EOG7KH9VN.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR021162. Histone_H3-K79_MeTrfase_fungi.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF08123. DOT1. 1 hit.
[Graphical view ]
PIRSFi PIRSF017570. Histone_H3-K79_MeTrfase. 1 hit.
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51569. DOT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Independent sorting-out of thousands of duplicated gene pairs in two yeast species descended from a whole-genome duplication."
    Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.
    Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 22028 / DSM 70294.

Entry informationi

Entry nameiA7TJA0_VANPO
AccessioniPrimary (citable) accession number: A7TJA0
Entry historyi
Integrated into UniProtKB/TrEMBL: October 2, 2007
Last sequence update: October 2, 2007
Last modified: June 11, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3