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A7TJA0

- A7TJA0_VANPO

UniProt

A7TJA0 - A7TJA0_VANPO

Protein

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene

Kpol_1004p44

Organism
Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (02 Oct 2007)
      Previous versions | rss
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    Functioni

    Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei479 – 4791S-adenosyl-L-methionineUniRule annotation

    GO - Molecular functioni

    1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulationUniRule annotation

    Keywords - Ligandi

    S-adenosyl-L-methionineUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
    Alternative name(s):
    Histone H3-K79 methyltransferaseUniRule annotation
    Gene namesi
    ORF Names:Kpol_1004p44Imported
    OrganismiVanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)Imported
    Taxonomic identifieri436907 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeVanderwaltozyma
    ProteomesiUP000000267: Unassembled WGS sequence

    Subcellular locationi

    Nucleus UniRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    NucleusUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi436907.A7TJA0.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni429 – 4324S-adenosyl-L-methionine bindingUniRule annotation
    Regioni452 – 46110S-adenosyl-L-methionine bindingUniRule annotation
    Regioni516 – 5172S-adenosyl-L-methionine bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.UniRule annotation

    Phylogenomic databases

    eggNOGiNOG294902.
    KOiK11427.
    OrthoDBiEOG7KH9VN.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR013110. DOT1.
    IPR025789. Histone_H3-K79_MeTrfase.
    IPR021162. Histone_H3-K79_MeTrfase_fungi.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF08123. DOT1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF017570. Histone_H3-K79_MeTrfase. 1 hit.
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51569. DOT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A7TJA0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSSVFSNNS GSVSVETSVE ISDSRVEGIH KVSKGSSGVQ SLLEDAYRYS    50
    AHSDYTLPGG FLRQRKPPKR FVDSSDDEGD GPTDKKVVKI NQKKSMLSNG 100
    VKSKSILNSG KSIDGLKKKP NGKDKKNGKV TSIEKTVKSN SKSKSESKLK 150
    TNLKTKLKTK AELKSKSKSK STADSKPVSK LESNATSSKA KYTKKNKKSP 200
    EPALLNNSVN GDSPNDSENT NNDNENKVIN DVPVTPSSFA DLTSPFFEFK 250
    YKFFDIDYLK SNDRFKGNIT QSISITEKYY KSKGDNIIPK FVKLKYPLFL 300
    NYEEEYHIDF SNESFSTIYN PMSEIGKIIE YCTEIYIPDQ FLKQLETEVI 350
    KPLNETFDNS DELGFINTVN RYNDIIEKIP RDLMIEKLNN TKSIPKNFIH 400
    DFLHIIYTRT IHPKANKLRQ YAAFSSFVYG ELLPSFLSEV YSECSLKEGD 450
    VFMDLGSGVG NCVVQAALEY GCGLSFGCEI MENASDLTEA QFAELQQRAR 500
    LFGIRLSPVE YSLRESFVDN KRVDELIKKC DVLLVNNFLF DSKLNLEVEK 550
    IIQNCKSGCK IISLKSLRPL TYTIDFDDIE NILNRLSVKK HKLKENSVSW 600
    THRGGEFYIS TVLSDVDDSL FTSNAGHRRN ERLKYTR 637
    Length:637
    Mass (Da):72,008
    Last modified:October 2, 2007 - v1
    Checksum:iCF048C6CC08E914E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS480400 Genomic DNA. Translation: EDO17669.1.
    RefSeqiXP_001645527.1. XM_001645477.1.

    Genome annotation databases

    GeneIDi5545909.
    KEGGivpo:Kpol_1004p44.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS480400 Genomic DNA. Translation: EDO17669.1 .
    RefSeqi XP_001645527.1. XM_001645477.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 436907.A7TJA0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5545909.
    KEGGi vpo:Kpol_1004p44.

    Phylogenomic databases

    eggNOGi NOG294902.
    KOi K11427.
    OrthoDBi EOG7KH9VN.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR013110. DOT1.
    IPR025789. Histone_H3-K79_MeTrfase.
    IPR021162. Histone_H3-K79_MeTrfase_fungi.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF08123. DOT1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF017570. Histone_H3-K79_MeTrfase. 1 hit.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51569. DOT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Independent sorting-out of thousands of duplicated gene pairs in two yeast species descended from a whole-genome duplication."
      Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.
      Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 22028 / DSM 70294Imported.

    Entry informationi

    Entry nameiA7TJA0_VANPO
    AccessioniPrimary (citable) accession number: A7TJA0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 2, 2007
    Last sequence update: October 2, 2007
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3