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A7TJA0 (A7TJA0_VANPO) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specific PIRNR PIRNR017570

EC=2.1.1.43 PIRNR PIRNR017570
Alternative name(s):
Histone H3-K79 methyltransferase PIRNR PIRNR017570
Gene names
ORF Names:Kpol_1004p44 EMBL EDO17669.1
OrganismVanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus) [Complete proteome]
Taxonomic identifier436907 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeVanderwaltozyma

Protein attributes

Sequence length637 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones By similarity. PIRNR PIRNR017570

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. PIRNR PIRNR017570

Subcellular location

Nucleus By similarity PIRNR PIRNR017570.

Sequence similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family. PIRNR PIRNR017570

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region429 – 4324S-adenosyl-L-methionine binding By similarity PIRSR PIRSR017570-1
Region452 – 46110S-adenosyl-L-methionine binding By similarity PIRSR PIRSR017570-1
Region516 – 5172S-adenosyl-L-methionine binding By similarity PIRSR PIRSR017570-1

Sites

Binding site4791S-adenosyl-L-methionine By similarity PIRSR PIRSR017570-1

Sequences

Sequence LengthMass (Da)Tools
A7TJA0 [UniParc].

Last modified October 2, 2007. Version 1.
Checksum: CF048C6CC08E914E

FASTA63772,008
        10         20         30         40         50         60 
MDSSVFSNNS GSVSVETSVE ISDSRVEGIH KVSKGSSGVQ SLLEDAYRYS AHSDYTLPGG 

        70         80         90        100        110        120 
FLRQRKPPKR FVDSSDDEGD GPTDKKVVKI NQKKSMLSNG VKSKSILNSG KSIDGLKKKP 

       130        140        150        160        170        180 
NGKDKKNGKV TSIEKTVKSN SKSKSESKLK TNLKTKLKTK AELKSKSKSK STADSKPVSK 

       190        200        210        220        230        240 
LESNATSSKA KYTKKNKKSP EPALLNNSVN GDSPNDSENT NNDNENKVIN DVPVTPSSFA 

       250        260        270        280        290        300 
DLTSPFFEFK YKFFDIDYLK SNDRFKGNIT QSISITEKYY KSKGDNIIPK FVKLKYPLFL 

       310        320        330        340        350        360 
NYEEEYHIDF SNESFSTIYN PMSEIGKIIE YCTEIYIPDQ FLKQLETEVI KPLNETFDNS 

       370        380        390        400        410        420 
DELGFINTVN RYNDIIEKIP RDLMIEKLNN TKSIPKNFIH DFLHIIYTRT IHPKANKLRQ 

       430        440        450        460        470        480 
YAAFSSFVYG ELLPSFLSEV YSECSLKEGD VFMDLGSGVG NCVVQAALEY GCGLSFGCEI 

       490        500        510        520        530        540 
MENASDLTEA QFAELQQRAR LFGIRLSPVE YSLRESFVDN KRVDELIKKC DVLLVNNFLF 

       550        560        570        580        590        600 
DSKLNLEVEK IIQNCKSGCK IISLKSLRPL TYTIDFDDIE NILNRLSVKK HKLKENSVSW 

       610        620        630 
THRGGEFYIS TVLSDVDDSL FTSNAGHRRN ERLKYTR 

« Hide

References

[1]"Independent sorting-out of thousands of duplicated gene pairs in two yeast species descended from a whole-genome duplication."
Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.
Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 22028 / DSM 70294.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS480400 Genomic DNA. Translation: EDO17669.1.
RefSeqXP_001645527.1. XM_001645477.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING436907.A7TJA0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5545909.
KEGGvpo:Kpol_1004p44.

Phylogenomic databases

eggNOGNOG294902.
KOK11427.
OrthoDBEOG7KH9VN.

Family and domain databases

Gene3D3.40.50.150. 1 hit.
InterProIPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR021162. Histone_H3-K79_MeTrfase_fungi.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamPF08123. DOT1. 1 hit.
[Graphical view]
PIRSFPIRSF017570. Histone_H3-K79_MeTrfase. 1 hit.
SUPFAMSSF53335. SSF53335. 1 hit.
PROSITEPS51569. DOT1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA7TJA0_VANPO
AccessionPrimary (citable) accession number: A7TJA0
Entry history
Integrated into UniProtKB/TrEMBL: October 2, 2007
Last sequence update: October 2, 2007
Last modified: June 11, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)