A7TJ85 (BNA7_VANPO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable kynurenine formamidase
EC=3.5.1.9

Alternative name(s):
Biosynthesis of nicotinic acid protein 7
Probable N-formylkynurenine formamidase

Gene names

Name:	BNA7
ORF Names:	Kpol_1004p28

Organism

Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus) [Complete proteome]

Taxonomic identifier

436907 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Vanderwaltozyma

Protein attributes

Sequence length	261 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the conversion of tryptophan to nicotinic acid, NAD(H) and NADP(H) By similarity.
Catalytic activity	N-formyl-L-kynurenine + H2O = formate + L-kynurenine.
Pathway	Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.
Sequence similarities	Belongs to the BNA7 family.

Ontologies

Keywords
Biological process	Tryptophan catabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	arylformamidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 261	261	Probable kynurenine formamidase		PRO_0000361885
Sites
	Active site	33	1	Potential
	Active site	112	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	A7TJ85 [UniParc]. Last modified October 2, 2007. Version 1. Checksum: 222B0368A9D94B99	FASTA	261	30,049
	10 20 30 40 50 60 MNDPTDTLYH QTAIHKLAEI GKNCKHLGII FIHGGAWVDP LNTSNDFKGI AGEISKVIEN 70 80 90 100 110 120 NNTQGFNISM FGIEYRLSPS VKHPIHITDV ITNTYKLINE YKIDILYIVG HSVGATLGLQ 130 140 150 160 170 180 LATDNRDYLI KYSSQLHLIR STIQGLFLLD GIYSLQELLK EYPTYDSFIS KAFTNYELEF 190 200 210 220 230 240 QDPKEYLDKE QQFIKNLSFY IIHSFQDELL TLRQTDYLVE LLKAKEISFN LSISDYGRHN 250 260 DVYINDRVAK LIIFNILSNI N

References

[1]

"Independent sorting-out of thousands of duplicated gene pairs in two yeast species descended from a whole-genome duplication." Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H. Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007) [PubMed: 17494770] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 22028 / DSM 70294.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DS480400 Genomic DNA. Translation: EDO17654.1.
RefSeq	XP_001645512.1. XM_001645462.1.
3D structure databases
ProteinModelPortal	A7TJ85.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5545893.
KEGG	vpo:Kpol_1004p28.
Phylogenomic databases
OrthoDB	EOG4GMZ6M.
PhylomeDB	A7TJ85.
Family and domain databases
InterPro	IPR013094. AB_hydrolase_3. [Graphical view]
KO	K14263.
Pfam	PF07859. Abhydrolase_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BNA7_VANPO

Accession

Primary (citable) accession number: A7TJ85

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	October 2, 2007
Last modified:	December 14, 2011
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program