ID   ATG1_VANPO              Reviewed;         994 AA.
AC   A7TIZ4;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   16-JUN-2009, entry version 14.
DE   RecName: Full=Serine/threonine-protein kinase atg1;
DE            EC=2.7.11.1;
DE   AltName: Full=Autophagy-related protein 1;
GN   Name=ATG1; ORFNames=Kpol_541p49;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294)
OS   (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
OC   Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M.,
RA   Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two
RT   yeast species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- FUNCTION: Serine/threonine protein kinase probably involved in the
CC       cytoplasm to vacuole transport (Cvt) and in autophagy, where it
CC       may be required for the formation of autophagosomes (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr
CC       protein kinase family. APG1/unc-51/ULK1 subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
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DR   EMBL; DS480398; EDO17806.1; -; Genomic_DNA.
DR   RefSeq; XP_001645664.1; -.
DR   GeneID; 5546060; -.
DR   KEGG; vpo:Kpol_541p49; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0006468; P:protein amino acid phosphorylation; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR000719; Prot_kinase_core.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR017442; Se/Thr_pkinase-rel.
DR   InterPro; IPR008271; Ser_thr_pkin_AS.
DR   InterPro; IPR002290; Ser_thr_pkinase.
DR   Pfam; PF00069; Pkinase; 1.
DR   ProDom; PD000001; Prot_kinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Autophagy; Complete proteome; Cytoplasm; Kinase;
KW   Nucleotide-binding; Protein transport;
KW   Serine/threonine-protein kinase; Transferase; Transport.
FT   CHAIN         1    994       Serine/threonine-protein kinase atg1.
FT                                /FTId=PRO_0000317799.
FT   DOMAIN        7    331       Protein kinase.
FT   NP_BIND      13     21       ATP (By similarity).
FT   COMPBIAS    377    525       Asn-rich.
FT   ACT_SITE    178    178       Proton acceptor (By similarity).
FT   BINDING      60     60       ATP (By similarity).
SQ   SEQUENCE   994 AA;  113085 MW;  9BD130D2C810CE81 CRC64;
     MIISGKYVIE KEIGKGSFAT VLKGYIIDDN DNNGNDTNNE DVEVNDDKRK YTTRNQIAVK
     AVPRSKLKNK KLLENLEVEI AILKKIKHPH IVRLIECERT STDFYLIMEY CALGDLTFLI
     KKRQEIMENH PLLKSVFKRF PPPSKNHNGL HRAFILNYLQ QLSSSLKFLR SKNLVHRDIK
     PQNLLLATPF VDYHDSKSFH DLGYVGISSL PILKIADFGF ARFLPNTSMA ETLCGSPLYM
     APEILNYQKY NAKADLWSVG TVLYEMCYGK PPFKASNHLE LYKKIKKANN TISYSNDCEI
     EDDLKDLINA LLTFDPNKRI GFQEFFDNKL VIEDLSKYEV ANEVYSELEL KSKSVLESNM
     FISEYLPSEK KKDDTDNMII SNLSTNDRIN NITIFSNILP TVNENENDKT NDNSTTNYNN
     NDNENNDNNN TNHNYNNDKV NNKSNDNNEK SDINRSNSNY KQHSTKQTTN ELIPNTNTIT
     TNINDNSNSE MNSQSARMMQ KSKNYKSLRN NKLRNSKNDI INNSNSDLIL EKEYVVVEKK
     SVEVNTLADE MAQIGQINNL NYKVPYPSRS PTLAGNVLQN NESLQHYQPF SVKSPRTSLS
     SNGSGNSRRA SLVDRRLSIS SLNPSNALSR ALGVASTKLF GSNVLPNQNA GVGNANNINT
     SMPLLNPQVF QDLTENILLR VDQLQGKDRI NIDSNSIVQI LESLAAKAFV VHSFAEVKFS
     QTIPLKSLST STVNRPANDR RLNDRGCAIE EDDNIQTETY DTYIPSLKGR SLSSLSQTSI
     CSQDLPHGEL YQLSKEAIIL YMKTLSILAT AMQITSNWWY QSNEKNCSLR LNLLVQWIRD
     KFNECLERAD FLRIQILELE ECENKSNELN SDHTDVETSG VNETVHNNDN DANEEDQIYV
     EKLLYDRALE ISRTAAKLEI QGDHLNNCEL AYATSLWMLE ILLDDRIEDD NFNEFSSKNS
     AVLDDQDREI IKKYIDSIAN RLKALREKIS QGGS
//