Reviewed,
UniProtKB/Swiss-Prot A7THG7 (LKHA4_VANPO)
Last modified
October 13, 2009.
Version 16.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Leukotriene A-4 hydrolase EC=3.3.2.6 Alternative name(s): Leukotriene A(4) hydrolase Short name=LTA-4 hydrolase | ||
| Gene names |
| ||
| Organism | Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus) [Complete proteome] | ||
| Taxonomic identifier | 436907 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Vanderwaltozyma |
Protein attributes
| Sequence length | 656 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Hydrolyzes an epoxide moiety of LTA4 to form LTB4. The enzyme also has some peptidase activity By similarity. |
| Catalytic activity | (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O = (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate. |
| Cofactor | Binds 1 zinc ion per subunit By similarity. |
| Pathway | |
| Subcellular location | |
| Sequence similarities | Belongs to the peptidase M1 family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Leukotriene biosynthesis |
| Cellular component | Cytoplasm Nucleus |
| Ligand | Metal-binding Zinc |
| Molecular function | Hydrolase Metalloprotease Protease |
| Technical term | Complete proteome Multifunctional enzyme |
| Gene Ontology (GO) | |
| Biological process | leukotriene biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW proteolysisInferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleusInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | leukotriene-A4 hydrolase activity Inferred from electronic annotation. Source: EC metallopeptidase activityInferred from electronic annotation. Source: UniProtKB-KW zinc ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 656 | 656 | Leukotriene A-4 hydrolase | PRO_0000324941 | |||||
Sites | |||||||||
| Active site | 332 | 1 | By similarity | ||||||
| Active site | 420 | 1 | Proton donor By similarity | ||||||
| Metal binding | 331 | 1 | Zinc; catalytic By similarity | ||||||
| Metal binding | 335 | 1 | Zinc; catalytic By similarity | ||||||
| Metal binding | 354 | 1 | Zinc; catalytic By similarity | ||||||
| Site | 235 | 1 | Transition state stabilizer By similarity | ||||||
Sequences
| ||||||||||||||||||
References
| [1] | "Independent sorting-out of thousands of duplicated gene pairs in two yeast species descended from a whole-genome duplication." Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H. Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007) [PubMed: 17494770] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| DS480391 Genomic DNA. Translation: EDO18291.1. | |
| RefSeq | XP_001646149.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 5546571. |
| KEGG | vpo:Kpol_1039p41. |
Family and domain databases | |
| InterPro | IPR012777. Leuk_A4_hydro_aminopept. IPR006025. Pept_M_Zn_BS. IPR001930. Peptidase_M1. IPR015211. Peptidase_M1_C. IPR014782. Peptidase_M1_N. [Graphical view] |
| PANTHER | PTHR11533. Peptidase_M1. 1 hit. |
| Pfam | PF09127. Leuk-A4-hydro_C. 1 hit. PF01433. Peptidase_M1. 1 hit. [Graphical view] |
| PRINTS | PR00756. ALADIPTASE. |
| TIGRFAMs | TIGR02411. leuko_A4_hydro. 1 hit. |
| PROSITE | PS00142. ZINC_PROTEASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | LKHA4_VANPO | ||||||||
| Accession | Primary (citable) accession number: A7THG7 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| Peptidase families Classification of peptidase families and list of entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with


