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A7TGW3

- A7TGW3_VANPO

UniProt

A7TGW3 - A7TGW3_VANPO

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Protein

DNA ligase

Gene

Kpol_1032p7

Organism
Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA biosynthetic process Source: InterPro
  2. DNA ligation involved in DNA repair Source: InterPro
  3. DNA recombination Source: UniProtKB-KW
  4. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:Kpol_1032p7Imported
OrganismiVanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)Imported
Taxonomic identifieri436907 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeVanderwaltozyma
ProteomesiUP000000267: Unassembled WGS sequence

Interactioni

Protein-protein interaction databases

STRINGi436907.A7TGW3.

Structurei

3D structure databases

ProteinModelPortaliA7TGW3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1793.
InParanoidiA7TGW3.
KOiK10777.
OrthoDBiEOG7QC84G.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
3.40.50.10190. 1 hit.
InterProiIPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR029710. LIG4.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PANTHERiPTHR10459:SF7. PTHR10459:SF7. 1 hit.
PfamiPF00533. BRCT. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 2 hits.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 2 hits.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50172. BRCT. 2 hits.
PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7TGW3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRNPTPILVS TNTNTNATFT SKADTNDIEE PHNFSPSPDF KWLCDELFVK
60 70 80 90 100
LDQIQFRPKE LNGSKPKYIE YYDIINNFID IWRRTVGNDI YPALILTIPY
110 120 130 140 150
RDRRMYNIKE SKLIRIVCDY LKLPKNSETE RRLMRWKHRA DRNVRLSTFC
160 170 180 190 200
VEEIKKRKGE PREKIKITID KLNECLDNLV LERGYKGSKS QKISESETFK
210 220 230 240 250
FCFENMTYVE LKYFFDILLK DKIVGGLEHK FLNCWHPDAQ DYLSVVSDLK
260 270 280 290 300
IVSSKLWNPE FRLKYDDLTI NIDHAFTPET AKRLTYSYDT IARRLKNDFF
310 320 330 340 350
IEEKMDGERI QLHYMNYGAK LKFLSRRGLD YSYLYGDNRN NGAIGRYLNF
360 370 380 390 400
HKDVKECILD GEMVTYDSVK NCILPFGLVK SSAMQSLSVS DIEPDGYHPL
410 420 430 440 450
YMAFDLVYLN GSSLSTLPLH QRKNYLDKLL IPCPDFVEIL PALHCNDSSL
460 470 480 490 500
IKSSLEKAIE LGSEGIILKR FDSQYLVAKR SDDWIKIKPE YLEQFGENMD
510 520 530 540 550
LIVIGRDPGK KDSLMCGLIL TGDNEPEEIT SLDSNPTDTA ESFLKPDKRK
560 570 580 590 600
IISFCNIANG ISQKEFRDID RYTFGHWIKF DDELPPQDLF EFGTKHPIEW
610 620 630 640 650
IYPEHSVVLE IKARSLETNE SARIKYGTGS TLFGGYCRQI RYDKDWVSCF
660 670 680 690 700
TYNEFMESRN LKNALVNYPD NKNLIGRKKR PKKRMFNSLT EIFENTKDAP
710 720 730 740 750
DESNVIFRGL HFYVISDYID ETDGSRLSKS DLCNLVLEHN GKLVHNPISR
760 770 780 790 800
IDILNRLRII SMKYTRETTS LIERGYDIIH PQWILDCISN RKLVRLLPSH
810 820 830 840 850
CFNVSSSLME VTKTRVDRYG DSYETSLTEK DFEILINRQV LKSESADKRI
860 870 880 890 900
TEGENHLKIP ILLFCNRRFF IPETLPSTPI YELKSKVELY GGKLVNKISD
910 920 930 940 950
CNVIVFTNTH TENRKEVMKK IRRALVCLDP NSMQVPVLPR IVDANWIDAC
960
ISECVQVPEE DYPAV
Length:965
Mass (Da):112,453
Last modified:October 2, 2007 - v1
Checksum:i18173392179317B9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS480389 Genomic DNA. Translation: EDO18415.1.
RefSeqiXP_001646273.1. XM_001646223.1.

Genome annotation databases

GeneIDi5546698.
KEGGivpo:Kpol_1032p7.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS480389 Genomic DNA. Translation: EDO18415.1 .
RefSeqi XP_001646273.1. XM_001646223.1.

3D structure databases

ProteinModelPortali A7TGW3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 436907.A7TGW3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5546698.
KEGGi vpo:Kpol_1032p7.

Phylogenomic databases

eggNOGi COG1793.
InParanoidi A7TGW3.
KOi K10777.
OrthoDBi EOG7QC84G.

Family and domain databases

Gene3Di 2.40.50.140. 1 hit.
3.40.50.10190. 1 hit.
InterProi IPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR029710. LIG4.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
PANTHERi PTHR10459:SF7. PTHR10459:SF7. 1 hit.
Pfami PF00533. BRCT. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SMARTi SM00292. BRCT. 2 hits.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 2 hits.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS50172. BRCT. 2 hits.
PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Independent sorting-out of thousands of duplicated gene pairs in two yeast species descended from a whole-genome duplication."
    Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.
    Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 22028 / DSM 70294Imported.

Entry informationi

Entry nameiA7TGW3_VANPO
AccessioniPrimary (citable) accession number: A7TGW3
Entry historyi
Integrated into UniProtKB/TrEMBL: October 2, 2007
Last sequence update: October 2, 2007
Last modified: October 29, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3