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Protein

Histone-lysine N-methyltransferase

Gene

Kpol_2001p35

Organism
Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferaseSAAS annotation (EC:2.1.1.43SAAS annotation)
Gene namesi
ORF Names:Kpol_2001p35Imported
OrganismiVanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)Imported
Taxonomic identifieri436907 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeVanderwaltozyma
ProteomesiUP000000267 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi436907.XP_001646388.1.

Structurei

3D structure databases

ProteinModelPortaliA7TGR7.
SMRiA7TGR7. Positions 458-484, 597-689.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation
Contains 1 post-SET domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG2940.
InParanoidiA7TGR7.
KOiK11423.
OrthoDBiEOG7P8PH3.
PhylomeDBiA7TGR7.

Family and domain databases

InterProiIPR006560. AWS_dom.
IPR025788. Hist-Lys_N-MeTrfase_SET2_fun.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR013257. SRI.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
PF08236. SRI. 1 hit.
[Graphical view]
SMARTiSM00570. AWS. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 1 hit.
PROSITEiPS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS51568. SAM_MT43_SET2_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7TGR7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSATSSPS LEASGSAVPA QRDFSNEEDK TQEALTTFIN LEDCKYASKY
60 70 80 90 100
IGNAKSSDFM ECDCYEEFEE GINHACDENS DCINRLTLIE CVNGLCDTCG
110 120 130 140 150
DNCQNQRFQK KEYADISVFK TKMKGYGVRA NKDIEANDFI YEYKGEVIEE
160 170 180 190 200
DEFRERLIDY DERGFKHFYF MMLQNAEFID ATIKGSLARF CNHSCNPNAY
210 220 230 240 250
VNKWVVAGKL KMGIFAKRDI YKGEEITFDY NVDRYGATAQ KCYCEEPNCI
260 270 280 290 300
GFLGGKTQTD SASLLPQSYA DALGVKVSVE KKWIREMKAK GLKIDKSNGT
310 320 330 340 350
NINISFVESL SLAACESMDE VTKVMSVLLQ IDDEYIGQKL LSRLFMITDE
360 370 380 390 400
SLLHQVIKFH GYRCFAKLLQ FYANDIGLLG QILEFLDRLP KTTKNGITSS
410 420 430 440 450
GIDKKINDLI TRDNTLYNKG EELLEKWNSY ETYNRISKKD INEISKKATD
460 470 480 490 500
VRRIRLPPGW EIVHENGQPM YYNAQLQTKL RHPPSGSSKT FNSRTSSRDN
510 520 530 540 550
LHGFHKKNSN FNKRHRLDDD AYEKIKMKRI ENEMKALEKA KDEEKRLLKE
560 570 580 590 600
KFELENQKKS ELTKIIEFAN KQKELEREQS IKEKEERAKR RVEKKQVSRS
610 620 630 640 650
SHIEHKWNKF FASVVPNLLK KYENEHNISH EHTKHCSREI VKILTSKELK
660 670 680 690
KDPSRAPDEE PTKEKRAKIR DFTTIYMDKF IQKYQDKKST KHA
Length:693
Mass (Da):80,340
Last modified:October 2, 2007 - v1
Checksum:iA3B8EF26D9FACE34
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS480388 Genomic DNA. Translation: EDO18530.1.
RefSeqiXP_001646388.1. XM_001646338.1.

Genome annotation databases

GeneIDi5546827.
KEGGivpo:Kpol_2001p35.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS480388 Genomic DNA. Translation: EDO18530.1.
RefSeqiXP_001646388.1. XM_001646338.1.

3D structure databases

ProteinModelPortaliA7TGR7.
SMRiA7TGR7. Positions 458-484, 597-689.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi436907.XP_001646388.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5546827.
KEGGivpo:Kpol_2001p35.

Phylogenomic databases

eggNOGiCOG2940.
InParanoidiA7TGR7.
KOiK11423.
OrthoDBiEOG7P8PH3.
PhylomeDBiA7TGR7.

Family and domain databases

InterProiIPR006560. AWS_dom.
IPR025788. Hist-Lys_N-MeTrfase_SET2_fun.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR013257. SRI.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
PF08236. SRI. 1 hit.
[Graphical view]
SMARTiSM00570. AWS. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 1 hit.
PROSITEiPS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS51568. SAM_MT43_SET2_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Independent sorting-out of thousands of duplicated gene pairs in two yeast species descended from a whole-genome duplication."
    Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.
    Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 22028 / DSM 70294Imported.

Entry informationi

Entry nameiA7TGR7_VANPO
AccessioniPrimary (citable) accession number: A7TGR7
Entry historyi
Integrated into UniProtKB/TrEMBL: October 2, 2007
Last sequence update: October 2, 2007
Last modified: July 22, 2015
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.