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Protein

Histone-lysine N-methyltransferase

Gene

Kpol_2001p35

Organism
Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].PROSITE-ProRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferasePROSITE-ProRule annotationSAAS annotation, Transferase
LigandS-adenosyl-L-methioninePROSITE-ProRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferasePROSITE-ProRule annotation (EC:2.1.1.43PROSITE-ProRule annotation)
Gene namesi
ORF Names:Kpol_2001p35Imported
OrganismiVanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)Imported
Taxonomic identifieri436907 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeVanderwaltozyma
Proteomesi
  • UP000000267 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi436907.XP_001646388.1

Structurei

3D structure databases

ProteinModelPortaliA7TGR7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 112AWSInterPro annotationAdd BLAST56
Domaini114 – 231SETInterPro annotationAdd BLAST118
Domaini238 – 254Post-SETInterPro annotationAdd BLAST17

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili527 – 557Sequence analysisAdd BLAST31
Coiled coili559 – 595Sequence analysisAdd BLAST37

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG4442 Eukaryota
COG2940 LUCA
InParanoidiA7TGR7
KOiK11423
OrthoDBiEOG092C3T9B
PhylomeDBiA7TGR7

Family and domain databases

Gene3Di1.10.1740.100, 1 hit
InterProiView protein in InterPro
IPR006560 AWS_dom
IPR025788 Hist-Lys_N-MeTrfase_SET2_fun
IPR003616 Post-SET_dom
IPR001214 SET_dom
IPR013257 SRI
IPR038190 SRI_sf
IPR036020 WW_dom_sf
PfamiView protein in Pfam
PF00856 SET, 1 hit
PF08236 SRI, 1 hit
SMARTiView protein in SMART
SM00570 AWS, 1 hit
SM00508 PostSET, 1 hit
SM00317 SET, 1 hit
SUPFAMiSSF51045 SSF51045, 1 hit
PROSITEiView protein in PROSITE
PS51215 AWS, 1 hit
PS50868 POST_SET, 1 hit
PS51568 SAM_MT43_SET2_1, 1 hit
PS50280 SET, 1 hit

Sequencei

Sequence statusi: Complete.

A7TGR7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSATSSPS LEASGSAVPA QRDFSNEEDK TQEALTTFIN LEDCKYASKY
60 70 80 90 100
IGNAKSSDFM ECDCYEEFEE GINHACDENS DCINRLTLIE CVNGLCDTCG
110 120 130 140 150
DNCQNQRFQK KEYADISVFK TKMKGYGVRA NKDIEANDFI YEYKGEVIEE
160 170 180 190 200
DEFRERLIDY DERGFKHFYF MMLQNAEFID ATIKGSLARF CNHSCNPNAY
210 220 230 240 250
VNKWVVAGKL KMGIFAKRDI YKGEEITFDY NVDRYGATAQ KCYCEEPNCI
260 270 280 290 300
GFLGGKTQTD SASLLPQSYA DALGVKVSVE KKWIREMKAK GLKIDKSNGT
310 320 330 340 350
NINISFVESL SLAACESMDE VTKVMSVLLQ IDDEYIGQKL LSRLFMITDE
360 370 380 390 400
SLLHQVIKFH GYRCFAKLLQ FYANDIGLLG QILEFLDRLP KTTKNGITSS
410 420 430 440 450
GIDKKINDLI TRDNTLYNKG EELLEKWNSY ETYNRISKKD INEISKKATD
460 470 480 490 500
VRRIRLPPGW EIVHENGQPM YYNAQLQTKL RHPPSGSSKT FNSRTSSRDN
510 520 530 540 550
LHGFHKKNSN FNKRHRLDDD AYEKIKMKRI ENEMKALEKA KDEEKRLLKE
560 570 580 590 600
KFELENQKKS ELTKIIEFAN KQKELEREQS IKEKEERAKR RVEKKQVSRS
610 620 630 640 650
SHIEHKWNKF FASVVPNLLK KYENEHNISH EHTKHCSREI VKILTSKELK
660 670 680 690
KDPSRAPDEE PTKEKRAKIR DFTTIYMDKF IQKYQDKKST KHA
Length:693
Mass (Da):80,340
Last modified:October 2, 2007 - v1
Checksum:iA3B8EF26D9FACE34
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS480388 Genomic DNA Translation: EDO18530.1
RefSeqiXP_001646388.1, XM_001646338.1

Genome annotation databases

EnsemblFungiiEDO18530; EDO18530; Kpol_2001p35
GeneIDi5546827
KEGGivpo:Kpol_2001p35

Similar proteinsi

Entry informationi

Entry nameiA7TGR7_VANPO
AccessioniPrimary (citable) accession number: A7TGR7
Entry historyiIntegrated into UniProtKB/TrEMBL: October 2, 2007
Last sequence update: October 2, 2007
Last modified: March 28, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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