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A7TGI1

- A7TGI1_VANPO

UniProt

A7TGI1 - A7TGI1_VANPO

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Protein

Histone-lysine N-methyltransferase, H3 lysine-4 specific

Gene
Kpol_1048p18
Organism
Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotationSAAS annotations

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotationSAAS annotations, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotationSAAS annotations

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-4 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Gene namesi
ORF Names:Kpol_1048p18Imported
OrganismiVanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)
Taxonomic identifieri436907 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeVanderwaltozyma
ProteomesiUP000000267: Unassembled WGS sequence

Subcellular locationi

Nucleus By similarity UniRule annotation

GO - Cellular componenti

  1. chromosome Source: UniProtKB-KW
  2. Set1C/COMPASS complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

ChromosomeUniRule annotation, NucleusUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Component of the COMPASS (Set1C) complex By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi436907.A7TGI1.

Structurei

3D structure databases

ProteinModelPortaliA7TGI1.
SMRiA7TGI1. Positions 251-363.

Family & Domainsi

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation
Contains SET domain.SAAS annotations
Contains post-SET domain.SAAS annotations

Phylogenomic databases

eggNOGiCOG2940.
KOiK11422.
OrthoDBiEOG7P8PH3.

Family and domain databases

InterProiIPR024657. COMPASS_Set1_N-SET.
IPR017111. Hist_H3-K4_MeTrfase_1_fun.
IPR003616. Post-SET_dom.
IPR024636. SET_assoc.
IPR001214. SET_dom.
[Graphical view]
PfamiPF11764. N-SET. 1 hit.
PF00856. SET. 1 hit.
PF11767. SET_assoc. 1 hit.
[Graphical view]
PIRSFiPIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMARTiSM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS50868. POST_SET. 1 hit.
PS51572. SAM_MT43_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7TGI1-1 [UniParc]FASTAAdd to Basket

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MSGSYRRPYQ SSGPSHRQYQ YNQQQRPYAN QYNGRRNNYD FYNDHRQGHY     50
GGHSYNSSYG GNGYPYRHGM SNSPMHSNNS SNSSNSNNNN NNNNNINNIH 100
NTDNGGAMDS NDYYNSIGDI RSYSGVSRNN ESKEFLKLVR PQPVIRYDTN 150
FYKSKYHYFD PVTKMLIHQQ EMSNWRNNEE MPTNGFVLVH ENHNGAIRSI 200
MRGIDYNGCS KDPRTSSNFT SNTSRSKVKN TLKTLPSIPY DKFSVGPPPP 250
TEIVIYPAST INMISELSVK NYFKEFGEIS HFEVFNDPNS ALSLNVYLVR 300
YNSPDGKLKN AIKAAKYAVQ KHEEKGCSIL GCHFNVVLNK DNVIKSIISK 350
FVQENLKKAK DINIDERNKN DKERKIVDIA PKNNFQDRRI PLDIKDIVNN 400
RPVLFVPKSF TSIHSFRVED FKLKLRKYRW ARILDHQAGI YIVFNDLVHA 450
RSCMNAESGI MTLISRSRNI PIEVRLKLLA PEPIPTPVSK PTKSIVGELK 500
FPTKPAAKVY SSKKDIVATA MKMITRDLEN ALSIDIRRKI IGPVVFDGLN 550
SSNYPELVKK KELNELEKLN KKKDLETKKT EAKEERSKFD LFDLYGGYVK 600
SNKKRRASDN LEKANRKRRG SIDNKPTAHM LNEDTISKES TPLEYSASLS 650
RFSGDEALLS EESSIESEDE VTESTKSEEE TIKEEETKFD EEKEAGIGKE 700
LNVEEKEGEE EEFSHAKVEN ELSNQIYAPI ASVYPEPVYS YELFELESES 750
AVISVEDLQS VVKDEEDMKY LRKVCETDSI PTVSAQIAAS FEYELWKLRR 800
FNKMKAKISE KHLELNEVPY DSSLDNGDKA FKAVGFKKVP DRIKSCYLPH 850
RRKLHQPLNT VNIHNDTLEK QRSNQADDMD KADSSEVSAE VSSSRVNRAI 900
NRRFQQDIEA QKAAIGTESE LLSLNQLNKR KKPVTFARSA IHNWGLYALE 950
PIAAKEMIIE YVGERIRQPV AEMRERRYIK NGIGSSYLFR VDENTVIDAT 1000
KRGGIARFIN HCCDPSCTAK IIKVGGMKRI VIYALRDIAS NEELTYDYKF 1050
EREMDDKERL PCLCGAATCK GFLN 1074
Length:1,074
Mass (Da):122,913
Last modified:October 2, 2007 - v1
Checksum:i5869A9997B385594
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS480387 Genomic DNA. Translation: EDO18588.1.
RefSeqiXP_001646446.1. XM_001646396.1.

Genome annotation databases

GeneIDi5546888.
KEGGivpo:Kpol_1048p18.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS480387 Genomic DNA. Translation: EDO18588.1 .
RefSeqi XP_001646446.1. XM_001646396.1.

3D structure databases

ProteinModelPortali A7TGI1.
SMRi A7TGI1. Positions 251-363.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 436907.A7TGI1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5546888.
KEGGi vpo:Kpol_1048p18.

Phylogenomic databases

eggNOGi COG2940.
KOi K11422.
OrthoDBi EOG7P8PH3.

Family and domain databases

InterProi IPR024657. COMPASS_Set1_N-SET.
IPR017111. Hist_H3-K4_MeTrfase_1_fun.
IPR003616. Post-SET_dom.
IPR024636. SET_assoc.
IPR001214. SET_dom.
[Graphical view ]
Pfami PF11764. N-SET. 1 hit.
PF00856. SET. 1 hit.
PF11767. SET_assoc. 1 hit.
[Graphical view ]
PIRSFi PIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMARTi SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view ]
PROSITEi PS50868. POST_SET. 1 hit.
PS51572. SAM_MT43_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Independent sorting-out of thousands of duplicated gene pairs in two yeast species descended from a whole-genome duplication."
    Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.
    Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 22028 / DSM 70294.

Entry informationi

Entry nameiA7TGI1_VANPO
AccessioniPrimary (citable) accession number: A7TGI1
Entry historyi
Integrated into UniProtKB/TrEMBL: October 2, 2007
Last sequence update: October 2, 2007
Last modified: May 14, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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