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Protein

Histone-lysine N-methyltransferase, H3 lysine-4 specific

Gene

Kpol_1048p18

Organism
Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotationSAAS annotation

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-4 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Gene namesi
ORF Names:Kpol_1048p18Imported
OrganismiVanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)Imported
Taxonomic identifieri436907 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeVanderwaltozyma
ProteomesiUP000000267 Componenti: Unassembled WGS sequence

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. chromosome Source: UniProtKB-KW
  2. Set1C/COMPASS complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

ChromosomeUniRule annotation, NucleusUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Component of the COMPASS (Set1C) complex.UniRule annotation

Protein-protein interaction databases

STRINGi436907.A7TGI1.

Structurei

3D structure databases

ProteinModelPortaliA7TGI1.
SMRiA7TGI1. Positions 251-363.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation
Contains 1 post-SET domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG2940.
InParanoidiA7TGI1.
KOiK11422.
OrthoDBiEOG7P8PH3.

Family and domain databases

InterProiIPR024657. COMPASS_Set1_N-SET.
IPR017111. Hist_H3-K4_MeTrfase_1_fun.
IPR003616. Post-SET_dom.
IPR024636. SET_assoc.
IPR001214. SET_dom.
[Graphical view]
PfamiPF11764. N-SET. 1 hit.
PF00856. SET. 1 hit.
PF11767. SET_assoc. 1 hit.
[Graphical view]
PIRSFiPIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMARTiSM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS50868. POST_SET. 1 hit.
PS51572. SAM_MT43_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7TGI1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGSYRRPYQ SSGPSHRQYQ YNQQQRPYAN QYNGRRNNYD FYNDHRQGHY
60 70 80 90 100
GGHSYNSSYG GNGYPYRHGM SNSPMHSNNS SNSSNSNNNN NNNNNINNIH
110 120 130 140 150
NTDNGGAMDS NDYYNSIGDI RSYSGVSRNN ESKEFLKLVR PQPVIRYDTN
160 170 180 190 200
FYKSKYHYFD PVTKMLIHQQ EMSNWRNNEE MPTNGFVLVH ENHNGAIRSI
210 220 230 240 250
MRGIDYNGCS KDPRTSSNFT SNTSRSKVKN TLKTLPSIPY DKFSVGPPPP
260 270 280 290 300
TEIVIYPAST INMISELSVK NYFKEFGEIS HFEVFNDPNS ALSLNVYLVR
310 320 330 340 350
YNSPDGKLKN AIKAAKYAVQ KHEEKGCSIL GCHFNVVLNK DNVIKSIISK
360 370 380 390 400
FVQENLKKAK DINIDERNKN DKERKIVDIA PKNNFQDRRI PLDIKDIVNN
410 420 430 440 450
RPVLFVPKSF TSIHSFRVED FKLKLRKYRW ARILDHQAGI YIVFNDLVHA
460 470 480 490 500
RSCMNAESGI MTLISRSRNI PIEVRLKLLA PEPIPTPVSK PTKSIVGELK
510 520 530 540 550
FPTKPAAKVY SSKKDIVATA MKMITRDLEN ALSIDIRRKI IGPVVFDGLN
560 570 580 590 600
SSNYPELVKK KELNELEKLN KKKDLETKKT EAKEERSKFD LFDLYGGYVK
610 620 630 640 650
SNKKRRASDN LEKANRKRRG SIDNKPTAHM LNEDTISKES TPLEYSASLS
660 670 680 690 700
RFSGDEALLS EESSIESEDE VTESTKSEEE TIKEEETKFD EEKEAGIGKE
710 720 730 740 750
LNVEEKEGEE EEFSHAKVEN ELSNQIYAPI ASVYPEPVYS YELFELESES
760 770 780 790 800
AVISVEDLQS VVKDEEDMKY LRKVCETDSI PTVSAQIAAS FEYELWKLRR
810 820 830 840 850
FNKMKAKISE KHLELNEVPY DSSLDNGDKA FKAVGFKKVP DRIKSCYLPH
860 870 880 890 900
RRKLHQPLNT VNIHNDTLEK QRSNQADDMD KADSSEVSAE VSSSRVNRAI
910 920 930 940 950
NRRFQQDIEA QKAAIGTESE LLSLNQLNKR KKPVTFARSA IHNWGLYALE
960 970 980 990 1000
PIAAKEMIIE YVGERIRQPV AEMRERRYIK NGIGSSYLFR VDENTVIDAT
1010 1020 1030 1040 1050
KRGGIARFIN HCCDPSCTAK IIKVGGMKRI VIYALRDIAS NEELTYDYKF
1060 1070
EREMDDKERL PCLCGAATCK GFLN
Length:1,074
Mass (Da):122,913
Last modified:October 2, 2007 - v1
Checksum:i5869A9997B385594
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS480387 Genomic DNA. Translation: EDO18588.1.
RefSeqiXP_001646446.1. XM_001646396.1.

Genome annotation databases

GeneIDi5546888.
KEGGivpo:Kpol_1048p18.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS480387 Genomic DNA. Translation: EDO18588.1.
RefSeqiXP_001646446.1. XM_001646396.1.

3D structure databases

ProteinModelPortaliA7TGI1.
SMRiA7TGI1. Positions 251-363.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi436907.A7TGI1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5546888.
KEGGivpo:Kpol_1048p18.

Phylogenomic databases

eggNOGiCOG2940.
InParanoidiA7TGI1.
KOiK11422.
OrthoDBiEOG7P8PH3.

Family and domain databases

InterProiIPR024657. COMPASS_Set1_N-SET.
IPR017111. Hist_H3-K4_MeTrfase_1_fun.
IPR003616. Post-SET_dom.
IPR024636. SET_assoc.
IPR001214. SET_dom.
[Graphical view]
PfamiPF11764. N-SET. 1 hit.
PF00856. SET. 1 hit.
PF11767. SET_assoc. 1 hit.
[Graphical view]
PIRSFiPIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMARTiSM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS50868. POST_SET. 1 hit.
PS51572. SAM_MT43_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Independent sorting-out of thousands of duplicated gene pairs in two yeast species descended from a whole-genome duplication."
    Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.
    Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 22028 / DSM 70294Imported.

Entry informationi

Entry nameiA7TGI1_VANPO
AccessioniPrimary (citable) accession number: A7TGI1
Entry historyi
Integrated into UniProtKB/TrEMBL: October 2, 2007
Last sequence update: October 2, 2007
Last modified: April 1, 2015
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.