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A7TGI1

- A7TGI1_VANPO

UniProt

A7TGI1 - A7TGI1_VANPO

Protein

Histone-lysine N-methyltransferase, H3 lysine-4 specific

Gene

Kpol_1048p18

Organism
Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (02 Oct 2007)
      Previous versions | rss
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    Functioni

    Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotationSAAS annotation

    GO - Molecular functioni

    1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotationSAAS annotation, Transferase

    Keywords - Ligandi

    S-adenosyl-L-methionineUniRule annotationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase, H3 lysine-4 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
    Gene namesi
    ORF Names:Kpol_1048p18Imported
    OrganismiVanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)Imported
    Taxonomic identifieri436907 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeVanderwaltozyma
    ProteomesiUP000000267: Unassembled WGS sequence

    Subcellular locationi

    Nucleus UniRule annotation

    GO - Cellular componenti

    1. chromosome Source: UniProtKB-KW
    2. Set1C/COMPASS complex Source: InterPro

    Keywords - Cellular componenti

    ChromosomeUniRule annotation, NucleusUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Component of the COMPASS (Set1C) complex.UniRule annotation

    Protein-protein interaction databases

    STRINGi436907.A7TGI1.

    Structurei

    3D structure databases

    ProteinModelPortaliA7TGI1.
    SMRiA7TGI1. Positions 251-363.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 SET domain.UniRule annotation
    Contains SET domain.SAAS annotation
    Contains post-SET domain.SAAS annotation

    Phylogenomic databases

    eggNOGiCOG2940.
    KOiK11422.
    OrthoDBiEOG7P8PH3.

    Family and domain databases

    InterProiIPR024657. COMPASS_Set1_N-SET.
    IPR017111. Hist_H3-K4_MeTrfase_1_fun.
    IPR003616. Post-SET_dom.
    IPR024636. SET_assoc.
    IPR001214. SET_dom.
    [Graphical view]
    PfamiPF11764. N-SET. 1 hit.
    PF00856. SET. 1 hit.
    PF11767. SET_assoc. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
    SMARTiSM00508. PostSET. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view]
    PROSITEiPS50868. POST_SET. 1 hit.
    PS51572. SAM_MT43_1. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A7TGI1-1 [UniParc]FASTAAdd to Basket

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    MSGSYRRPYQ SSGPSHRQYQ YNQQQRPYAN QYNGRRNNYD FYNDHRQGHY     50
    GGHSYNSSYG GNGYPYRHGM SNSPMHSNNS SNSSNSNNNN NNNNNINNIH 100
    NTDNGGAMDS NDYYNSIGDI RSYSGVSRNN ESKEFLKLVR PQPVIRYDTN 150
    FYKSKYHYFD PVTKMLIHQQ EMSNWRNNEE MPTNGFVLVH ENHNGAIRSI 200
    MRGIDYNGCS KDPRTSSNFT SNTSRSKVKN TLKTLPSIPY DKFSVGPPPP 250
    TEIVIYPAST INMISELSVK NYFKEFGEIS HFEVFNDPNS ALSLNVYLVR 300
    YNSPDGKLKN AIKAAKYAVQ KHEEKGCSIL GCHFNVVLNK DNVIKSIISK 350
    FVQENLKKAK DINIDERNKN DKERKIVDIA PKNNFQDRRI PLDIKDIVNN 400
    RPVLFVPKSF TSIHSFRVED FKLKLRKYRW ARILDHQAGI YIVFNDLVHA 450
    RSCMNAESGI MTLISRSRNI PIEVRLKLLA PEPIPTPVSK PTKSIVGELK 500
    FPTKPAAKVY SSKKDIVATA MKMITRDLEN ALSIDIRRKI IGPVVFDGLN 550
    SSNYPELVKK KELNELEKLN KKKDLETKKT EAKEERSKFD LFDLYGGYVK 600
    SNKKRRASDN LEKANRKRRG SIDNKPTAHM LNEDTISKES TPLEYSASLS 650
    RFSGDEALLS EESSIESEDE VTESTKSEEE TIKEEETKFD EEKEAGIGKE 700
    LNVEEKEGEE EEFSHAKVEN ELSNQIYAPI ASVYPEPVYS YELFELESES 750
    AVISVEDLQS VVKDEEDMKY LRKVCETDSI PTVSAQIAAS FEYELWKLRR 800
    FNKMKAKISE KHLELNEVPY DSSLDNGDKA FKAVGFKKVP DRIKSCYLPH 850
    RRKLHQPLNT VNIHNDTLEK QRSNQADDMD KADSSEVSAE VSSSRVNRAI 900
    NRRFQQDIEA QKAAIGTESE LLSLNQLNKR KKPVTFARSA IHNWGLYALE 950
    PIAAKEMIIE YVGERIRQPV AEMRERRYIK NGIGSSYLFR VDENTVIDAT 1000
    KRGGIARFIN HCCDPSCTAK IIKVGGMKRI VIYALRDIAS NEELTYDYKF 1050
    EREMDDKERL PCLCGAATCK GFLN 1074
    Length:1,074
    Mass (Da):122,913
    Last modified:October 2, 2007 - v1
    Checksum:i5869A9997B385594
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS480387 Genomic DNA. Translation: EDO18588.1.
    RefSeqiXP_001646446.1. XM_001646396.1.

    Genome annotation databases

    GeneIDi5546888.
    KEGGivpo:Kpol_1048p18.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS480387 Genomic DNA. Translation: EDO18588.1 .
    RefSeqi XP_001646446.1. XM_001646396.1.

    3D structure databases

    ProteinModelPortali A7TGI1.
    SMRi A7TGI1. Positions 251-363.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 436907.A7TGI1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5546888.
    KEGGi vpo:Kpol_1048p18.

    Phylogenomic databases

    eggNOGi COG2940.
    KOi K11422.
    OrthoDBi EOG7P8PH3.

    Family and domain databases

    InterProi IPR024657. COMPASS_Set1_N-SET.
    IPR017111. Hist_H3-K4_MeTrfase_1_fun.
    IPR003616. Post-SET_dom.
    IPR024636. SET_assoc.
    IPR001214. SET_dom.
    [Graphical view ]
    Pfami PF11764. N-SET. 1 hit.
    PF00856. SET. 1 hit.
    PF11767. SET_assoc. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
    SMARTi SM00508. PostSET. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view ]
    PROSITEi PS50868. POST_SET. 1 hit.
    PS51572. SAM_MT43_1. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Independent sorting-out of thousands of duplicated gene pairs in two yeast species descended from a whole-genome duplication."
      Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.
      Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 22028 / DSM 70294Imported.

    Entry informationi

    Entry nameiA7TGI1_VANPO
    AccessioniPrimary (citable) accession number: A7TGI1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 2, 2007
    Last sequence update: October 2, 2007
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3