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A7TGF1 (A7TGF1_VANPO) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length427 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. PIRNR PIRNR000108 RuleBase RU004443

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding86 – 883NADP By similarity PIRSR PIRSR000108-4
Nucleotide binding321 – 3266NADP By similarity PIRSR PIRSR000108-4
Region105 – 1117Substrate binding By similarity PIRSR PIRSR000108-2

Sites

Metal binding2631Magnesium or manganese By similarity
Metal binding2861Magnesium or manganese By similarity
Binding site881Substrate By similarity PIRSR PIRSR000108-2
Binding site931NADP By similarity PIRSR PIRSR000108-4
Binding site1201Substrate By similarity PIRSR PIRSR000108-2
Binding site1431Substrate By similarity PIRSR PIRSR000108-2
Binding site2711NADP By similarity PIRSR PIRSR000108-4
Binding site3391NADP; via amide nitrogen and carbonyl oxygen By similarity PIRSR PIRSR000108-4
Site1501Critical for catalysis By similarity PIRSR PIRSR000108-1
Site2231Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
A7TGF1 [UniParc].

Last modified October 2, 2007. Version 1.
Checksum: ECF719C5D2C33269

FASTA42747,765
        10         20         30         40         50         60 
MSRAYSSAAR KLSKITVKSP LVELDGDEMT RIIWSKIKKN LILPFLDVDL KYYDLSIENR 

        70         80         90        100        110        120 
DSTNDQVTVD AANAIKNFGV GVKCATITPD EARVEEFNLK KMWKSPNGTI RNILGGTVFR 

       130        140        150        160        170        180 
EPIVIPRIPR LIPGWEKPII IGRHAHGDQY KATDTLIPTA GKLELVFTPT DPNGERQILN 

       190        200        210        220        230        240 
VYDYKNSGVA LAMYNTDESI RGFAHSSFKL AINKKLNLFL STKNTILKKY DGRFKDIFQE 

       250        260        270        280        290        300 
IYESDYKSQF ENLGISYEHR LIDDMVAQMI KSKGGFIMAL KNYDGDVQSD IVAQGFGSLG 

       310        320        330        340        350        360 
LMTSVLVTPD GKTFESEAAH GTVTRHYRQY EQGKETSTNS IASIFAWSRG LAKRGELDST 

       370        380        390        400        410        420 
PDVIKFANLL ESATLNTVQQ DGIMTKDLAL ACGKTERSAY VTTDEFLDAV ATRLNNEFKS 


FENSSKL 

« Hide

References

[1]"Independent sorting-out of thousands of duplicated gene pairs in two yeast species descended from a whole-genome duplication."
Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.
Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 22028 / DSM 70294.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS480386 Genomic DNA. Translation: EDO18721.1.
RefSeqXP_001646579.1. XM_001646529.1.

3D structure databases

ProteinModelPortalA7TGF1.
SMRA7TGF1. Positions 14-415.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING436907.A7TGF1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5547031.
KEGGvpo:Kpol_1055p78.

Phylogenomic databases

eggNOGCOG0538.
KOK00031.
OrthoDBEOG7G4QQD.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA7TGF1_VANPO
AccessionPrimary (citable) accession number: A7TGF1
Entry history
Integrated into UniProtKB/TrEMBL: October 2, 2007
Last sequence update: October 2, 2007
Last modified: July 9, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)