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A7TGF1

- A7TGF1_VANPO

UniProt

A7TGF1 - A7TGF1_VANPO

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Protein
Isocitrate dehydrogenase [NADP]
Gene
Kpol_1055p78
Organism
Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei88 – 881Substrate By similarityUniRule annotation
Binding sitei93 – 931NADP By similarityUniRule annotation
Binding sitei120 – 1201Substrate By similarityUniRule annotation
Binding sitei143 – 1431Substrate By similarityUniRule annotation
Sitei150 – 1501Critical for catalysis By similarityUniRule annotation
Sitei223 – 2231Critical for catalysis By similarityUniRule annotation
Metal bindingi263 – 2631Magnesium or manganese By similarity
Binding sitei271 – 2711NADP By similarityUniRule annotation
Metal bindingi286 – 2861Magnesium or manganese By similarity
Binding sitei339 – 3391NADP; via amide nitrogen and carbonyl oxygen By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi86 – 883NADP By similarityUniRule annotation
Nucleotide bindingi321 – 3266NADP By similarityUniRule annotation

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
ORF Names:Kpol_1055p78Imported
OrganismiVanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)
Taxonomic identifieri436907 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeVanderwaltozyma
ProteomesiUP000000267: Unassembled WGS sequence

Interactioni

Protein-protein interaction databases

STRINGi436907.A7TGF1.

Structurei

3D structure databases

ProteinModelPortaliA7TGF1.
SMRiA7TGF1. Positions 14-415.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni105 – 1117Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0538.
KOiK00031.
OrthoDBiEOG7G4QQD.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7TGF1-1 [UniParc]FASTAAdd to Basket

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MSRAYSSAAR KLSKITVKSP LVELDGDEMT RIIWSKIKKN LILPFLDVDL    50
KYYDLSIENR DSTNDQVTVD AANAIKNFGV GVKCATITPD EARVEEFNLK 100
KMWKSPNGTI RNILGGTVFR EPIVIPRIPR LIPGWEKPII IGRHAHGDQY 150
KATDTLIPTA GKLELVFTPT DPNGERQILN VYDYKNSGVA LAMYNTDESI 200
RGFAHSSFKL AINKKLNLFL STKNTILKKY DGRFKDIFQE IYESDYKSQF 250
ENLGISYEHR LIDDMVAQMI KSKGGFIMAL KNYDGDVQSD IVAQGFGSLG 300
LMTSVLVTPD GKTFESEAAH GTVTRHYRQY EQGKETSTNS IASIFAWSRG 350
LAKRGELDST PDVIKFANLL ESATLNTVQQ DGIMTKDLAL ACGKTERSAY 400
VTTDEFLDAV ATRLNNEFKS FENSSKL 427
Length:427
Mass (Da):47,765
Last modified:October 2, 2007 - v1
Checksum:iECF719C5D2C33269
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS480386 Genomic DNA. Translation: EDO18721.1.
RefSeqiXP_001646579.1. XM_001646529.1.

Genome annotation databases

GeneIDi5547031.
KEGGivpo:Kpol_1055p78.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS480386 Genomic DNA. Translation: EDO18721.1 .
RefSeqi XP_001646579.1. XM_001646529.1.

3D structure databases

ProteinModelPortali A7TGF1.
SMRi A7TGF1. Positions 14-415.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 436907.A7TGF1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5547031.
KEGGi vpo:Kpol_1055p78.

Phylogenomic databases

eggNOGi COG0538.
KOi K00031.
OrthoDBi EOG7G4QQD.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Independent sorting-out of thousands of duplicated gene pairs in two yeast species descended from a whole-genome duplication."
    Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.
    Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 22028 / DSM 70294.

Entry informationi

Entry nameiA7TGF1_VANPO
AccessioniPrimary (citable) accession number: A7TGF1
Entry historyi
Integrated into UniProtKB/TrEMBL: October 2, 2007
Last sequence update: October 2, 2007
Last modified: July 9, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3