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Protein

Isocitrate dehydrogenase [NADP]

Gene

Kpol_1055p78

Organism
Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei88 – 881SubstrateUniRule annotation
Binding sitei93 – 931NADPUniRule annotation
Binding sitei120 – 1201SubstrateUniRule annotation
Binding sitei143 – 1431SubstrateUniRule annotation
Sitei150 – 1501Critical for catalysisUniRule annotation
Sitei223 – 2231Critical for catalysisUniRule annotation
Metal bindingi263 – 2631Magnesium or manganeseUniRule annotation
Binding sitei271 – 2711NADPUniRule annotation
Metal bindingi286 – 2861Magnesium or manganeseUniRule annotation
Binding sitei339 – 3391NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi86 – 883NADPUniRule annotation
Nucleotide bindingi321 – 3266NADPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
ORF Names:Kpol_1055p78Imported
OrganismiVanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)Imported
Taxonomic identifieri436907 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeVanderwaltozyma
ProteomesiUP000000267 Componenti: Unassembled WGS sequence

Interactioni

Protein-protein interaction databases

STRINGi436907.XP_001646579.1.

Structurei

3D structure databases

ProteinModelPortaliA7TGF1.
SMRiA7TGF1. Positions 14-415.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni105 – 1117Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0538.
InParanoidiA7TGF1.
KOiK00031.
OrthoDBiEOG7G4QQD.
PhylomeDBiA7TGF1.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7TGF1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRAYSSAAR KLSKITVKSP LVELDGDEMT RIIWSKIKKN LILPFLDVDL
60 70 80 90 100
KYYDLSIENR DSTNDQVTVD AANAIKNFGV GVKCATITPD EARVEEFNLK
110 120 130 140 150
KMWKSPNGTI RNILGGTVFR EPIVIPRIPR LIPGWEKPII IGRHAHGDQY
160 170 180 190 200
KATDTLIPTA GKLELVFTPT DPNGERQILN VYDYKNSGVA LAMYNTDESI
210 220 230 240 250
RGFAHSSFKL AINKKLNLFL STKNTILKKY DGRFKDIFQE IYESDYKSQF
260 270 280 290 300
ENLGISYEHR LIDDMVAQMI KSKGGFIMAL KNYDGDVQSD IVAQGFGSLG
310 320 330 340 350
LMTSVLVTPD GKTFESEAAH GTVTRHYRQY EQGKETSTNS IASIFAWSRG
360 370 380 390 400
LAKRGELDST PDVIKFANLL ESATLNTVQQ DGIMTKDLAL ACGKTERSAY
410 420
VTTDEFLDAV ATRLNNEFKS FENSSKL
Length:427
Mass (Da):47,765
Last modified:October 2, 2007 - v1
Checksum:iECF719C5D2C33269
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS480386 Genomic DNA. Translation: EDO18721.1.
RefSeqiXP_001646579.1. XM_001646529.1.

Genome annotation databases

GeneIDi5547031.
KEGGivpo:Kpol_1055p78.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS480386 Genomic DNA. Translation: EDO18721.1.
RefSeqiXP_001646579.1. XM_001646529.1.

3D structure databases

ProteinModelPortaliA7TGF1.
SMRiA7TGF1. Positions 14-415.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi436907.XP_001646579.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5547031.
KEGGivpo:Kpol_1055p78.

Phylogenomic databases

eggNOGiCOG0538.
InParanoidiA7TGF1.
KOiK00031.
OrthoDBiEOG7G4QQD.
PhylomeDBiA7TGF1.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Independent sorting-out of thousands of duplicated gene pairs in two yeast species descended from a whole-genome duplication."
    Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.
    Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 22028 / DSM 70294Imported.

Entry informationi

Entry nameiA7TGF1_VANPO
AccessioniPrimary (citable) accession number: A7TGF1
Entry historyi
Integrated into UniProtKB/TrEMBL: October 2, 2007
Last sequence update: October 2, 2007
Last modified: June 24, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.