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A7TGF1

- A7TGF1_VANPO

UniProt

A7TGF1 - A7TGF1_VANPO

Protein

Isocitrate dehydrogenase [NADP]

Gene

Kpol_1055p78

Organism
Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (02 Oct 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei88 – 881SubstrateUniRule annotation
    Binding sitei93 – 931NADPUniRule annotation
    Binding sitei120 – 1201SubstrateUniRule annotation
    Binding sitei143 – 1431SubstrateUniRule annotation
    Sitei150 – 1501Critical for catalysisUniRule annotation
    Sitei223 – 2231Critical for catalysisUniRule annotation
    Metal bindingi263 – 2631Magnesium or manganeseUniRule annotation
    Binding sitei271 – 2711NADPUniRule annotation
    Metal bindingi286 – 2861Magnesium or manganeseUniRule annotation
    Binding sitei339 – 3391NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi86 – 883NADPUniRule annotation
    Nucleotide bindingi321 – 3266NADPUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. isocitrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    ORF Names:Kpol_1055p78Imported
    OrganismiVanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)Imported
    Taxonomic identifieri436907 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeVanderwaltozyma
    ProteomesiUP000000267: Unassembled WGS sequence

    Interactioni

    Protein-protein interaction databases

    STRINGi436907.A7TGF1.

    Structurei

    3D structure databases

    ProteinModelPortaliA7TGF1.
    SMRiA7TGF1. Positions 14-415.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni105 – 1117Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0538.
    KOiK00031.
    OrthoDBiEOG7G4QQD.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11822. PTHR11822. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A7TGF1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRAYSSAAR KLSKITVKSP LVELDGDEMT RIIWSKIKKN LILPFLDVDL    50
    KYYDLSIENR DSTNDQVTVD AANAIKNFGV GVKCATITPD EARVEEFNLK 100
    KMWKSPNGTI RNILGGTVFR EPIVIPRIPR LIPGWEKPII IGRHAHGDQY 150
    KATDTLIPTA GKLELVFTPT DPNGERQILN VYDYKNSGVA LAMYNTDESI 200
    RGFAHSSFKL AINKKLNLFL STKNTILKKY DGRFKDIFQE IYESDYKSQF 250
    ENLGISYEHR LIDDMVAQMI KSKGGFIMAL KNYDGDVQSD IVAQGFGSLG 300
    LMTSVLVTPD GKTFESEAAH GTVTRHYRQY EQGKETSTNS IASIFAWSRG 350
    LAKRGELDST PDVIKFANLL ESATLNTVQQ DGIMTKDLAL ACGKTERSAY 400
    VTTDEFLDAV ATRLNNEFKS FENSSKL 427
    Length:427
    Mass (Da):47,765
    Last modified:October 2, 2007 - v1
    Checksum:iECF719C5D2C33269
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS480386 Genomic DNA. Translation: EDO18721.1.
    RefSeqiXP_001646579.1. XM_001646529.1.

    Genome annotation databases

    GeneIDi5547031.
    KEGGivpo:Kpol_1055p78.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS480386 Genomic DNA. Translation: EDO18721.1 .
    RefSeqi XP_001646579.1. XM_001646529.1.

    3D structure databases

    ProteinModelPortali A7TGF1.
    SMRi A7TGF1. Positions 14-415.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 436907.A7TGF1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5547031.
    KEGGi vpo:Kpol_1055p78.

    Phylogenomic databases

    eggNOGi COG0538.
    KOi K00031.
    OrthoDBi EOG7G4QQD.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11822. PTHR11822. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Independent sorting-out of thousands of duplicated gene pairs in two yeast species descended from a whole-genome duplication."
      Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.
      Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 22028 / DSM 70294Imported.

    Entry informationi

    Entry nameiA7TGF1_VANPO
    AccessioniPrimary (citable) accession number: A7TGF1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 2, 2007
    Last sequence update: October 2, 2007
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3