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A7TFW4

- EIF3G_VANPO

UniProt

A7TFW4 - EIF3G_VANPO

Protein

Eukaryotic translation initiation factor 3 subunit G

Gene

TIF35

Organism
Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (02 Oct 2007)
      Previous versions | rss
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    Functioni

    Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. This subunit can bind 18S rRNA.UniRule annotation

    GO - Molecular functioni

    1. nucleotide binding Source: InterPro
    2. translation initiation factor activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. formation of translation preinitiation complex Source: UniProtKB-HAMAP
    2. regulation of translational initiation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Eukaryotic translation initiation factor 3 subunit GUniRule annotation
    Short name:
    eIF3gUniRule annotation
    Alternative name(s):
    Eukaryotic translation initiation factor 3 RNA-binding subunitUniRule annotation
    Short name:
    eIF-3 RNA-binding subunitUniRule annotation
    Translation initiation factor eIF3 p33 subunit homologUniRule annotation
    Short name:
    eIF3 p33 homologUniRule annotation
    Gene namesi
    Name:TIF35UniRule annotation
    ORF Names:Kpol_1023p95
    OrganismiVanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)
    Taxonomic identifieri436907 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeVanderwaltozyma
    ProteomesiUP000000267: Unassembled WGS sequence

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. eukaryotic 43S preinitiation complex Source: UniProtKB-HAMAP
    2. eukaryotic 48S preinitiation complex Source: UniProtKB-HAMAP
    3. eukaryotic translation initiation factor 3 complex Source: UniProtKB-HAMAP

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 274274Eukaryotic translation initiation factor 3 subunit GPRO_0000366896Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei168 – 1681PhosphoserineUniRule annotation

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.UniRule annotation

    Protein-protein interaction databases

    STRINGi436907.A7TFW4.

    Structurei

    3D structure databases

    ProteinModelPortaliA7TFW4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini191 – 27080RRMUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the eIF-3 subunit G family.UniRule annotation
    Contains 1 RRM (RNA recognition motif) domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0724.
    KOiK03248.
    OrthoDBiEOG7J44J3.

    Family and domain databases

    Gene3Di3.30.70.330. 1 hit.
    HAMAPiMF_03006. eIF3g.
    InterProiIPR017334. eIF3_g.
    IPR024675. eIF3g_N.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    [Graphical view]
    PANTHERiPTHR10352. PTHR10352. 1 hit.
    PfamiPF12353. eIF3g. 1 hit.
    PF00076. RRM_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037949. Transl_init_eIF-3_RNA-bind. 1 hit.
    SMARTiSM00360. RRM. 1 hit.
    [Graphical view]
    PROSITEiPS50102. RRM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A7TFW4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTEAMNSEVI NNPDGTKTII TYRVENGQKF KITQKVREVH VSEKVHKAVA    50
    SRKQWAKYGE ERNAPPGPNH STTQLGEEVY LRLSRNWKQK EEEETEKAKI 100
    KSDGIISCRL CGNAHYTMNC PFKSIMSDIA ALEDPNAPIE VGSNAVEAPV 150
    ETASSAAAVA SGKYVPPSRR AGAKDPSSDA YRDSRERDDM ATLKITQLNE 200
    NADETTLREE LLFPFGNIPR VVVVRNRETG RSRGLAFVTF SSEEVAEKAR 250
    RLLNGRGFMN LILQVDWSKP KEKE 274
    Length:274
    Mass (Da):30,640
    Last modified:October 2, 2007 - v1
    Checksum:iF772DE449C35E5BB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS480384 Genomic DNA. Translation: EDO18922.1.
    RefSeqiXP_001646780.1. XM_001646730.1.

    Genome annotation databases

    GeneIDi5547242.
    KEGGivpo:Kpol_1023p95.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS480384 Genomic DNA. Translation: EDO18922.1 .
    RefSeqi XP_001646780.1. XM_001646730.1.

    3D structure databases

    ProteinModelPortali A7TFW4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 436907.A7TFW4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5547242.
    KEGGi vpo:Kpol_1023p95.

    Phylogenomic databases

    eggNOGi COG0724.
    KOi K03248.
    OrthoDBi EOG7J44J3.

    Family and domain databases

    Gene3Di 3.30.70.330. 1 hit.
    HAMAPi MF_03006. eIF3g.
    InterProi IPR017334. eIF3_g.
    IPR024675. eIF3g_N.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    [Graphical view ]
    PANTHERi PTHR10352. PTHR10352. 1 hit.
    Pfami PF12353. eIF3g. 1 hit.
    PF00076. RRM_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037949. Transl_init_eIF-3_RNA-bind. 1 hit.
    SMARTi SM00360. RRM. 1 hit.
    [Graphical view ]
    PROSITEi PS50102. RRM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Independent sorting-out of thousands of duplicated gene pairs in two yeast species descended from a whole-genome duplication."
      Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.
      Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 22028 / DSM 70294.

    Entry informationi

    Entry nameiEIF3G_VANPO
    AccessioniPrimary (citable) accession number: A7TFW4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: October 2, 2007
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Translation initiation factors
      List of translation initiation factor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3