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A7TFW4

- EIF3G_VANPO

UniProt

A7TFW4 - EIF3G_VANPO

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Protein
Eukaryotic translation initiation factor 3 subunit G
Gene
TIF35, Kpol_1023p95
Organism
Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. This subunit can bind 18S rRNA By similarity.UniRule annotation

GO - Molecular functioni

  1. nucleotide binding Source: InterPro
  2. translation initiation factor activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. formation of translation preinitiation complex Source: UniProtKB-HAMAP
  2. regulation of translational initiation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit G
Short name:
eIF3g
Alternative name(s):
Eukaryotic translation initiation factor 3 RNA-binding subunit
Short name:
eIF-3 RNA-binding subunit
Translation initiation factor eIF3 p33 subunit homolog
Short name:
eIF3 p33 homolog
Gene namesi
Name:TIF35
ORF Names:Kpol_1023p95
OrganismiVanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)
Taxonomic identifieri436907 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeVanderwaltozyma
ProteomesiUP000000267: Unassembled WGS sequence

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. eukaryotic 43S preinitiation complex Source: UniProtKB-HAMAP
  2. eukaryotic 48S preinitiation complex Source: UniProtKB-HAMAP
  3. eukaryotic translation initiation factor 3 complex Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 274274Eukaryotic translation initiation factor 3 subunit GUniRule annotation
PRO_0000366896Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei168 – 1681Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex By similarity.

Protein-protein interaction databases

STRINGi436907.A7TFW4.

Structurei

3D structure databases

ProteinModelPortaliA7TFW4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini191 – 27080RRM
Add
BLAST

Sequence similaritiesi

Belongs to the eIF-3 subunit G family.

Phylogenomic databases

eggNOGiCOG0724.
KOiK03248.
OrthoDBiEOG7J44J3.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
HAMAPiMF_03006. eIF3g.
InterProiIPR017334. eIF3_g.
IPR024675. eIF3g_N.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PANTHERiPTHR10352. PTHR10352. 1 hit.
PfamiPF12353. eIF3g. 1 hit.
PF00076. RRM_1. 1 hit.
[Graphical view]
PIRSFiPIRSF037949. Transl_init_eIF-3_RNA-bind. 1 hit.
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7TFW4-1 [UniParc]FASTAAdd to Basket

« Hide

MTEAMNSEVI NNPDGTKTII TYRVENGQKF KITQKVREVH VSEKVHKAVA    50
SRKQWAKYGE ERNAPPGPNH STTQLGEEVY LRLSRNWKQK EEEETEKAKI 100
KSDGIISCRL CGNAHYTMNC PFKSIMSDIA ALEDPNAPIE VGSNAVEAPV 150
ETASSAAAVA SGKYVPPSRR AGAKDPSSDA YRDSRERDDM ATLKITQLNE 200
NADETTLREE LLFPFGNIPR VVVVRNRETG RSRGLAFVTF SSEEVAEKAR 250
RLLNGRGFMN LILQVDWSKP KEKE 274
Length:274
Mass (Da):30,640
Last modified:October 2, 2007 - v1
Checksum:iF772DE449C35E5BB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS480384 Genomic DNA. Translation: EDO18922.1.
RefSeqiXP_001646780.1. XM_001646730.1.

Genome annotation databases

GeneIDi5547242.
KEGGivpo:Kpol_1023p95.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS480384 Genomic DNA. Translation: EDO18922.1 .
RefSeqi XP_001646780.1. XM_001646730.1.

3D structure databases

ProteinModelPortali A7TFW4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 436907.A7TFW4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5547242.
KEGGi vpo:Kpol_1023p95.

Phylogenomic databases

eggNOGi COG0724.
KOi K03248.
OrthoDBi EOG7J44J3.

Family and domain databases

Gene3Di 3.30.70.330. 1 hit.
HAMAPi MF_03006. eIF3g.
InterProi IPR017334. eIF3_g.
IPR024675. eIF3g_N.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view ]
PANTHERi PTHR10352. PTHR10352. 1 hit.
Pfami PF12353. eIF3g. 1 hit.
PF00076. RRM_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF037949. Transl_init_eIF-3_RNA-bind. 1 hit.
SMARTi SM00360. RRM. 1 hit.
[Graphical view ]
PROSITEi PS50102. RRM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Independent sorting-out of thousands of duplicated gene pairs in two yeast species descended from a whole-genome duplication."
    Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.
    Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 22028 / DSM 70294.

Entry informationi

Entry nameiEIF3G_VANPO
AccessioniPrimary (citable) accession number: A7TFW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: October 2, 2007
Last modified: February 19, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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