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Protein

Eukaryotic translation initiation factor 3 subunit G

Gene

TIF35

Organism
Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionInitiation factor, RNA-binding
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit GUniRule annotation
Short name:
eIF3gUniRule annotation
Alternative name(s):
Eukaryotic translation initiation factor 3 RNA-binding subunitUniRule annotation
Short name:
eIF-3 RNA-binding subunitUniRule annotation
Translation initiation factor eIF3 p33 subunit homologUniRule annotation
Short name:
eIF3 p33 homologUniRule annotation
Gene namesi
Name:TIF35UniRule annotation
ORF Names:Kpol_1023p95
OrganismiVanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)
Taxonomic identifieri436907 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeVanderwaltozyma
Proteomesi
  • UP000000267 Componenti: Unassembled WGS sequence

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003668961 – 274Eukaryotic translation initiation factor 3 subunit GAdd BLAST274

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei168PhosphoserineUniRule annotation1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiA7TFW4

Interactioni

Subunit structurei

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.UniRule annotation

Protein-protein interaction databases

STRINGi436907.XP_001646780.1

Structurei

3D structure databases

ProteinModelPortaliA7TFW4
SMRiA7TFW4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini191 – 270RRMUniRule annotationAdd BLAST80

Sequence similaritiesi

Belongs to the eIF-3 subunit G family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0122 Eukaryota
ENOG410Y3CW LUCA
InParanoidiA7TFW4
KOiK03248
OrthoDBiEOG092C4BPC
PhylomeDBiA7TFW4

Family and domain databases

CDDicd12933 eIF3G, 1 hit
cd12408 RRM_eIF3G_like, 1 hit
Gene3Di3.30.70.330, 1 hit
HAMAPiMF_03006 eIF3g, 1 hit
InterProiView protein in InterPro
IPR017334 eIF3_g
IPR024675 eIF3g_N
IPR034240 eIF3G_RRM
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PANTHERiPTHR10352:SF0 PTHR10352:SF0, 1 hit
PfamiView protein in Pfam
PF12353 eIF3g, 1 hit
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequencei

Sequence statusi: Complete.

A7TFW4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEAMNSEVI NNPDGTKTII TYRVENGQKF KITQKVREVH VSEKVHKAVA
60 70 80 90 100
SRKQWAKYGE ERNAPPGPNH STTQLGEEVY LRLSRNWKQK EEEETEKAKI
110 120 130 140 150
KSDGIISCRL CGNAHYTMNC PFKSIMSDIA ALEDPNAPIE VGSNAVEAPV
160 170 180 190 200
ETASSAAAVA SGKYVPPSRR AGAKDPSSDA YRDSRERDDM ATLKITQLNE
210 220 230 240 250
NADETTLREE LLFPFGNIPR VVVVRNRETG RSRGLAFVTF SSEEVAEKAR
260 270
RLLNGRGFMN LILQVDWSKP KEKE
Length:274
Mass (Da):30,640
Last modified:October 2, 2007 - v1
Checksum:iF772DE449C35E5BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS480384 Genomic DNA Translation: EDO18922.1
RefSeqiXP_001646780.1, XM_001646730.1

Genome annotation databases

EnsemblFungiiEDO18922; EDO18922; Kpol_1023p95
GeneIDi5547242
KEGGivpo:Kpol_1023p95

Similar proteinsi

Entry informationi

Entry nameiEIF3G_VANPO
AccessioniPrimary (citable) accession number: A7TFW4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: October 2, 2007
Last modified: May 23, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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