ID   A7TFE8_VANPO            Unreviewed;       501 AA.
AC   A7TFE8;
DT   02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT   02-OCT-2007, sequence version 1.
DT   13-SEP-2023, entry version 69.
DE   RecName: Full=Phosphotransferase {ECO:0000256|RuleBase:RU362007};
DE            EC=2.7.1.- {ECO:0000256|RuleBase:RU362007};
GN   ORFNames=Kpol_2002p32 {ECO:0000313|EMBL:EDO18962.1};
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907 {ECO:0000313|Proteomes:UP000000267};
RN   [1] {ECO:0000313|EMBL:EDO18962.1, ECO:0000313|Proteomes:UP000000267}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 /
RC   NRRL Y-8283 / UCD 57-17 {ECO:0000313|Proteomes:UP000000267};
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- SIMILARITY: Belongs to the hexokinase family.
CC       {ECO:0000256|ARBA:ARBA00009225, ECO:0000256|RuleBase:RU362007}.
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DR   EMBL; DS480383; EDO18962.1; -; Genomic_DNA.
DR   RefSeq; XP_001646820.1; XM_001646770.1.
DR   AlphaFoldDB; A7TFE8; -.
DR   STRING; 436907.A7TFE8; -.
DR   GeneID; 5547285; -.
DR   KEGG; vpo:Kpol_2002p32; -.
DR   eggNOG; KOG1369; Eukaryota.
DR   HOGENOM; CLU_014393_5_0_1; -.
DR   InParanoid; A7TFE8; -.
DR   OMA; YHPNCRI; -.
DR   OrthoDB; 5481886at2759; -.
DR   PhylomeDB; A7TFE8; -.
DR   UniPathway; UPA00109; UER00180.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR   GO; GO:0004396; F:hexokinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0001678; P:intracellular glucose homeostasis; IEA:InterPro.
DR   Gene3D; 3.30.420.40; -; 1.
DR   Gene3D; 3.40.367.20; -; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR001312; Hexokinase.
DR   InterPro; IPR022673; Hexokinase_C.
DR   InterPro; IPR022672; Hexokinase_N.
DR   PANTHER; PTHR19443:SF30; GLUCOKINASE-1-RELATED; 1.
DR   PANTHER; PTHR19443; HEXOKINASE; 1.
DR   Pfam; PF00349; Hexokinase_1; 1.
DR   Pfam; PF03727; Hexokinase_2; 1.
DR   PRINTS; PR00475; HEXOKINASE.
DR   SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR   PROSITE; PS51748; HEXOKINASE_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU362007};
KW   Glycolysis {ECO:0000256|RuleBase:RU362007};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU362007};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU362007};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000267};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU362007}.
FT   DOMAIN          17..229
FT                   /note="Hexokinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00349"
FT   DOMAIN          247..500
FT                   /note="Hexokinase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03727"
SQ   SEQUENCE   501 AA;  55955 MW;  E8928711AFBB55E9 CRC64;
     MSFDELHKNI AETLSKEVDS ICQQFTVTET KMQELTDYFI ESMNSGLEPL PEGETEGTQS
     SRLPMIPSYV TGKPNGTEKG LFLAADLGGT NFRVCSVVLN GDQTFTLKNM KNKIPEYLLD
     DENVSSEELF AYLAKRTGVF LKRYYPTIFS NPDGEEELKM GFTFSYPVNQ TSLCSGTLIR
     WTKGFNISDT IGKDVVQLFQ EQLEKEGLKR IKIVALTNDT VGTFLSHCYG SGSSNSLASG
     DVSEPVIGCI FGTGTNGCYM EEIENIKKLP QDVREKLIAS GKTHMIINTE WGSFDNECRH
     LPTTQYDIDI DQKFSTNPGF HLFEKRISGM YLGEILRNII VDLHKRGLIL NQYRSYNQLP
     HRLKTPFELS SEVLSHIEID DSTGLRETEL SLLQSLRLPT SPIEREQIQK LVRAISRRSA
     YLTAIPIAAI LIKTNSLHKR YHGEVEVGCD GSVVEYYPGF RSMMRHALAL SPIGPDGERK
     VHLRIAKDGS GVGAALCALV A
//