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Protein

Hexokinase

Gene

Kpol_2002p32

Organism
Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HexokinaseUniRule annotation (EC:2.7.1.1UniRule annotation)
Gene namesi
ORF Names:Kpol_2002p32Imported
OrganismiVanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)Imported
Taxonomic identifieri436907 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeVanderwaltozyma
ProteomesiUP000000267 Componenti: Unassembled WGS sequence

Interactioni

Protein-protein interaction databases

STRINGi436907.XP_001646820.1.

Structurei

3D structure databases

ProteinModelPortaliA7TFE8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the hexokinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG5026.
InParanoidiA7TFE8.
KOiK00844.
OrthoDBiEOG79SF68.
PhylomeDBiA7TFE8.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PROSITEiPS51748. HEXOKINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7TFE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFDELHKNI AETLSKEVDS ICQQFTVTET KMQELTDYFI ESMNSGLEPL
60 70 80 90 100
PEGETEGTQS SRLPMIPSYV TGKPNGTEKG LFLAADLGGT NFRVCSVVLN
110 120 130 140 150
GDQTFTLKNM KNKIPEYLLD DENVSSEELF AYLAKRTGVF LKRYYPTIFS
160 170 180 190 200
NPDGEEELKM GFTFSYPVNQ TSLCSGTLIR WTKGFNISDT IGKDVVQLFQ
210 220 230 240 250
EQLEKEGLKR IKIVALTNDT VGTFLSHCYG SGSSNSLASG DVSEPVIGCI
260 270 280 290 300
FGTGTNGCYM EEIENIKKLP QDVREKLIAS GKTHMIINTE WGSFDNECRH
310 320 330 340 350
LPTTQYDIDI DQKFSTNPGF HLFEKRISGM YLGEILRNII VDLHKRGLIL
360 370 380 390 400
NQYRSYNQLP HRLKTPFELS SEVLSHIEID DSTGLRETEL SLLQSLRLPT
410 420 430 440 450
SPIEREQIQK LVRAISRRSA YLTAIPIAAI LIKTNSLHKR YHGEVEVGCD
460 470 480 490 500
GSVVEYYPGF RSMMRHALAL SPIGPDGERK VHLRIAKDGS GVGAALCALV

A
Length:501
Mass (Da):55,955
Last modified:October 2, 2007 - v1
Checksum:iE8928711AFBB55E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS480383 Genomic DNA. Translation: EDO18962.1.
RefSeqiXP_001646820.1. XM_001646770.1.

Genome annotation databases

GeneIDi5547285.
KEGGivpo:Kpol_2002p32.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS480383 Genomic DNA. Translation: EDO18962.1.
RefSeqiXP_001646820.1. XM_001646770.1.

3D structure databases

ProteinModelPortaliA7TFE8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi436907.XP_001646820.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5547285.
KEGGivpo:Kpol_2002p32.

Phylogenomic databases

eggNOGiCOG5026.
InParanoidiA7TFE8.
KOiK00844.
OrthoDBiEOG79SF68.
PhylomeDBiA7TFE8.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PROSITEiPS51748. HEXOKINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Independent sorting-out of thousands of duplicated gene pairs in two yeast species descended from a whole-genome duplication."
    Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.
    Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 22028 / DSM 70294Imported.

Entry informationi

Entry nameiA7TFE8_VANPO
AccessioniPrimary (citable) accession number: A7TFE8
Entry historyi
Integrated into UniProtKB/TrEMBL: October 2, 2007
Last sequence update: October 2, 2007
Last modified: June 24, 2015
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.