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Protein

Mitochondrial thiamine pyrophosphate carrier 1

Gene

TPC1

Organism
Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial thiamine pyrophosphate carrier 1
Gene namesi
Name:TPC1
ORF Names:Kpol_1018p133
OrganismiVanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)
Taxonomic identifieri436907 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeVanderwaltozyma
Proteomesi
  • UP000000267 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei19 – 36Helical; Name=1Sequence analysisAdd BLAST18
Transmembranei75 – 91Helical; Name=2Sequence analysisAdd BLAST17
Transmembranei109 – 128Helical; Name=3Sequence analysisAdd BLAST20
Transmembranei163 – 187Helical; Name=4Sequence analysisAdd BLAST25
Transmembranei203 – 219Helical; Name=5Sequence analysisAdd BLAST17
Transmembranei270 – 287Helical; Name=6Sequence analysisAdd BLAST18

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003204751 – 297Mitochondrial thiamine pyrophosphate carrier 1Add BLAST297

Interactioni

Protein-protein interaction databases

STRINGi436907.XP_001647453.1

Structurei

3D structure databases

ProteinModelPortaliA7TDX5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati13 – 94Solcar 1Add BLAST82
Repeati102 – 195Solcar 2Add BLAST94
Repeati196 – 295Solcar 3Add BLAST100

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0752 Eukaryota
ENOG410ZRF1 LUCA
InParanoidiA7TDX5
KOiK15108
OrthoDBiEOG092C3KDM
PhylomeDBiA7TDX5

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

A7TDX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREEDHLRKG EKSHVFESLV SGAIAGLAAR SAIAPLDTLK LRLQLGTDTL
60 70 80 90 100
PHTLKSLIRH EGLLALWKGN LAGSIMYIIY GSVQFGTYSY TNAALLKVCD
110 120 130 140 150
VPPTIHSTLA GAITGMASSL CSYPFDVLRT RLATTTTTTT TATTGRSGRG
160 170 180 190 200
LYQHIERIYI REGLGGFFHG VATSMANVTV STAAMFGTYE GIRARWPETN
210 220 230 240 250
AGTAGAISGV ISRTITFPLD TIRRRLQIRT SSELGQMTNN GYIGKHMQRS
260 270 280 290
AITLCVQIVR DEGVKVLFRG IGLGLLKSVP NTAINLWVYE NLMRVLT
Length:297
Mass (Da):32,264
Last modified:October 2, 2007 - v1
Checksum:i18EA1E9C4C9C6189
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS480378 Genomic DNA Translation: EDO19595.1
RefSeqiXP_001647453.1, XM_001647403.1

Genome annotation databases

EnsemblFungiiEDO19595; EDO19595; Kpol_1018p133
GeneIDi5547958
KEGGivpo:Kpol_1018p133

Entry informationi

Entry nameiTPC1_VANPO
AccessioniPrimary (citable) accession number: A7TDX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 2, 2007
Last modified: January 31, 2018
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health