A7SN31MTAP_NEMVES-methyl-5'-thioadenosine phosphorylase2.4.2.285'-methylthioadenosine phosphorylaseMTA phosphorylaseMTAPMTAPasev1g214799Nematostella vectensisStarlet sea anemoneEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaEdwardsiidaeNematostellaSea anemone genome reveals ancestral eumetazoan gene repertoire and genomic organization.NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.phosphate + S-methyl-5'-thioadenosine = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphateAmino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.Homotrimer.CytoplasmNucleusBelongs to the PNP/MTAP phosphorylase family. MTAP subfamily.CytoplasmGlycosyltransferaseNucleusPurine salvageReference proteomeTransferasephosphatephosphatephosphatesubstratephosphatesubstrateMANVKVKIGIIGGTGVDNPNIMTDRQEKFVDTPFGKPSEPLITGNIQGVECVLIARHGRKHTVMPTDINYRANVWALKEEGCTHIVVTTACGSLTEAYRPGEIVFPDQIIDRTTKRPSTFYDGQTNSPVGVCHIPMHDPYCSVTKQILANEAQKLGIPHHASGVNVVIEGPRFSTRAESRMFRGLGGEIISMTAMPEVALANEAGLCYAAIAMVTDYDCWRDDHAPVTVESVIATFKVNVANAIKILIAAIPEIAAKDWTEIINERKSQVKPPILDSTWVMFIREYRKIGSDDASKLM
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