Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A7SN31

- MTAP_NEMVE

UniProt

A7SN31 - MTAP_NEMVE

Protein

S-methyl-5'-thioadenosine phosphorylase

Gene

v1g214799

Organism
Nematostella vectensis (Starlet sea anemone)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (02 Oct 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.UniRule annotation

    Catalytic activityi

    S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei14 – 141PhosphateUniRule annotation
    Sitei174 – 1741Important for substrate specificityUniRule annotation
    Binding sitei192 – 1921Substrate; via amide nitrogenUniRule annotation
    Binding sitei193 – 1931PhosphateUniRule annotation
    Sitei229 – 2291Important for substrate specificityUniRule annotation

    GO - Molecular functioni

    1. phosphorylase activity Source: InterPro
    2. S-methyl-5-thioadenosine phosphorylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. L-methionine biosynthetic process from methylthioadenosine Source: UniProtKB-HAMAP
    2. purine ribonucleoside salvage Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Purine salvage

    Enzyme and pathway databases

    UniPathwayiUPA00904; UER00873.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    S-methyl-5'-thioadenosine phosphorylaseUniRule annotation (EC:2.4.2.28UniRule annotation)
    Alternative name(s):
    5'-methylthioadenosine phosphorylaseUniRule annotation
    Short name:
    MTA phosphorylaseUniRule annotation
    Short name:
    MTAPUniRule annotation
    Short name:
    MTAPaseUniRule annotation
    Gene namesi
    ORF Names:v1g214799
    OrganismiNematostella vectensis (Starlet sea anemone)
    Taxonomic identifieri45351 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaEdwardsiidaeNematostella
    ProteomesiUP000001593: Unassembled WGS sequence

    Subcellular locationi

    Cytoplasm UniRule annotation. Nucleus UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 298298S-methyl-5'-thioadenosine phosphorylasePRO_0000415121Add
    BLAST

    Interactioni

    Subunit structurei

    Homotrimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi45351.JGI214799.

    Structurei

    3D structure databases

    ProteinModelPortaliA7SN31.
    SMRiA7SN31. Positions 6-275.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni56 – 572Phosphate bindingUniRule annotation
    Regioni89 – 902Phosphate bindingUniRule annotation
    Regioni216 – 2183Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0005.
    HOGENOMiHOG000228987.
    KOiK00772.
    OMAiCEAQLCY.
    OrthoDBiEOG771270.

    Family and domain databases

    Gene3Di3.40.50.1580. 1 hit.
    HAMAPiMF_01963. MTAP.
    InterProiIPR010044. MTAP.
    IPR000845. Nucleoside_phosphorylase_d.
    IPR001369. PNP/MTAP.
    IPR018099. Purine_phosphorylase-2_CS.
    [Graphical view]
    PANTHERiPTHR11904. PTHR11904. 1 hit.
    PfamiPF01048. PNP_UDP_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF53167. SSF53167. 1 hit.
    TIGRFAMsiTIGR01694. MTAP. 1 hit.
    PROSITEiPS01240. PNP_MTAP_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A7SN31-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANVKVKIGI IGGTGVDNPN IMTDRQEKFV DTPFGKPSEP LITGNIQGVE    50
    CVLIARHGRK HTVMPTDINY RANVWALKEE GCTHIVVTTA CGSLTEAYRP 100
    GEIVFPDQII DRTTKRPSTF YDGQTNSPVG VCHIPMHDPY CSVTKQILAN 150
    EAQKLGIPHH ASGVNVVIEG PRFSTRAESR MFRGLGGEII SMTAMPEVAL 200
    ANEAGLCYAA IAMVTDYDCW RDDHAPVTVE SVIATFKVNV ANAIKILIAA 250
    IPEIAAKDWT EIINERKSQV KPPILDSTWV MFIREYRKIG SDDASKLM 298
    Length:298
    Mass (Da):32,721
    Last modified:October 2, 2007 - v1
    Checksum:i4790357944AF347A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS469716 Genomic DNA. Translation: EDO34894.1.
    RefSeqiXP_001626994.1. XM_001626944.1.

    Genome annotation databases

    EnsemblMetazoaiEDO34894; EDO34894; NEMVEDRAFT_v1g214799.
    GeneIDi5506265.
    KEGGinve:NEMVE_v1g214799.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS469716 Genomic DNA. Translation: EDO34894.1 .
    RefSeqi XP_001626994.1. XM_001626944.1.

    3D structure databases

    ProteinModelPortali A7SN31.
    SMRi A7SN31. Positions 6-275.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 45351.JGI214799.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai EDO34894 ; EDO34894 ; NEMVEDRAFT_v1g214799 .
    GeneIDi 5506265.
    KEGGi nve:NEMVE_v1g214799.

    Phylogenomic databases

    eggNOGi COG0005.
    HOGENOMi HOG000228987.
    KOi K00772.
    OMAi CEAQLCY.
    OrthoDBi EOG771270.

    Enzyme and pathway databases

    UniPathwayi UPA00904 ; UER00873 .

    Family and domain databases

    Gene3Di 3.40.50.1580. 1 hit.
    HAMAPi MF_01963. MTAP.
    InterProi IPR010044. MTAP.
    IPR000845. Nucleoside_phosphorylase_d.
    IPR001369. PNP/MTAP.
    IPR018099. Purine_phosphorylase-2_CS.
    [Graphical view ]
    PANTHERi PTHR11904. PTHR11904. 1 hit.
    Pfami PF01048. PNP_UDP_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53167. SSF53167. 1 hit.
    TIGRFAMsi TIGR01694. MTAP. 1 hit.
    PROSITEi PS01240. PNP_MTAP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CH2 X CH6.

    Entry informationi

    Entry nameiMTAP_NEMVE
    AccessioniPrimary (citable) accession number: A7SN31
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 25, 2012
    Last sequence update: October 2, 2007
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3