ID   L2HDH_NEMVE             Reviewed;         456 AA.
AC   A7SMW7;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   16-JUN-2009, entry version 13.
DE   RecName: Full=L-2-hydroxyglutarate dehydrogenase, mitochondrial;
DE            EC=1.1.99.2;
DE   Flags: Precursor;
GN   ORFNames=v1g172254;
OS   Nematostella vectensis (Starlet sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Edwardsiidae; Nematostella.
OX   NCBI_TaxID=45351;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CH2 X CH6;
RX   PubMed=17615350; DOI=10.1126/science.1139158;
RA   Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J.,
RA   Salamov A., Terry A., Shapiro H., Lindquist E., Kapitonov V.V.,
RA   Jurka J., Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E.,
RA   Finnerty J.R., Technau U., Martindale M.Q., Rokhsar D.S.;
RT   "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT   genomic organization.";
RL   Science 317:86-94(2007).
CC   -!- CATALYTIC ACTIVITY: (S)-2-hydroxyglutarate + acceptor = 2-
CC       oxoglutarate + reduced acceptor.
CC   -!- COFACTOR: FAD (By similarity).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion (By similarity).
CC   -!- SIMILARITY: Belongs to the L2HGDH family.
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DR   EMBL; DS469714; EDO34943.1; -; Genomic_DNA.
DR   RefSeq; XP_001627043.1; -.
DR   UniGene; Nve.17279; -.
DR   GeneID; 5506318; -.
DR   KEGG; nve:NEMVE_v1g172254; -.
DR   OMA; A7SMW7; KIVPFRG.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0047545; F:2-hydroxyglutarate dehydrogenase activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR006076; FAD-dep_OxRdtase.
DR   Pfam; PF01266; DAO; 1.
PE   3: Inferred from homology;
KW   Complete proteome; FAD; Flavoprotein; Mitochondrion; Oxidoreductase;
KW   Transit peptide.
FT   TRANSIT       1     20       Mitochondrion (Potential).
FT   CHAIN        21    456       L-2-hydroxyglutarate dehydrogenase,
FT                                mitochondrial.
FT                                /FTId=PRO_0000331209.
SQ   SEQUENCE   456 AA;  50175 MW;  5253882511B4D343 CRC64;
     MLKTSFLLSK RNAVSLSRVL ATGISGRNVR HLTLQPSEHY DVAIVGGGIV GLATARELIL
     RHPKLTFCVL EKEKELSMHQ SGHNSGVIHC GIYYTPGSLK AKLCVQGLDL TYQYCDEHNI
     PYKKCGKLIV AVEDKEIPLL NNLYERGKKN GVKDLTMVDK RGIKEIEPHC EGMFAIVSPN
     TGIVDWAQVA LAYGDDFRKG GGDIFTGYEV TDFKCASESG KSQEKEAGLT HPVTVFSNNK
     QTIKCRYVIT CGGLYSDRLA EKSGCNREPR IVPFRGDYLV LKPEKCHLVK GNIYPVPDPN
     FPFLGVHFTP RMDGSVWLGP NAVLAFAREG YNLLDINLRD LADALAFRGL RQLMFKYFSF
     GVGEYYRGLN HAAQVKQLQK YIPSVTADDV VSGPSGVRAQ ALDRDGNLVD DFVFDGGVGE
     IGSRVLHVRN APSPAATSSL AIARMVADKA AERFTL
//