Reviewed, UniProtKB/Swiss-Prot A7SMW7 (L2HDH_NEMVE)

Names and origin

Protein names

Recommended name:
    L-2-hydroxyglutarate dehydrogenase, mitochondrial
    EC=1.1.99.2

Gene names

ORF Names:

v1g172254

Organism

Nematostella vectensis (Starlet sea anemone) [Complete proteome]

Taxonomic identifier

45351 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Cnidaria › Anthozoa › Hexacorallia › Actiniaria › Edwardsiidae › Nematostella

Protein attributes

Sequence length	456 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	(S)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor.
Cofactor	FAD By similarity.
Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the L2HGDH family.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	2-hydroxyglutarate dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 20	20	Mitochondrion Potential
	Chain	21 – 456	436	L-2-hydroxyglutarate dehydrogenase, mitochondrial		PRO_0000331209

Sequences

	Sequence		Length	Mass (Da)
	A7SMW7-1 [UniParc]. Last modified October 2, 2007. Version 1. Checksum: 5253882511B4D343	FASTA	456	50,175
	10 20 30 40 50 60 MLKTSFLLSK RNAVSLSRVL ATGISGRNVR HLTLQPSEHY DVAIVGGGIV GLATARELIL 70 80 90 100 110 120 RHPKLTFCVL EKEKELSMHQ SGHNSGVIHC GIYYTPGSLK AKLCVQGLDL TYQYCDEHNI 130 140 150 160 170 180 PYKKCGKLIV AVEDKEIPLL NNLYERGKKN GVKDLTMVDK RGIKEIEPHC EGMFAIVSPN 190 200 210 220 230 240 TGIVDWAQVA LAYGDDFRKG GGDIFTGYEV TDFKCASESG KSQEKEAGLT HPVTVFSNNK 250 260 270 280 290 300 QTIKCRYVIT CGGLYSDRLA EKSGCNREPR IVPFRGDYLV LKPEKCHLVK GNIYPVPDPN 310 320 330 340 350 360 FPFLGVHFTP RMDGSVWLGP NAVLAFAREG YNLLDINLRD LADALAFRGL RQLMFKYFSF 370 380 390 400 410 420 GVGEYYRGLN HAAQVKQLQK YIPSVTADDV VSGPSGVRAQ ALDRDGNLVD DFVFDGGVGE 430 440 450 IGSRVLHVRN APSPAATSSL AIARMVADKA AERFTL

References

[1]

"Sea anemone genome reveals ancestral eumetazoan gene repertoire and genomic organization." Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A., Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J., Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R., Technau U., Martindale M.Q., Rokhsar D.S. Science 317:86-94(2007) [PubMed: 17615350] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CH2 X CH6.

Cross-references

Sequence databases
EMBLGenBankDDBJ	DS469714 Genomic DNA. Translation: EDO34943.1.
RefSeq	XP_001627043.1.
UniGene	Nve.17279
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5506318.
KEGG	nve:NEMVE_v1g172254.
Phylogenomic databases
OMA	A7SMW7. KIVPFRG.
Family and domain databases
InterPro	IPR006076. FAD-dep_OxRdtase. [Graphical view]
Pfam	PF01266. DAO. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

L2HDH_NEMVE

Accession

Primary (citable) accession number: A7SMW7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	October 2, 2007
Last modified:	June 16, 2009
This is version 13 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)