A7SLT6 (A7SLT6_NEMVE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
6-phosphogluconate dehydrogenase, decarboxylating PIRNR PIRNR000109 RuleBase RU000485
EC=1.1.1.44 PIRNR PIRNR000109 RuleBase RU000485

Gene names

ORF Names:

v1g230495

Organism

Nematostella vectensis (Starlet sea anemone)

Taxonomic identifier

45351 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Cnidaria › Anthozoa › Hexacorallia › Actiniaria › Edwardsiidae › Nematostella

Protein attributes

Sequence length	484 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity. PIRNR PIRNR000109
Catalytic activity	6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH. PIRNR PIRNR000109 RuleBase RU000485
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. PIRNR PIRNR000109 RuleBase RU004281
Subunit structure	Homodimer By similarity. PIRNR PIRNR000109
Sequence similarities	Belongs to the 6-phosphogluconate dehydrogenase family. PIRNR PIRNR000109 RuleBase RU000485

Ontologies

Keywords
Biological process	Pentose shunt PIRNR PIRNR000109 RuleBase RU004281
Ligand	NADP PIRNR PIRNR000109 RuleBase RU000485
Molecular function	Oxidoreductase PIRNR PIRNR000109 RuleBase RU000485
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	pentose-phosphate shunt Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro phosphogluconate dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	12 – 17	6	NADP By similarity PIRSR PIRSR000109-3
	Nucleotide binding	35 – 37	3	NADP By similarity PIRSR PIRSR000109-3
	Nucleotide binding	77 – 79	3	NADP By similarity PIRSR PIRSR000109-3
	Region	131 – 133	3	Substrate binding By similarity PIRSR PIRSR000109-2
	Region	188 – 189	2	Substrate binding By similarity PIRSR PIRSR000109-2
Sites
	Active site	185	1	Proton acceptor By similarity PIRSR PIRSR000109-1
	Active site	192	1	Proton donor By similarity PIRSR PIRSR000109-1
	Binding site	105	1	NADP By similarity PIRSR PIRSR000109-3
	Binding site	105	1	Substrate By similarity PIRSR PIRSR000109-2
	Binding site	193	1	Substrate By similarity PIRSR PIRSR000109-2
	Binding site	262	1	Substrate; via amide nitrogen By similarity PIRSR PIRSR000109-2
	Binding site	289	1	Substrate By similarity PIRSR PIRSR000109-2
	Binding site	448	1	Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2
	Binding site	454	1	Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2

Sequences

	Sequence		Length	Mass (Da)
	A7SLT6 [UniParc]. Last modified October 2, 2007. Version 1. Checksum: C0E22149A1F4F097	FASTA	484	53,058
	10 20 30 40 50 60 MAEPTADIAL IGLAVMGQNI ILNMNDHGYV VCAHNRTVEK VDRFLANEAK GTRIVGAHSL 70 80 90 100 110 120 QEMVSKLKKP RRVMILVKAG SAVDAFIDHL VPLLESGDII IDGGNSEYKD SMRRCKALEE 130 140 150 160 170 180 RGLLFVGSGV SGGEEGARYG PSLMPGGSEK AWPHIKPIFQ AIAAKAGNDP CCDWVGGDGS 190 200 210 220 230 240 GHFVKMVHNG IEYGDMQLCC EAYHLMKDAL GMTSDEISQV FDEWNKGELD SFLIEITKNI 250 260 270 280 290 300 MAYKDADGSP LVEKIRDSAG QKGTGKWTAI SALEYGMPVT LIGESVFARC LSSLQAERVH 310 320 330 340 350 360 ASTHLKGPAS TKFTGDKKEF VEHIRKALYA SKIVSYAQGF MLMREAAKVF NWKLNYGGIA 370 380 390 400 410 420 LMWRGGCIIR SRFLGNIKDA FNKNPNLDNL LLDDFFKDAI HKCQDSWRKT IATAVTLGIP 430 440 450 460 470 480 TPAFSTALAF YDGYRSARLP ANLIQAQRDY FGAHTYELLS NPGHFIHTNW TGKGGNVSST TYQA

References

[1]

"Sea anemone genome reveals ancestral eumetazoan gene repertoire and genomic organization." Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A., Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J., Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R., Technau U., Martindale M.Q., Rokhsar D.S. Science 317:86-94(2007) [PubMed: 17615350] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CH2 X CH6.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DS469702 Genomic DNA. Translation: EDO35313.1.
RefSeq	XP_001627413.1. XM_001627363.1.
UniGene	Nve.14241.
3D structure databases
ProteinModelPortal	A7SLT6.
SMR	A7SLT6. Positions 6-475.
ModBase	Search...
Protein-protein interaction databases
STRING	A7SLT6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	NEMVEDRAFT_v1g230495-RA; NEMVEDRAFT_v1g230495-PA; NEMVEDRAFT_v1g230495.
GeneID	5506713.
KEGG	nve:NEMVE_v1g230495.
Phylogenomic databases
OMA	MEHNEMA.
PhylomeDB	A7SLT6.
Family and domain databases
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR006114. 6PGDH_C. IPR006113. 6PGDH_decarbox. IPR006115. 6PGDH_NADP-bd. IPR006184. 6PGdom_BS. IPR013328. DH_multihelical. IPR012284. Fibritin/6PGD_C-extension. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KO	K00033.
Pfam	PF00393. 6PGD. 1 hit. PF03446. NAD_binding_2. 1 hit. [Graphical view]
PIRSF	PIRSF000109. 6PGD. 1 hit.
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMs	TIGR00873. Gnd. 1 hit.
PROSITE	PS00461. 6PGD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A7SLT6_NEMVE

Accession

Primary (citable) accession number: A7SLT6

Entry history

Integrated into UniProtKB/TrEMBL:	October 2, 2007
Last sequence update:	October 2, 2007
Last modified:	December 14, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)