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Protein

DNA ligase

Gene

v1g230001

Organism
Nematostella vectensis (Starlet sea anemone)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotation
Biological processDNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:v1g230001Imported
OrganismiNematostella vectensis (Starlet sea anemone)Imported
Taxonomic identifieri45351 [NCBI]
Taxonomic lineageiEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaEdwardsiidaeNematostella
Proteomesi
  • UP000001593 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Interactioni

Protein-protein interaction databases

STRINGi45351.NEMVEDRAFT_v1g230001-PA

Structurei

3D structure databases

ProteinModelPortaliA7SE93
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 100PARP-typeInterPro annotationAdd BLAST93
Domaini533 – 667DNA_LIGASE_A3InterPro annotationAdd BLAST135

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili812 – 839Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG4437 Eukaryota
COG1793 LUCA
HOGENOMiHOG000007653
InParanoidiA7SE93
KOiK10776
OMAiDCIYFND
OrthoDBiEOG091G0XBU

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
3.30.1740.10, 1 hit
3.40.50.10190, 1 hit
InterProiView protein in InterPro
IPR036420 BRCT_dom_sf
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR031916 LIG3_BRCT
IPR012340 NA-bd_OB-fold
IPR001510 Znf_PARP
IPR036957 Znf_PARP_sf
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
PF16759 LIG3_BRCT, 1 hit
PF00645 zf-PARP, 1 hit
SMARTiView protein in SMART
SM01336 zf-PARP, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit
PS00347 PARP_ZN_FINGER_1, 1 hit
PS50064 PARP_ZN_FINGER_2, 1 hit

Sequencei

Sequence statusi: Complete.

A7SE93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEDLKSFLV EYAPQGRAKC KGCKEQIEKS SARIAKLAPN PFSEDGGLMK
60 70 80 90 100
QWYHVKCIFD SFSRARATTK KIEDAEDLDG FVDMKQDDQN TIKQLISGLS
110 120 130 140 150
GKKVSPGKKA SQKPTSSPGQ KKVQGTLTFS PTNTSVRPLM TVAGSSKGTV
160 170 180 190 200
SLLRIKRIAT YLVSQAGRIQ IVTCSNHTAQ IFRRAVAVLR ASDNLSASKA
210 220 230 240 250
GAESSKDDAF REFRKLCVQL AEEPSYNAKT RLVANLLKKG PSGSGFQGDT
260 270 280 290 300
TLWVKMLLPA INKRVYNLQS KQLVKLFSQI FCCNYDDMVT HLEEGGDVSE
310 320 330 340 350
TISNFFTNSI ICKPAKKSNL TLQQVDSFLD RLKLLTKEDD QQRELCSITQ
360 370 380 390 400
RCTSNDLKYI IRLIKHDLRM NAGAKHVLEA IDPDAYKAFQ ASNDLEDVVK
410 420 430 440 450
RCLEKHASSG NDRVPGMSKK LSIRASLMTP VKPMLAEACK TFSYAIKKCP
460 470 480 490 500
KGMLAEIKYD GERVQVHKSG SKFEFFSRSL KPVLPHKVSA FRDFLPKACP
510 520 530 540 550
HGNNLILDCE VLLVDNKTSL PLPFGTLGIH KKSAFKDANV CLFIFDCLQF
560 570 580 590 600
NEENVMRKSM TERRKILEEN VTVIPNRIML SETTFVKDEK KLSQLMARAM
610 620 630 640 650
RDGLEGLVLK DVTGQYEPGK RHWLKMKKDY LEEGSMADTA DLVVLGAYYG
660 670 680 690 700
TGNKGGLMSV FLMGVFNPRI KKWCTVAKCG NGHDDKTLDK LNRELKVKKI
710 720 730 740 750
SKDPNRVPVW LEVHRSLIPD FVVDDPKKAP VWEITGAEFS KSTTHTADGI
760 770 780 790 800
SIRFPRVTRI RDDKDWETAT DLDLLKPVVH LHAPLWPDNH RMRMYNTKNE
810 820 830 840 850
DEPMDSDETV DNDDVTERKS SAKRKANQIE NDKDEASDRK ELPNVFSGLQ
860 870 880 890
VYVPDTIKDF NKLRRYIIAS RYDGDVVTDK STATHIIANS KVTP
Length:894
Mass (Da):100,451
Last modified:October 2, 2007 - v1
Checksum:iA25E5D5D3781C802
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS469635 Genomic DNA Translation: EDO37995.1
RefSeqiXP_001630058.1, XM_001630008.1

Genome annotation databases

EnsemblMetazoaiEDO37995; EDO37995; NEMVEDRAFT_v1g230001
GeneIDi5509532
KEGGinve:NEMVE_v1g230001

Similar proteinsi

Entry informationi

Entry nameiA7SE93_NEMVE
AccessioniPrimary (citable) accession number: A7SE93
Entry historyiIntegrated into UniProtKB/TrEMBL: October 2, 2007
Last sequence update: October 2, 2007
Last modified: March 28, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health