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A7SE05 (UBE2S_NEMVE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin-conjugating enzyme E2 S

EC=6.3.2.19
Alternative name(s):
Ubiquitin carrier protein S
Ubiquitin-protein ligase S
Gene names
ORF Names:v1g237158
OrganismNematostella vectensis (Starlet sea anemone) [Reference proteome]
Taxonomic identifier45351 [NCBI]
Taxonomic lineageEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaEdwardsiidaeNematostella

Protein attributes

Sequence length204 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating polyubiquitin chains initiated by the E2 enzyme UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit By similarity.

Catalytic activity

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathway

Protein modification; protein ubiquitination.

Sequence similarities

Belongs to the ubiquitin-conjugating enzyme family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 204204Ubiquitin-conjugating enzyme E2 S
PRO_0000390436

Sites

Active site981Glycyl thioester intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
A7SE05 [UniParc].

Last modified October 2, 2007. Version 1.
Checksum: 3C1A377D16C59F8F

FASTA20422,620
        10         20         30         40         50         60 
MATTSSNVEN FSPQIIKQVA REIHGLTNDP PEGIKVFSND EDITDIQASI EGPTGTPYEG 

        70         80         90        100        110        120 
GIFKIKLVLG KDFPAAPPKG FFLTKIFHPN VAKNGEICVN TLKKDWKPDL GIKQVLLTVK 

       130        140        150        160        170        180 
CLLIVPNPES ALNEEAGKLL LERYDDYSKR AKMFTEIHAK LSASSSNNIS EGQQESLPGK 

       190        200 
KRVAVNEKMC DKKKKDKKRA LKRL 

« Hide

References

[1]"Sea anemone genome reveals ancestral eumetazoan gene repertoire and genomic organization."
Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A., Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J., Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R., Technau U., Martindale M.Q., Rokhsar D.S.
Science 317:86-94(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CH2 X CH6.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS469633 Genomic DNA. Translation: EDO38105.1.
RefSeqXP_001630168.1. XM_001630118.1.
UniGeneNve.13849.

3D structure databases

ProteinModelPortalA7SE05.
SMRA7SE05. Positions 9-159.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING45351.JGI237158.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaEDO38105; EDO38105; NEMVEDRAFT_v1g237158.
GeneID5509668.
KEGGnve:NEMVE_v1g237158.

Phylogenomic databases

eggNOGCOG5078.
HOGENOMHOG000233455.
KOK10583.
OMAPDLGIKH.
OrthoDBEOG73JKXD.

Enzyme and pathway databases

UniPathwayUPA00143.

Family and domain databases

Gene3D3.10.110.10. 1 hit.
InterProIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMSSF54495. SSF54495. 1 hit.
PROSITEPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUBE2S_NEMVE
AccessionPrimary (citable) accession number: A7SE05
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 2009
Last sequence update: October 2, 2007
Last modified: June 11, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways