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A7SE05

- UBE2S_NEMVE

UniProt

A7SE05 - UBE2S_NEMVE

Protein

Ubiquitin-conjugating enzyme E2 S

Gene

v1g237158

Organism
Nematostella vectensis (Starlet sea anemone)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (02 Oct 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating polyubiquitin chains initiated by the E2 enzyme UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit By similarity.PROSITE-ProRule annotation

    Catalytic activityi

    ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei98 – 981Glycyl thioester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. acid-amino acid ligase activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. activation of anaphase-promoting complex activity Source: UniProtKB
    2. anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
    3. exit from mitosis Source: UniProtKB
    4. free ubiquitin chain polymerization Source: UniProtKB
    5. protein K11-linked ubiquitination Source: UniProtKB

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Cell cycle, Cell division, Ubl conjugation pathway

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin-conjugating enzyme E2 S (EC:6.3.2.19)
    Alternative name(s):
    Ubiquitin carrier protein S
    Ubiquitin-protein ligase S
    Gene namesi
    ORF Names:v1g237158
    OrganismiNematostella vectensis (Starlet sea anemone)
    Taxonomic identifieri45351 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaEdwardsiidaeNematostella
    ProteomesiUP000001593: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. anaphase-promoting complex Source: UniProtKB

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 204204Ubiquitin-conjugating enzyme E2 SPRO_0000390436Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi45351.JGI237158.

    Structurei

    3D structure databases

    ProteinModelPortaliA7SE05.
    SMRiA7SE05. Positions 9-159.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5078.
    HOGENOMiHOG000233455.
    KOiK10583.
    OMAiPDLGIKH.
    OrthoDBiEOG73JKXD.

    Family and domain databases

    Gene3Di3.10.110.10. 1 hit.
    InterProiIPR000608. UBQ-conjugat_E2.
    IPR023313. UBQ-conjugating_AS.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view]
    PfamiPF00179. UQ_con. 1 hit.
    [Graphical view]
    SUPFAMiSSF54495. SSF54495. 1 hit.
    PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
    PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A7SE05-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATTSSNVEN FSPQIIKQVA REIHGLTNDP PEGIKVFSND EDITDIQASI    50
    EGPTGTPYEG GIFKIKLVLG KDFPAAPPKG FFLTKIFHPN VAKNGEICVN 100
    TLKKDWKPDL GIKQVLLTVK CLLIVPNPES ALNEEAGKLL LERYDDYSKR 150
    AKMFTEIHAK LSASSSNNIS EGQQESLPGK KRVAVNEKMC DKKKKDKKRA 200
    LKRL 204
    Length:204
    Mass (Da):22,620
    Last modified:October 2, 2007 - v1
    Checksum:i3C1A377D16C59F8F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS469633 Genomic DNA. Translation: EDO38105.1.
    RefSeqiXP_001630168.1. XM_001630118.1.
    UniGeneiNve.13849.

    Genome annotation databases

    EnsemblMetazoaiEDO38105; EDO38105; NEMVEDRAFT_v1g237158.
    GeneIDi5509668.
    KEGGinve:NEMVE_v1g237158.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS469633 Genomic DNA. Translation: EDO38105.1 .
    RefSeqi XP_001630168.1. XM_001630118.1.
    UniGenei Nve.13849.

    3D structure databases

    ProteinModelPortali A7SE05.
    SMRi A7SE05. Positions 9-159.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 45351.JGI237158.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai EDO38105 ; EDO38105 ; NEMVEDRAFT_v1g237158 .
    GeneIDi 5509668.
    KEGGi nve:NEMVE_v1g237158.

    Phylogenomic databases

    eggNOGi COG5078.
    HOGENOMi HOG000233455.
    KOi K10583.
    OMAi PDLGIKH.
    OrthoDBi EOG73JKXD.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Family and domain databases

    Gene3Di 3.10.110.10. 1 hit.
    InterProi IPR000608. UBQ-conjugat_E2.
    IPR023313. UBQ-conjugating_AS.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view ]
    Pfami PF00179. UQ_con. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54495. SSF54495. 1 hit.
    PROSITEi PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
    PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CH2 X CH6.

    Entry informationi

    Entry nameiUBE2S_NEMVE
    AccessioniPrimary (citable) accession number: A7SE05
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 2009
    Last sequence update: October 2, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3