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A7SCH8

- KYNU_NEMVE

UniProt

A7SCH8 - KYNU_NEMVE

Protein

Kynureninase

Gene

kynu

Organism
Nematostella vectensis (Starlet sea anemone)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (02 Oct 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

    Catalytic activityi

    L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation
    L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei133 – 1331Pyridoxal phosphate; via amide nitrogenUniRule annotation
    Binding sitei134 – 1341Pyridoxal phosphateUniRule annotation
    Binding sitei217 – 2171Pyridoxal phosphateUniRule annotation
    Binding sitei246 – 2461Pyridoxal phosphateUniRule annotation
    Binding sitei249 – 2491Pyridoxal phosphateUniRule annotation
    Binding sitei271 – 2711Pyridoxal phosphateUniRule annotation
    Binding sitei302 – 3021Pyridoxal phosphateUniRule annotation
    Binding sitei330 – 3301Pyridoxal phosphateUniRule annotation

    GO - Molecular functioni

    1. kynureninase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
    2. anthranilate metabolic process Source: UniProtKB-HAMAP
    3. L-kynurenine catabolic process Source: UniProtKB-UniPathway
    4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
    5. tryptophan catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    UniPathwayiUPA00253; UER00329.
    UPA00334; UER00455.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
    Alternative name(s):
    L-kynurenine hydrolaseUniRule annotation
    Gene namesi
    Name:kynuUniRule annotation
    ORF Names:v1g235255
    OrganismiNematostella vectensis (Starlet sea anemone)
    Taxonomic identifieri45351 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaEdwardsiidaeNematostella
    ProteomesiUP000001593: Unassembled WGS sequence

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 465465KynureninasePRO_0000361088Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei272 – 2721N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi45351.JGI235255.

    Structurei

    3D structure databases

    ProteinModelPortaliA7SCH8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni161 – 1644Pyridoxal phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the kynureninase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG3844.
    HOGENOMiHOG000242438.
    KOiK01556.
    OMAiITESGHK.
    OrthoDBiEOG7D2FDV.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPiMF_01970. Kynureninase.
    InterProiIPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR14084. PTHR14084. 1 hit.
    PfamiPF00266. Aminotran_5. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038800. KYNU. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01814. kynureninase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A7SCH8-1 [UniParc]FASTAAdd to Basket

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    MAYKPTQTLR KLAEKSSLDI VSREFADYMD SKDPLRKMRD EFFYPRVKDL    50
    PGVDLSLVDG DQDSIYFCGN SLGLQPRGCR ELIDRSLTKW EQMGVLGHTS 100
    GWCPWKPIED ILIKPMAEII GAKDIEVVAM NTLTVNLHMM MVPFYRPTPQ 150
    RYKILMEGKA FPSDQYAAQS QVHFHGFDPD KDIIEVFPRE GEQSLRTEDI 200
    LSAIEEHGNS ITLVLFSGVQ YYTGQFFDMK TITAAAQKKG CVVGWDLAHA 250
    VGNVELHLHD WNVDFACWCT YKYLNSGPGG IAGAFVHEKH AYNFELPKFA 300
    GWWGTDRNSR FQMRKEFEQI PGAHGYQCSN PPVFQCLLLR ASLDVFEKTS 350
    VKEIRAKGDL LTAYLELLLL HYFSPSNDIT KNGNTPHVSI ITPADPKDRG 400
    CQLSVKFSVP VDKVFEELCK RGFVGDIRHP DVMRIAPAPL YNSFADVHRF 450
    ISMLNAAFKT ITPNS 465
    Length:465
    Mass (Da):52,709
    Last modified:October 2, 2007 - v1
    Checksum:i4F52CE41A24A5D9C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS469623 Genomic DNA. Translation: EDO38606.1.
    RefSeqiXP_001630669.1. XM_001630619.1.
    UniGeneiNve.12420.

    Genome annotation databases

    EnsemblMetazoaiEDO38606; EDO38606; NEMVEDRAFT_v1g235255.
    GeneIDi5510175.
    KEGGinve:NEMVE_v1g235255.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS469623 Genomic DNA. Translation: EDO38606.1 .
    RefSeqi XP_001630669.1. XM_001630619.1.
    UniGenei Nve.12420.

    3D structure databases

    ProteinModelPortali A7SCH8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 45351.JGI235255.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai EDO38606 ; EDO38606 ; NEMVEDRAFT_v1g235255 .
    GeneIDi 5510175.
    KEGGi nve:NEMVE_v1g235255.

    Phylogenomic databases

    eggNOGi COG3844.
    HOGENOMi HOG000242438.
    KOi K01556.
    OMAi ITESGHK.
    OrthoDBi EOG7D2FDV.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00329 .
    UPA00334 ; UER00455 .

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPi MF_01970. Kynureninase.
    InterProi IPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR14084. PTHR14084. 1 hit.
    Pfami PF00266. Aminotran_5. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038800. KYNU. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01814. kynureninase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CH2 X CH6.

    Entry informationi

    Entry nameiKYNU_NEMVE
    AccessioniPrimary (citable) accession number: A7SCH8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 20, 2009
    Last sequence update: October 2, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3