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Protein

Elongator complex protein 3

Gene

v1g168258

Organism
Nematostella vectensis (Starlet sea anemone)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation.UniRule annotation

Catalytic activityi

Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine.UniRule annotation

Cofactori

[4Fe-4S] clusterUniRule annotationNote: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotation, Transferase
Biological processTranscription, Transcription regulationUniRule annotation
LigandIron, Iron-sulfurUniRule annotation, Metal-binding, S-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Elongator complex protein 3UniRule annotation (EC:2.3.1.48UniRule annotation)
Gene namesi
ORF Names:v1g168258Imported
OrganismiNematostella vectensis (Starlet sea anemone)Imported
Taxonomic identifieri45351 [NCBI]
Taxonomic lineageiEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaEdwardsiidaeNematostella
Proteomesi
  • UP000001593 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Interactioni

Protein-protein interaction databases

STRINGi45351.NEMVEDRAFT_v1g168258-PA

Structurei

3D structure databases

ProteinModelPortaliA7SA82
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini398 – 549N-acetyltransferaseInterPro annotationAdd BLAST152

Sequence similaritiesi

Belongs to the ELP3 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2535 Eukaryota
COG1243 LUCA
HOGENOMiHOG000227514
InParanoidiA7SA82
KOiK07739
OMAiSYTGKEP
OrthoDBiEOG091G03ZS

Family and domain databases

Gene3Di3.80.30.20, 1 hit
InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR034687 ELP3-like
IPR006638 Elp3/MiaB/NifB
IPR000182 GNAT_dom
IPR032432 Radical_SAM_C
IPR007197 rSAM
IPR023404 rSAM_horseshoe
PANTHERiPTHR11135:SF0 PTHR11135:SF0, 1 hit
PfamiView protein in Pfam
PF00583 Acetyltransf_1, 1 hit
PF04055 Radical_SAM, 1 hit
PF16199 Radical_SAM_C, 1 hit
PIRSFiPIRSF005669 Hist_AcTrfase_ELP3, 1 hit
SFLDiSFLDF00344 ELP3-like, 1 hit
SMARTiView protein in SMART
SM00729 Elp3, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit
TIGRFAMsiTIGR01211 ELP3, 1 hit
PROSITEiView protein in PROSITE
PS51186 GNAT, 1 hit

Sequencei

Sequence statusi: Complete.

A7SA82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKKNKKEPV ASRAELMVMT VSDIVNQLIT AHEKGENINL NKVKGKAASK
60 70 80 90 100
YGLASQPRLV DIIAAIPHSH RKVLLPKLKA KPVRTASGIA VVAVMCKPHR
110 120 130 140 150
CPHINMTGNI CVYCPGGPDS DFEYSTQSYT GYEPTSMRAI RARYNPYLQT
160 170 180 190 200
KHRVEQLKQL GHSVDKVEFI VMGGTFMCLD EGYRDFFIRN LHDALSGHTS
210 220 230 240 250
NNVEEAVKYS ERSKTKCIGI TIETRPDYCL KKHLSSMLAY GCTRLEIGVQ
260 270 280 290 300
SVYEDVARDT NRGHTVRAVC ESFHQSKDAG FKVVSHMMPD LPNVGLERDI
310 320 330 340 350
DQFIEFFENP AFRADGLKIY PTLVIRGTGL YELWKTGRYK SYPPNTLVDL
360 370 380 390 400
IARILALVPP WTRVYRVQRD IPMPLVSSGV EHGNLRELAL ARMKDLGTQC
410 420 430 440 450
RDVRTREVGI QEIHHKVRPF EIEQIRRDYV ANGGWETFLS YEDPEQDILI
460 470 480 490 500
GLLRLRKCSD QSFRPELKDR CSIVRELHVY GSVVPVSARD PSKFQHQGFG
510 520 530 540
MLLMEEAERI AREEHGSIKI AVISGVGTRN YYRKLGYELE GPYMVKSLI
Length:549
Mass (Da):62,273
Last modified:October 2, 2007 - v1
Checksum:i95EE52920732544D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS469607 Genomic DNA Translation: EDO39414.1
RefSeqiXP_001631477.1, XM_001631427.1
UniGeneiNve.4852

Genome annotation databases

EnsemblMetazoaiEDO39414; EDO39414; NEMVEDRAFT_v1g168258
GeneIDi5511066
KEGGinve:NEMVE_v1g168258

Similar proteinsi

Entry informationi

Entry nameiA7SA82_NEMVE
AccessioniPrimary (citable) accession number: A7SA82
Entry historyiIntegrated into UniProtKB/TrEMBL: October 2, 2007
Last sequence update: October 2, 2007
Last modified: March 28, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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