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Protein

Elongator complex protein 3

Gene

v1g168258

Organism
Nematostella vectensis (Starlet sea anemone)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation.UniRule annotation

Catalytic activityi

Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine.UniRule annotation

Cofactori

[4Fe-4S] clusterUniRule annotationNote: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotation, Transferase
Biological processTranscription, Transcription regulationUniRule annotation
LigandIron, Iron-sulfurUniRule annotation, Metal-binding, S-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Elongator complex protein 3UniRule annotation (EC:2.3.1.48UniRule annotation)
Gene namesi
ORF Names:v1g168258Imported
OrganismiNematostella vectensis (Starlet sea anemone)Imported
Taxonomic identifieri45351 [NCBI]
Taxonomic lineageiEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaEdwardsiidaeNematostella
Proteomesi
  • UP000001593 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Interactioni

Protein-protein interaction databases

STRINGi45351.NEMVEDRAFT_v1g168258-PA.

Structurei

3D structure databases

ProteinModelPortaliA7SA82.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini398 – 549N-acetyltransferaseInterPro annotationAdd BLAST152

Sequence similaritiesi

Belongs to the ELP3 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2535. Eukaryota.
COG1243. LUCA.
HOGENOMiHOG000227514.
InParanoidiA7SA82.
KOiK07739.
OMAiKIVAHMM.
OrthoDBiEOG091G03ZS.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiView protein in InterPro
IPR016181. Acyl_CoA_acyltransferase.
IPR013785. Aldolase_TIM.
IPR006638. Elp3/MiaB/NifB.
IPR000182. GNAT_dom.
IPR005910. Hist_AcTrfase_ELP3.
IPR032432. Radical_SAM_C.
IPR007197. rSAM.
PfamiView protein in Pfam
PF00583. Acetyltransf_1. 1 hit.
PF04055. Radical_SAM. 1 hit.
PF16199. Radical_SAM_C. 1 hit.
PIRSFiPIRSF005669. Hist_AcTrfase_ELP3. 1 hit.
SMARTiView protein in SMART
SM00729. Elp3. 1 hit.
SUPFAMiSSF55729. SSF55729. 1 hit.
TIGRFAMsiTIGR01211. ELP3. 1 hit.
PROSITEiView protein in PROSITE
PS51186. GNAT. 1 hit.

Sequencei

Sequence statusi: Complete.

A7SA82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKKNKKEPV ASRAELMVMT VSDIVNQLIT AHEKGENINL NKVKGKAASK
60 70 80 90 100
YGLASQPRLV DIIAAIPHSH RKVLLPKLKA KPVRTASGIA VVAVMCKPHR
110 120 130 140 150
CPHINMTGNI CVYCPGGPDS DFEYSTQSYT GYEPTSMRAI RARYNPYLQT
160 170 180 190 200
KHRVEQLKQL GHSVDKVEFI VMGGTFMCLD EGYRDFFIRN LHDALSGHTS
210 220 230 240 250
NNVEEAVKYS ERSKTKCIGI TIETRPDYCL KKHLSSMLAY GCTRLEIGVQ
260 270 280 290 300
SVYEDVARDT NRGHTVRAVC ESFHQSKDAG FKVVSHMMPD LPNVGLERDI
310 320 330 340 350
DQFIEFFENP AFRADGLKIY PTLVIRGTGL YELWKTGRYK SYPPNTLVDL
360 370 380 390 400
IARILALVPP WTRVYRVQRD IPMPLVSSGV EHGNLRELAL ARMKDLGTQC
410 420 430 440 450
RDVRTREVGI QEIHHKVRPF EIEQIRRDYV ANGGWETFLS YEDPEQDILI
460 470 480 490 500
GLLRLRKCSD QSFRPELKDR CSIVRELHVY GSVVPVSARD PSKFQHQGFG
510 520 530 540
MLLMEEAERI AREEHGSIKI AVISGVGTRN YYRKLGYELE GPYMVKSLI
Length:549
Mass (Da):62,273
Last modified:October 2, 2007 - v1
Checksum:i95EE52920732544D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS469607 Genomic DNA. Translation: EDO39414.1.
RefSeqiXP_001631477.1. XM_001631427.1.
UniGeneiNve.4852.

Genome annotation databases

EnsemblMetazoaiEDO39414; EDO39414; NEMVEDRAFT_v1g168258.
GeneIDi5511066.
KEGGinve:NEMVE_v1g168258.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiA7SA82_NEMVE
AccessioniPrimary (citable) accession number: A7SA82
Entry historyiIntegrated into UniProtKB/TrEMBL: October 2, 2007
Last sequence update: October 2, 2007
Last modified: July 5, 2017
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported