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A7S9Y7 (A7S9Y7_NEMVE) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Proteasome subunit alpha type RuleBase RU000551
EC=3.4.25.1 RuleBase RU000551
Gene names
ORF Names:v1g168163
OrganismNematostella vectensis (Starlet sea anemone)
Taxonomic identifier45351 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Cnidaria › Anthozoa › Hexacorallia › Actiniaria › Edwardsiidae › Nematostella

Protein attributes

Sequence length242 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity By similarity. RuleBase RU000551

Catalytic activity

Cleavage of peptide bonds with very broad specificity. RuleBase RU000551

Subunit structure

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits By similarity. RuleBase RU000551

Subcellular location

Cytoplasm. Nucleus By similarity RuleBase RU000551.

Sequence similarities

Belongs to the peptidase T1A family. RuleBase RU000551

Sequences

Sequence LengthMass (Da)Tools
A7S9Y7 [UniParc].

Last modified October 2, 2007. Version 1.
Checksum: DEE184234CBAD9DD

FASTA24226,609
        10         20         30         40         50         60 
MFLTRSEYDR GVNTFSPEGR LFQVEYAIEA IKLGSTAIGI QTSEGVVVAV EKRITSPLME 

        70         80         90        100        110        120 
SSSVEKIVEI DSHIGCAMSG LIADSRTMID KARVEAQNHW FTYNESMSLE SITQAVSNLA 

       130        140        150        160        170        180 
LEFGDDDARE GAMSRPFGVA LLFGGFDEKG PQLFHLDPSG TFIQYDAKAI GSGSEGAQHA 

       190        200        210        220        230        240 
LQETYHQSMT LSEACKSALT ILKQVMEEKL NATNVELATV TKDNKFRMHT KEELEALVKD 


IK

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References

[1]"Sea anemone genome reveals ancestral eumetazoan gene repertoire and genomic organization."
Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A., Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J., Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R., Technau U., Martindale M.Q., Rokhsar D.S.
Science 317:86-94(2007) [PubMed: 17615350] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CH2 X CH6.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		DS469606 Genomic DNA. Translation: EDO39466.1.
RefSeqXP_001631529.1. XM_001631479.1.
UniGeneNve.9356.

3D structure databases

ProteinModelPortalA7S9Y7.
SMRA7S9Y7. Positions 8-241.
ModBaseSearch...

Protein-protein interaction databases

STRINGA7S9Y7.

Protein family/group databases

MEROPST01.975.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaNEMVEDRAFT_v1g168163-RA; NEMVEDRAFT_v1g168163-PA; NEMVEDRAFT_v1g168163.
GeneID5511121.
KEGGnve:NEMVE_v1g168163.

Phylogenomic databases

OMAVEYSLEA.
PhylomeDBA7S9Y7.

Family and domain databases

InterProIPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view]
KOK02729.
PfamPF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view]
SMARTSM00948. Proteasome_A_N. 1 hit.
[Graphical view]
PROSITEPS00388. PROTEASOME_A_1. 1 hit.
PS51475. PROTEASOME_A_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA7S9Y7_NEMVE
AccessionPrimary (citable) accession number: A7S9Y7
Entry history
Integrated into UniProtKB/TrEMBL: October 2, 2007
Last sequence update: October 2, 2007
Last modified: January 25, 2012
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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