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Protein

Thymidine kinase

Gene

v1g243527

Organism
Nematostella vectensis (Starlet sea anemone)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. thymidine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
ORF Names:v1g243527Imported
OrganismiNematostella vectensis (Starlet sea anemone)Imported
Taxonomic identifieri45351 [NCBI]
Taxonomic lineageiEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaEdwardsiidaeNematostella
ProteomesiUP000001593: Unassembled WGS sequence

Interactioni

Protein-protein interaction databases

STRINGi45351.JGI243527.

Structurei

3D structure databases

ProteinModelPortaliA7S8B0.
SMRiA7S8B0. Positions 23-194.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1435.
HOGENOMiHOG000076390.
InParanoidiA7S8B0.
KOiK00857.
OMAiGMATHDK.
OrthoDBiEOG7MSMPX.

Family and domain databases

InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7S8B0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALVTIPGLQ HLHRHHSISE CPGQIQVIFG PMFSGKTTEL LRRIKRYQVA
60 70 80 90 100
NHKCLLIKYA KDIRYDEEGV ATHDRQILRA TPCTVLEDLK NKAINHSVIG
110 120 130 140 150
IDEGQFFPDI VEFSEEMASE GKTIIIAALD GTFQRKAFGN ILHLVPLAES
160 170 180 190 200
VVKLSAVCMN CFKDASFTKR LGYDKRVEVI GGADKYMSVC RECYNLAEVQ
210
ELLSKHSKFQ TH
Length:212
Mass (Da):23,920
Last modified:October 2, 2007 - v1
Checksum:i9E1AE970E6ABD1C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS469597 Genomic DNA. Translation: EDO40073.1.
RefSeqiXP_001632136.1. XM_001632086.1.
UniGeneiNve.8375.

Genome annotation databases

EnsemblMetazoaiEDO40073; EDO40073; NEMVEDRAFT_v1g243527.
GeneIDi5511757.
KEGGinve:NEMVE_v1g243527.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS469597 Genomic DNA. Translation: EDO40073.1.
RefSeqiXP_001632136.1. XM_001632086.1.
UniGeneiNve.8375.

3D structure databases

ProteinModelPortaliA7S8B0.
SMRiA7S8B0. Positions 23-194.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi45351.JGI243527.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiEDO40073; EDO40073; NEMVEDRAFT_v1g243527.
GeneIDi5511757.
KEGGinve:NEMVE_v1g243527.

Phylogenomic databases

eggNOGiCOG1435.
HOGENOMiHOG000076390.
InParanoidiA7S8B0.
KOiK00857.
OMAiGMATHDK.
OrthoDBiEOG7MSMPX.

Family and domain databases

InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CH2 X CH6Imported.

Entry informationi

Entry nameiA7S8B0_NEMVE
AccessioniPrimary (citable) accession number: A7S8B0
Entry historyi
Integrated into UniProtKB/TrEMBL: October 2, 2007
Last sequence update: October 2, 2007
Last modified: January 7, 2015
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.