A7S4N4 (SERIC_NEMVE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable serine incorporator

Gene names

Name:	serinc
ORF Names:	v1g242820

Organism

Nematostella vectensis (Starlet sea anemone) [Reference proteome]

Taxonomic identifier

45351 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Cnidaria › Anthozoa › Hexacorallia › Actiniaria › Edwardsiidae › Nematostella

Protein attributes

Sequence length	456 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Enhances the incorporation of serine into phosphatidylserine and sphingolipids By similarity.
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the TDE1 family.

Ontologies

Keywords
Biological process	Lipid biosynthesis Lipid metabolism Phospholipid biosynthesis Phospholipid metabolism
Cellular component	Endoplasmic reticulum Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 456	456	Probable serine incorporator		PRO_0000342157
Regions
	Transmembrane	10 – 32	23	Helical; Potential
	Transmembrane	44 – 64	21	Helical; Potential
	Transmembrane	95 – 115	21	Helical; Potential
	Transmembrane	126 – 146	21	Helical; Potential
	Transmembrane	153 – 173	21	Helical; Potential
	Transmembrane	195 – 215	21	Helical; Potential
	Transmembrane	234 – 254	21	Helical; Potential
	Transmembrane	265 – 285	21	Helical; Potential
	Transmembrane	301 – 321	21	Helical; Potential
	Transmembrane	383 – 403	21	Helical; Potential
	Transmembrane	430 – 450	21	Helical; Potential
	Compositional bias	8 – 36	29	Cys-rich

Sequences

	Sequence		Length	Mass (Da)
	A7S4N4 [UniParc]. Last modified October 2, 2007. Version 1. Checksum: 9C3001AE47B1A2B8	FASTA	456	50,341
	10 20 30 40 50 60 MGAVLGACTA ASCAANLACC CGSAACSLCC NFCPTCKNST STRIVYSIFL LFGLVVSCIV 70 80 90 100 110 120 LAPGIRHKLN QIPYLCEHAS ETCDSIVGYL AVYRVCFGLA AFFLLFCLLM YGVTSSRDVR 130 140 150 160 170 180 SKIQNGFWGI KILLFLGAIV AAFFIPQGKF SEVWMYFGLI GSFLFILIQL VLLVDFAHTW 190 200 210 220 230 240 NSSWVGRMEE SGSKVWAVLL LCATFLMYGF CVAGIVCLYV YFTYSQESSC HTNKFFISFN 250 260 270 280 290 300 LILCIIASVL AIHPKVQERL PTSGLLQASV ISLYTVYLTW SALSFQPDKN CNGFYETHIT 310 320 330 340 350 360 LAGMDSQAII GVILMFVMVV YASVRTASSS QVGKLGMSSP KHSSALDKET TVLSEGDETR 370 380 390 400 410 420 SDVGLVEEGG EGRRVYDDED GGVAYSYSFY HFMLMLASLY IMMTLTNWYK PVGSDFSKLQ 430 440 450 YSETAVWVKI ASSWLCQLIY IWTLLAPALF PDRDFS

References

[1]

"Sea anemone genome reveals ancestral eumetazoan gene repertoire and genomic organization." Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A., Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J., Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R., Technau U., Martindale M.Q., Rokhsar D.S. Science 317:86-94(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CH2 X CH6.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DS469579 Genomic DNA. Translation: EDO41353.1.
RefSeq	XP_001633416.1. XM_001633366.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	NEMVEDRAFT_v1g242820-RA; NEMVEDRAFT_v1g242820-PA; NEMVEDRAFT_v1g242820.
GeneID	5513123.
KEGG	nve:NEMVE_v1g242820.
Phylogenomic databases
eggNOG	NOG308011.
HOGENOM	HOG000165463.
OMA	SEPRDYE.
Family and domain databases
InterPro	IPR005016. TMS_TDE. [Graphical view]
PANTHER	PTHR10383. PTHR10383. 1 hit.
Pfam	PF03348. Serinc. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SERIC_NEMVE

Accession

Primary (citable) accession number: A7S4N4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 2008
Last sequence update:	October 2, 2007
Last modified:	March 6, 2013
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)