ID   A7S2B4_NEMVE            Unreviewed;       690 AA.
AC   A7S2B4;
DT   02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT   02-OCT-2007, sequence version 1.
DT   27-MAR-2024, entry version 80.
DE   RecName: Full=acetate--CoA ligase {ECO:0000256|ARBA:ARBA00013275};
DE            EC=6.2.1.1 {ECO:0000256|ARBA:ARBA00013275};
GN   ORFNames=NEMVEDRAFT_v1g184779 {ECO:0000313|EMBL:EDO42084.1};
OS   Nematostella vectensis (Starlet sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Edwardsiidae; Nematostella.
OX   NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO42084.1, ECO:0000313|Proteomes:UP000001593};
RN   [1] {ECO:0000313|EMBL:EDO42084.1, ECO:0000313|Proteomes:UP000001593}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX   PubMed=17615350; DOI=10.1126/science.1139158;
RA   Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA   Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA   Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA   Technau U., Martindale M.Q., Rokhsar D.S.;
RT   "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT   genomic organization.";
RL   Science 317:86-94(2007).
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC       {ECO:0000256|ARBA:ARBA00006432}.
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DR   EMBL; DS469568; EDO42084.1; -; Genomic_DNA.
DR   RefSeq; XP_001634147.1; XM_001634097.1.
DR   AlphaFoldDB; A7S2B4; -.
DR   STRING; 45351.A7S2B4; -.
DR   EnsemblMetazoa; EDO42084; EDO42084; NEMVEDRAFT_v1g184779.
DR   KEGG; nve:5513930; -.
DR   eggNOG; KOG1175; Eukaryota.
DR   HOGENOM; CLU_000022_3_6_1; -.
DR   InParanoid; A7S2B4; -.
DR   OMA; MIGHYIT; -.
DR   OrthoDB; 144557at2759; -.
DR   PhylomeDB; A7S2B4; -.
DR   Proteomes; UP000001593; Unassembled WGS sequence.
DR   GO; GO:0003987; F:acetate-CoA ligase activity; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006085; P:acetyl-CoA biosynthetic process; IBA:GO_Central.
DR   CDD; cd05966; ACS; 1.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR032387; ACAS_N.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   PANTHER; PTHR24095; ACETYL-COENZYME A SYNTHETASE; 1.
DR   PANTHER; PTHR24095:SF244; ACETYL-COENZYME A SYNTHETASE; 1.
DR   Pfam; PF16177; ACAS_N; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001593}.
FT   DOMAIN          33..94
FT                   /note="Acetyl-coenzyme A synthetase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16177"
FT   DOMAIN          105..513
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
FT   DOMAIN          569..647
FT                   /note="AMP-binding enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13193"
SQ   SEQUENCE   690 AA;  77485 MW;  F4223D7B1225D6E6 CRC64;
     MAAASEHERE LEGWYNPPKE IQDEAHIASM DAYKARYKQS IEDPAGFWGE VASDFFWKVP
     PKSDHFLKYN FDLDNGSVDI KWMQGAKTNI CYNVLDRNVH DKGLGDTVAF YWEGNVPGDT
     KQITYGELLK QVCKFANVLE SKGVKKGDRV AIYMPMIMEL VIAMLACARL GAVHSIVFGG
     FSAESLAERI LDSTCKILIT ADASYRGLKM INLKEIADHA IIKCRERSFN VEACIVVRHL
     GPDKRVPTDP SSSPPPKRPC HQLQTSFDSS IDCWWHEVMA EASDEHDTVW VDAEDPLFML
     YTSGSTGKPK GVLHTHGGYM LYTALTFRYS FDYHPGEVYW CTADIGWITG HSYITYGPMA
     NGAISVLFEG TPFYPDCGRF WDIVDKYKVS KFYTAPTAIR SLMKFGKEIV TSHNLESLKV
     LGTVGEPINP EAWLWYYHVV GHNKCAIVDT YWQTETGGHV ITPLPGATRT RPGAATFPFF
     GVEPAIVDEK GNELEGPCEG FLVIKRPWPG MARTIYGNHK RFENVYFDKF RGYYTTGDGC
     KRDENGYYWV TGRTDDCMNV SGHLLSTAQI ESALVEHDAV SEAAVVSCPH KEKGEGIYCF
     ATLMENVELD EKLIRELKQK VRLKIGPFAS PDVIQSAPAL PKTRSGKIMR RVLRQVAKND
     RQTGDLSTIY DPAVVDSLFE ARPHVPFLPD
//