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Protein

Histone-lysine N-methyltransferase

Gene

v1g204976

Organism
Nematostella vectensis (Starlet sea anemone)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferasePROSITE-ProRule annotation, Transferase
LigandS-adenosyl-L-methioninePROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferasePROSITE-ProRule annotation (EC:2.1.1.43PROSITE-ProRule annotation)
Gene namesi
ORF Names:v1g204976Imported
OrganismiNematostella vectensis (Starlet sea anemone)Imported
Taxonomic identifieri45351 [NCBI]
Taxonomic lineageiEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaEdwardsiidaeNematostella
Proteomesi
  • UP000001593 Componenti: Unassembled WGS sequence

Interactioni

Protein-protein interaction databases

STRINGi45351.NEMVEDRAFT_v1g204976-PA.

Structurei

3D structure databases

ProteinModelPortaliA7S0P1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini114 – 229SETInterPro annotationAdd BLAST116

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2589. Eukaryota.
ENOG410XPH8. LUCA.
HOGENOMiHOG000007250.
InParanoidiA7S0P1.
KOiK11429.
OMAiNIACVEV.
OrthoDBiEOG091G0IUY.

Family and domain databases

InterProiView protein in InterPro
IPR025790. Hist-Lys_N-MTase_Suvar4-20.
IPR001214. SET_dom.
PfamiView protein in Pfam
PF00856. SET. 1 hit.
SMARTiView protein in SMART
SM00317. SET. 1 hit.
PROSITEiView protein in PROSITE
PS51570. SAM_MT43_SUVAR420_2. 1 hit.
PS50280. SET. 1 hit.

Sequencei

Sequence statusi: Complete.

A7S0P1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLNTPEGLK PGISRARQLA ESDDIASSLV VDSVLGFTTH KMAARFRPLK
60 70 80 90 100
IDATVVKRAL LRFLNDGDVD KAYDEIVFNA GDWGRCYFLN KSKNQIAAFK
110 120 130 140 150
DHMLRYIGIF HRDAGFKIHK CNRYSGESNG AKVVSTGHWA KGDKLPNLCG
160 170 180 190 200
CIAEMSEEEE KALLRAGEND FSIMFSTRKN LSQLWLGPAA YINHDCRPNC
210 220 230 240
KFVSTGRDTA CVKVLRDLEV GDEITCFYGE DFFGDDNCNC ECVTCER
Length:247
Mass (Da):27,657
Last modified:October 2, 2007 - v1
Checksum:iDB9106DADC7D26CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS469561 Genomic DNA. Translation: EDO42706.1.
RefSeqiXP_001634769.1. XM_001634719.1.
UniGeneiNve.1112.

Genome annotation databases

EnsemblMetazoaiEDO42706; EDO42706; NEMVEDRAFT_v1g204976.
GeneIDi5514661.
KEGGinve:NEMVE_v1g204976.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS469561 Genomic DNA. Translation: EDO42706.1.
RefSeqiXP_001634769.1. XM_001634719.1.
UniGeneiNve.1112.

3D structure databases

ProteinModelPortaliA7S0P1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi45351.NEMVEDRAFT_v1g204976-PA.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiEDO42706; EDO42706; NEMVEDRAFT_v1g204976.
GeneIDi5514661.
KEGGinve:NEMVE_v1g204976.

Phylogenomic databases

eggNOGiKOG2589. Eukaryota.
ENOG410XPH8. LUCA.
HOGENOMiHOG000007250.
InParanoidiA7S0P1.
KOiK11429.
OMAiNIACVEV.
OrthoDBiEOG091G0IUY.

Family and domain databases

InterProiView protein in InterPro
IPR025790. Hist-Lys_N-MTase_Suvar4-20.
IPR001214. SET_dom.
PfamiView protein in Pfam
PF00856. SET. 1 hit.
SMARTiView protein in SMART
SM00317. SET. 1 hit.
PROSITEiView protein in PROSITE
PS51570. SAM_MT43_SUVAR420_2. 1 hit.
PS50280. SET. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiA7S0P1_NEMVE
AccessioniPrimary (citable) accession number: A7S0P1
Entry historyiIntegrated into UniProtKB/TrEMBL: October 2, 2007
Last sequence update: October 2, 2007
Last modified: June 7, 2017
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.