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A7RT51 (A7RT51_NEMVE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specific RuleBase RU271113

EC=2.1.1.43 RuleBase RU271113
Alternative name(s):
Histone H3-K79 methyltransferase RuleBase RU271113
Gene names
ORF Names:v1g162356 EMBL EDO45397.1
OrganismNematostella vectensis (Starlet sea anemone) [Reference proteome]
Taxonomic identifier45351 [NCBI]
Taxonomic lineageEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaEdwardsiidaeNematostella

Protein attributes

Sequence length326 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. RuleBase RU271113

Subcellular location

Nucleus By similarity RuleBase RU271113.

Miscellaneous

In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones By similarity. RuleBase RU271113

Sequence similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family. RuleBase RU271113

Contains 1 DOT1 domain. RuleBase RU271113

Ontologies

Sequences

Sequence LengthMass (Da)Tools
A7RT51 [UniParc].

Last modified October 2, 2007. Version 1.
Checksum: 3343676EC944BDC6

FASTA32636,972
        10         20         30         40         50         60 
MAKELKLKSP AGGDSLVYTW PLNKVGEDGR DDASEIVEAI RWVCEDFPEL KLAVENYVLS 

        70         80         90        100        110        120 
SFDPESYESM SKLCERYNRA IDGILQLWKG RAPPPCIGIP PSTDLLRHII QTVYAKAVRD 

       130        140        150        160        170        180 
PEKLNSYEPF SPEVYGETSF DLVAQMIREV PMGREKTFID LGSGVGQVIL QVAASGNVKE 

       190        200        210        220        230        240 
CFGVEKADTP ARYAKEMDRC FRKWMHWFGK TYKPFTLVKG DFLDEKMRER LTTTDIIFVN 

       250        260        270        280        290        300 
NFAFGPSVDH QLKERFSTMK DGSMIISSKA FCPLNFRTTT RNLSDIGTIL HVTELKPLAR 

       310        320 
AVSWTGKSVS YYVHVVDRSL VSMFFL 

« Hide

References

[1]"Sea anemone genome reveals ancestral eumetazoan gene repertoire and genomic organization."
Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A., Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J., Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R., Technau U., Martindale M.Q., Rokhsar D.S.
Science 317:86-94(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CH2 X CH6.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS469536 Genomic DNA. Translation: EDO45397.1.
RefSeqXP_001637460.1. XM_001637410.1.
UniGeneNve.7900.

3D structure databases

ProteinModelPortalA7RT51.
SMRA7RT51. Positions 4-325.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING45351.JGI162356.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaNEMVEDRAFT_v1g162356-RA; NEMVEDRAFT_v1g162356-PA; NEMVEDRAFT_v1g162356.
GeneID5517386.
KEGGnve:NEMVE_v1g162356.

Phylogenomic databases

eggNOGNOG294902.
HOGENOMHOG000213803.
KOK11427.
OMAHKINQRT.
OrthoDBEOG7W6WJV.

Family and domain databases

InterProIPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
[Graphical view]
PfamPF08123. DOT1. 1 hit.
[Graphical view]
PROSITEPS51569. DOT1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA7RT51_NEMVE
AccessionPrimary (citable) accession number: A7RT51
Entry history
Integrated into UniProtKB/TrEMBL: October 2, 2007
Last sequence update: October 2, 2007
Last modified: April 16, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)