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Protein

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene

v1g162356

Organism
Nematostella vectensis (Starlet sea anemone)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

GO - Molecular functioni

  1. histone methyltransferase activity (H3-K79 specific) Source: InterPro

GO - Biological processi

  1. regulation of cell cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Alternative name(s):
Histone H3-K79 methyltransferaseUniRule annotation
Gene namesi
ORF Names:v1g162356Imported
OrganismiNematostella vectensis (Starlet sea anemone)Imported
Taxonomic identifieri45351 [NCBI]
Taxonomic lineageiEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaEdwardsiidaeNematostella
ProteomesiUP000001593: Unassembled WGS sequence

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi45351.JGI162356.

Structurei

3D structure databases

ProteinModelPortaliA7RT51.
SMRiA7RT51. Positions 4-325.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.UniRule annotation
Contains 1 DOT1 domain.UniRule annotation

Phylogenomic databases

eggNOGiNOG294902.
HOGENOMiHOG000213803.
InParanoidiA7RT51.
KOiK11427.
OMAiHKINQRT.
OrthoDBiEOG7W6WJV.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR025789. DOT1_dom.
IPR013110. DOT1_dom_Pfam.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF08123. DOT1. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51569. DOT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7RT51-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKELKLKSP AGGDSLVYTW PLNKVGEDGR DDASEIVEAI RWVCEDFPEL
60 70 80 90 100
KLAVENYVLS SFDPESYESM SKLCERYNRA IDGILQLWKG RAPPPCIGIP
110 120 130 140 150
PSTDLLRHII QTVYAKAVRD PEKLNSYEPF SPEVYGETSF DLVAQMIREV
160 170 180 190 200
PMGREKTFID LGSGVGQVIL QVAASGNVKE CFGVEKADTP ARYAKEMDRC
210 220 230 240 250
FRKWMHWFGK TYKPFTLVKG DFLDEKMRER LTTTDIIFVN NFAFGPSVDH
260 270 280 290 300
QLKERFSTMK DGSMIISSKA FCPLNFRTTT RNLSDIGTIL HVTELKPLAR
310 320
AVSWTGKSVS YYVHVVDRSL VSMFFL
Length:326
Mass (Da):36,972
Last modified:October 2, 2007 - v1
Checksum:i3343676EC944BDC6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS469536 Genomic DNA. Translation: EDO45397.1.
RefSeqiXP_001637460.1. XM_001637410.1.
UniGeneiNve.7900.

Genome annotation databases

EnsemblMetazoaiEDO45397; EDO45397; NEMVEDRAFT_v1g162356.
GeneIDi5517386.
KEGGinve:NEMVE_v1g162356.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS469536 Genomic DNA. Translation: EDO45397.1.
RefSeqiXP_001637460.1. XM_001637410.1.
UniGeneiNve.7900.

3D structure databases

ProteinModelPortaliA7RT51.
SMRiA7RT51. Positions 4-325.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi45351.JGI162356.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiEDO45397; EDO45397; NEMVEDRAFT_v1g162356.
GeneIDi5517386.
KEGGinve:NEMVE_v1g162356.

Phylogenomic databases

eggNOGiNOG294902.
HOGENOMiHOG000213803.
InParanoidiA7RT51.
KOiK11427.
OMAiHKINQRT.
OrthoDBiEOG7W6WJV.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR025789. DOT1_dom.
IPR013110. DOT1_dom_Pfam.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF08123. DOT1. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51569. DOT1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CH2 X CH6Imported.

Entry informationi

Entry nameiA7RT51_NEMVE
AccessioniPrimary (citable) accession number: A7RT51
Entry historyi
Integrated into UniProtKB/TrEMBL: October 2, 2007
Last sequence update: October 2, 2007
Last modified: March 4, 2015
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.