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A7RT51

- A7RT51_NEMVE

UniProt

A7RT51 - A7RT51_NEMVE

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Protein

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene
v1g162356
Organism
Nematostella vectensis (Starlet sea anemone)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Alternative name(s):
Histone H3-K79 methyltransferase
Gene namesi
ORF Names:v1g162356Imported
OrganismiNematostella vectensis (Starlet sea anemone)
Taxonomic identifieri45351 [NCBI]
Taxonomic lineageiEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaEdwardsiidaeNematostella
ProteomesiUP000001593: Unassembled WGS sequence

Subcellular locationi

Nucleus By similarity UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi45351.JGI162356.

Structurei

3D structure databases

ProteinModelPortaliA7RT51.
SMRiA7RT51. Positions 4-325.

Family & Domainsi

Sequence similaritiesi

Contains 1 DOT1 domain.UniRule annotation

Phylogenomic databases

eggNOGiNOG294902.
HOGENOMiHOG000213803.
KOiK11427.
OMAiHKINQRT.
OrthoDBiEOG7W6WJV.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF08123. DOT1. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51569. DOT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7RT51-1 [UniParc]FASTAAdd to Basket

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MAKELKLKSP AGGDSLVYTW PLNKVGEDGR DDASEIVEAI RWVCEDFPEL    50
KLAVENYVLS SFDPESYESM SKLCERYNRA IDGILQLWKG RAPPPCIGIP 100
PSTDLLRHII QTVYAKAVRD PEKLNSYEPF SPEVYGETSF DLVAQMIREV 150
PMGREKTFID LGSGVGQVIL QVAASGNVKE CFGVEKADTP ARYAKEMDRC 200
FRKWMHWFGK TYKPFTLVKG DFLDEKMRER LTTTDIIFVN NFAFGPSVDH 250
QLKERFSTMK DGSMIISSKA FCPLNFRTTT RNLSDIGTIL HVTELKPLAR 300
AVSWTGKSVS YYVHVVDRSL VSMFFL 326
Length:326
Mass (Da):36,972
Last modified:October 2, 2007 - v1
Checksum:i3343676EC944BDC6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS469536 Genomic DNA. Translation: EDO45397.1.
RefSeqiXP_001637460.1. XM_001637410.1.
UniGeneiNve.7900.

Genome annotation databases

EnsemblMetazoaiEDO45397; EDO45397; NEMVEDRAFT_v1g162356.
GeneIDi5517386.
KEGGinve:NEMVE_v1g162356.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS469536 Genomic DNA. Translation: EDO45397.1 .
RefSeqi XP_001637460.1. XM_001637410.1.
UniGenei Nve.7900.

3D structure databases

ProteinModelPortali A7RT51.
SMRi A7RT51. Positions 4-325.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 45351.JGI162356.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai EDO45397 ; EDO45397 ; NEMVEDRAFT_v1g162356 .
GeneIDi 5517386.
KEGGi nve:NEMVE_v1g162356.

Phylogenomic databases

eggNOGi NOG294902.
HOGENOMi HOG000213803.
KOi K11427.
OMAi HKINQRT.
OrthoDBi EOG7W6WJV.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF08123. DOT1. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51569. DOT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CH2 X CH6.

Entry informationi

Entry nameiA7RT51_NEMVE
AccessioniPrimary (citable) accession number: A7RT51
Entry historyi
Integrated into UniProtKB/TrEMBL: October 2, 2007
Last sequence update: October 2, 2007
Last modified: June 11, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones By similarity.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3