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A7RT51

- A7RT51_NEMVE

UniProt

A7RT51 - A7RT51_NEMVE

Protein

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene

v1g162356

Organism
Nematostella vectensis (Starlet sea anemone)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 1 (02 Oct 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

    GO - Molecular functioni

    1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

    Keywords - Ligandi

    S-adenosyl-L-methionineUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
    Alternative name(s):
    Histone H3-K79 methyltransferaseUniRule annotation
    Gene namesi
    ORF Names:v1g162356Imported
    OrganismiNematostella vectensis (Starlet sea anemone)Imported
    Taxonomic identifieri45351 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaEdwardsiidaeNematostella
    ProteomesiUP000001593: Unassembled WGS sequence

    Subcellular locationi

    Nucleus UniRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    NucleusUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi45351.JGI162356.

    Structurei

    3D structure databases

    ProteinModelPortaliA7RT51.
    SMRiA7RT51. Positions 4-325.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.UniRule annotation
    Contains 1 DOT1 domain.UniRule annotation

    Phylogenomic databases

    eggNOGiNOG294902.
    HOGENOMiHOG000213803.
    KOiK11427.
    OMAiHKINQRT.
    OrthoDBiEOG7W6WJV.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR013110. DOT1.
    IPR025789. Histone_H3-K79_MeTrfase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF08123. DOT1. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51569. DOT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A7RT51-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKELKLKSP AGGDSLVYTW PLNKVGEDGR DDASEIVEAI RWVCEDFPEL    50
    KLAVENYVLS SFDPESYESM SKLCERYNRA IDGILQLWKG RAPPPCIGIP 100
    PSTDLLRHII QTVYAKAVRD PEKLNSYEPF SPEVYGETSF DLVAQMIREV 150
    PMGREKTFID LGSGVGQVIL QVAASGNVKE CFGVEKADTP ARYAKEMDRC 200
    FRKWMHWFGK TYKPFTLVKG DFLDEKMRER LTTTDIIFVN NFAFGPSVDH 250
    QLKERFSTMK DGSMIISSKA FCPLNFRTTT RNLSDIGTIL HVTELKPLAR 300
    AVSWTGKSVS YYVHVVDRSL VSMFFL 326
    Length:326
    Mass (Da):36,972
    Last modified:October 2, 2007 - v1
    Checksum:i3343676EC944BDC6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS469536 Genomic DNA. Translation: EDO45397.1.
    RefSeqiXP_001637460.1. XM_001637410.1.
    UniGeneiNve.7900.

    Genome annotation databases

    EnsemblMetazoaiEDO45397; EDO45397; NEMVEDRAFT_v1g162356.
    GeneIDi5517386.
    KEGGinve:NEMVE_v1g162356.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS469536 Genomic DNA. Translation: EDO45397.1 .
    RefSeqi XP_001637460.1. XM_001637410.1.
    UniGenei Nve.7900.

    3D structure databases

    ProteinModelPortali A7RT51.
    SMRi A7RT51. Positions 4-325.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 45351.JGI162356.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai EDO45397 ; EDO45397 ; NEMVEDRAFT_v1g162356 .
    GeneIDi 5517386.
    KEGGi nve:NEMVE_v1g162356.

    Phylogenomic databases

    eggNOGi NOG294902.
    HOGENOMi HOG000213803.
    KOi K11427.
    OMAi HKINQRT.
    OrthoDBi EOG7W6WJV.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR013110. DOT1.
    IPR025789. Histone_H3-K79_MeTrfase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF08123. DOT1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51569. DOT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CH2 X CH6Imported.

    Entry informationi

    Entry nameiA7RT51_NEMVE
    AccessioniPrimary (citable) accession number: A7RT51
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 2, 2007
    Last sequence update: October 2, 2007
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Miscellaneous

    In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3