ID   A7RLT1_NEMVE            Unreviewed;       614 AA.
AC   A7RLT1;
DT   02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT   02-OCT-2007, sequence version 1.
DT   27-MAR-2024, entry version 85.
DE   RecName: Full=P/Homo B domain-containing protein {ECO:0000259|PROSITE:PS51829};
GN   ORFNames=NEMVEDRAFT_v1g160244 {ECO:0000313|EMBL:EDO47748.1};
OS   Nematostella vectensis (Starlet sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Edwardsiidae; Nematostella.
OX   NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO47748.1, ECO:0000313|Proteomes:UP000001593};
RN   [1] {ECO:0000313|EMBL:EDO47748.1, ECO:0000313|Proteomes:UP000001593}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX   PubMed=17615350; DOI=10.1126/science.1139158;
RA   Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA   Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA   Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA   Technau U., Martindale M.Q., Rokhsar D.S.;
RT   "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT   genomic organization.";
RL   Science 317:86-94(2007).
CC   -!- SIMILARITY: Belongs to the peptidase S8 family. Furin subfamily.
CC       {ECO:0000256|ARBA:ARBA00005325}.
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DR   EMBL; DS469518; EDO47748.1; -; Genomic_DNA.
DR   RefSeq; XP_001639811.1; XM_001639761.1.
DR   AlphaFoldDB; A7RLT1; -.
DR   STRING; 45351.A7RLT1; -.
DR   EnsemblMetazoa; EDO47748; EDO47748; NEMVEDRAFT_v1g160244.
DR   GeneID; 5519937; -.
DR   KEGG; nve:5519937; -.
DR   eggNOG; KOG3525; Eukaryota.
DR   HOGENOM; CLU_002976_4_1_1; -.
DR   InParanoid; A7RLT1; -.
DR   OMA; VWQKGFT; -.
DR   OrthoDB; 5474719at2759; -.
DR   PhylomeDB; A7RLT1; -.
DR   Proteomes; UP000001593; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IBA:GO_Central.
DR   GO; GO:0016485; P:protein processing; IBA:GO_Central.
DR   CDD; cd04059; Peptidases_S8_Protein_convertases_Kexins_Furin-like; 1.
DR   Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR   Gene3D; 3.30.70.850; Peptidase S8, pro-domain; 1.
DR   Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR034182; Kexin/furin.
DR   InterPro; IPR002884; P_dom.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR   InterPro; IPR022398; Peptidase_S8_His-AS.
DR   InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR   InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR   InterPro; IPR032815; S8_pro-domain.
DR   InterPro; IPR038466; S8_pro-domain_sf.
DR   PANTHER; PTHR42884:SF14; NEUROENDOCRINE CONVERTASE 1; 1.
DR   PANTHER; PTHR42884; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED; 1.
DR   Pfam; PF01483; P_proprotein; 1.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   Pfam; PF16470; S8_pro-domain; 1.
DR   PRINTS; PR00723; SUBTILISIN.
DR   SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR   SUPFAM; SSF54897; Protease propeptides/inhibitors; 1.
DR   SUPFAM; SSF52743; Subtilisin-like; 1.
DR   PROSITE; PS51829; P_HOMO_B; 1.
DR   PROSITE; PS51892; SUBTILASE; 1.
DR   PROSITE; PS00136; SUBTILASE_ASP; 1.
DR   PROSITE; PS00137; SUBTILASE_HIS; 1.
DR   PROSITE; PS00138; SUBTILASE_SER; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU01240};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW   ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000001593};
KW   Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW   ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..31
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           32..614
FT                   /note="P/Homo B domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002711375"
FT   DOMAIN          472..608
FT                   /note="P/Homo B"
FT                   /evidence="ECO:0000259|PROSITE:PS51829"
FT   ACT_SITE        179
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        220
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        394
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU01240"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:EDO47748.1"
SQ   SEQUENCE   614 AA;  68317 MW;  5B0670D4987BAFA0 CRC64;
     MFERVPPCRL LKSPIVFWIV LGVISWQGVS GADLSAEERV YTNGWAIHVN GGIEEAKEVA
     KAHGFEKVEP IGTLEGYYHL EHPSHPSRSR RSAEDRTDQL RQHRHVTWVE QQHEKVREKR
     GFYHDRMVAR GIVPRFKDPL WDAQWYLDDK RKDTDLDIHV IPVWKKGISG KGVVVTILDD
     GIEHNHTDLI KNYDPNASWD VNDGDNDPFP RYDPTNENKH GTRCAGEVAA EANNTKCGVG
     VAFNARIGGV RMLDGRVTDK VEAESLSLNP QYIDIYSASW GPSDDGATVE GPGTLATAAF
     LNGIQKGRGG LGSIFVWASG NGGRHGDSCN CDGYTDSIYT LSISSASDHG ESPWYSESCS
     STLATTFSSG AHGEKRIVTT DLHNTCTERH TGTSASAPLA AGIFALALEV NPKLTWRDMQ
     HIVVHTSNHL PLKHDQDWSK NGIDLMVNRK FGFGLLVAEK IVDMANPATY VTVPEKRFCR
     GQINQDAKVF KWDKPLTIQL PATGCSGTGD EIRYLEHVQL MVSLDYVRRG DLVIYLTSPM
     GTKSCLLSPR KEDSSNEGFS KWPFMTTHSW GEDPRGTWTL EIKDLGDNKA NHGTLREWQL
     ILHGTKDKPA HQQK
//