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A7RIT9

- 3HAO_NEMVE

UniProt

A7RIT9 - 3HAO_NEMVE

Protein

3-hydroxyanthranilate 3,4-dioxygenase

Gene

v1g178517

Organism
Nematostella vectensis (Starlet sea anemone)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (02 Oct 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.UniRule annotation

    Catalytic activityi

    3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde.UniRule annotation

    Cofactori

    Fe2+ ion.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei38 – 381DioxygenUniRule annotation
    Metal bindingi42 – 421Iron; catalyticUniRule annotation
    Metal bindingi48 – 481Iron; catalyticUniRule annotation
    Binding sitei48 – 481SubstrateUniRule annotation
    Metal bindingi86 – 861Iron; catalyticUniRule annotation
    Binding sitei90 – 901SubstrateUniRule annotation
    Binding sitei100 – 1001SubstrateUniRule annotation

    GO - Molecular functioni

    1. 3-hydroxyanthranilate 3,4-dioxygenase activity Source: UniProtKB-HAMAP
    2. ferrous iron binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
    2. anthranilate metabolic process Source: UniProtKB-HAMAP
    3. quinolinate biosynthetic process Source: UniProtKB-HAMAP
    4. tryptophan catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Dioxygenase, Oxidoreductase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00253; UER00330.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-hydroxyanthranilate 3,4-dioxygenaseUniRule annotation (EC:1.13.11.6UniRule annotation)
    Alternative name(s):
    3-hydroxyanthranilate oxygenaseUniRule annotation
    Short name:
    3-HAOUniRule annotation
    3-hydroxyanthranilic acid dioxygenaseUniRule annotation
    Short name:
    HADUniRule annotation
    Gene namesi
    ORF Names:v1g178517
    OrganismiNematostella vectensis (Starlet sea anemone)
    Taxonomic identifieri45351 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaEdwardsiidaeNematostella
    ProteomesiUP000001593: Unassembled WGS sequence

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2722723-hydroxyanthranilate 3,4-dioxygenasePRO_0000361973Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi45351.JGI178517.

    Structurei

    3D structure databases

    ProteinModelPortaliA7RIT9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 154154Domain A (catalytic)UniRule annotationAdd
    BLAST
    Regioni155 – 16915LinkerUniRule annotationAdd
    BLAST
    Regioni170 – 272103Domain BUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the 3-HAO family.UniRule annotation

    Phylogenomic databases

    eggNOGiNOG77058.
    HOGENOMiHOG000218448.
    KOiK00452.
    OMAiFYCKDLG.
    OrthoDBiEOG7FFMS4.

    Family and domain databases

    Gene3Di2.60.120.10. 2 hits.
    HAMAPiMF_00825. 3_HAO.
    InterProiIPR010329. 3hydroanth_dOase.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view]
    PANTHERiPTHR15497. PTHR15497. 1 hit.
    PfamiPF06052. 3-HAO. 1 hit.
    [Graphical view]
    SUPFAMiSSF51182. SSF51182. 2 hits.
    TIGRFAMsiTIGR03037. anthran_nbaC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A7RIT9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMEWIDENSS LFVPPVCNKL MYGEGQLKIM FVGGPNTRKD YHLEEGEELF    50
    FQVKGDMCLK VLEKGKPKDI IIKEGEMFLL PSRFNHSPQR FENTVGLVIE 100
    RERLPEEIDG LRYFCEDGVT VLWEKFFHCT DLTQIAPVIK EFFESEEHKT 150
    GKPSKESSCS INVDTETELM EPFPLKQWLK DNKDSYRSGS MAIFEKGEFK 200
    VHAHGSGEQE GHSQGEMWFW QLEGKATVNV DEITRELNKN DVLMITAGSD 250
    FRVKREEGSV GLSITVDSLA NK 272
    Length:272
    Mass (Da):31,200
    Last modified:October 2, 2007 - v1
    Checksum:iEEE73F11A02CC7B1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS469513 Genomic DNA. Translation: EDO48567.1.
    RefSeqiXP_001640630.1. XM_001640580.1.
    UniGeneiNve.6478.

    Genome annotation databases

    EnsemblMetazoaiEDO48567; EDO48567; NEMVEDRAFT_v1g178517.
    GeneIDi5520803.
    KEGGinve:NEMVE_v1g178517.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS469513 Genomic DNA. Translation: EDO48567.1 .
    RefSeqi XP_001640630.1. XM_001640580.1.
    UniGenei Nve.6478.

    3D structure databases

    ProteinModelPortali A7RIT9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 45351.JGI178517.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai EDO48567 ; EDO48567 ; NEMVEDRAFT_v1g178517 .
    GeneIDi 5520803.
    KEGGi nve:NEMVE_v1g178517.

    Phylogenomic databases

    eggNOGi NOG77058.
    HOGENOMi HOG000218448.
    KOi K00452.
    OMAi FYCKDLG.
    OrthoDBi EOG7FFMS4.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00330 .

    Family and domain databases

    Gene3Di 2.60.120.10. 2 hits.
    HAMAPi MF_00825. 3_HAO.
    InterProi IPR010329. 3hydroanth_dOase.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view ]
    PANTHERi PTHR15497. PTHR15497. 1 hit.
    Pfami PF06052. 3-HAO. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51182. SSF51182. 2 hits.
    TIGRFAMsi TIGR03037. anthran_nbaC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CH2 X CH6.

    Entry informationi

    Entry namei3HAO_NEMVE
    AccessioniPrimary (citable) accession number: A7RIT9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 10, 2009
    Last sequence update: October 2, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3