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Protein

3-hydroxyanthranilate 3,4-dioxygenase

Gene

v1g178517

Organism
Nematostella vectensis (Starlet sea anemone)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.UniRule annotation

Catalytic activityi

3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde.UniRule annotation

Cofactori

Fe2+UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes quinolinate from L-kynurenine.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Kynurenine 3-monooxygenase (KMO)
  2. Kynureninase (kynu)
  3. 3-hydroxyanthranilate 3,4-dioxygenase (v1g178517)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from L-kynurenine, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei38DioxygenUniRule annotation1
Metal bindingi42Iron; catalyticUniRule annotation1
Metal bindingi48Iron; catalyticUniRule annotation1
Binding sitei48SubstrateUniRule annotation1
Metal bindingi86Iron; catalyticUniRule annotation1
Binding sitei90SubstrateUniRule annotation1
Binding sitei100SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDioxygenase, Oxidoreductase
Biological processPyridine nucleotide biosynthesis
LigandIron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00253; UER00330

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyanthranilate 3,4-dioxygenaseUniRule annotation (EC:1.13.11.6UniRule annotation)
Alternative name(s):
3-hydroxyanthranilate oxygenaseUniRule annotation
Short name:
3-HAOUniRule annotation
3-hydroxyanthranilic acid dioxygenaseUniRule annotation
Short name:
HADUniRule annotation
Gene namesi
ORF Names:v1g178517
OrganismiNematostella vectensis (Starlet sea anemone)
Taxonomic identifieri45351 [NCBI]
Taxonomic lineageiEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaEdwardsiidaeNematostella
Proteomesi
  • UP000001593 Componenti: Unassembled WGS sequence

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003619731 – 2723-hydroxyanthranilate 3,4-dioxygenaseAdd BLAST272

Interactioni

Protein-protein interaction databases

STRINGi45351.NEMVEDRAFT_v1g178517-PA

Structurei

3D structure databases

ProteinModelPortaliA7RIT9
SMRiA7RIT9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 154Domain A (catalytic)UniRule annotationAdd BLAST154
Regioni155 – 169LinkerUniRule annotationAdd BLAST15
Regioni170 – 272Domain BUniRule annotationAdd BLAST103

Sequence similaritiesi

Belongs to the 3-HAO family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3995 Eukaryota
ENOG4111GH8 LUCA
HOGENOMiHOG000218448
InParanoidiA7RIT9
KOiK00452
OMAiCKDLGTQ
OrthoDBiEOG091G0IJ1

Family and domain databases

Gene3Di2.60.120.10, 1 hit
HAMAPiMF_00825 3_HAO, 1 hit
InterProiView protein in InterPro
IPR010329 3hydroanth_dOase
IPR014710 RmlC-like_jellyroll
IPR011051 RmlC_Cupin_sf
PANTHERiPTHR15497 PTHR15497, 1 hit
PfamiView protein in Pfam
PF06052 3-HAO, 1 hit
SUPFAMiSSF51182 SSF51182, 2 hits
TIGRFAMsiTIGR03037 anthran_nbaC, 1 hit

Sequencei

Sequence statusi: Complete.

A7RIT9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMEWIDENSS LFVPPVCNKL MYGEGQLKIM FVGGPNTRKD YHLEEGEELF
60 70 80 90 100
FQVKGDMCLK VLEKGKPKDI IIKEGEMFLL PSRFNHSPQR FENTVGLVIE
110 120 130 140 150
RERLPEEIDG LRYFCEDGVT VLWEKFFHCT DLTQIAPVIK EFFESEEHKT
160 170 180 190 200
GKPSKESSCS INVDTETELM EPFPLKQWLK DNKDSYRSGS MAIFEKGEFK
210 220 230 240 250
VHAHGSGEQE GHSQGEMWFW QLEGKATVNV DEITRELNKN DVLMITAGSD
260 270
FRVKREEGSV GLSITVDSLA NK
Length:272
Mass (Da):31,200
Last modified:October 2, 2007 - v1
Checksum:iEEE73F11A02CC7B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS469513 Genomic DNA Translation: EDO48567.1
RefSeqiXP_001640630.1, XM_001640580.1
UniGeneiNve.6478

Genome annotation databases

EnsemblMetazoaiEDO48567; EDO48567; NEMVEDRAFT_v1g178517
GeneIDi5520803
KEGGinve:NEMVE_v1g178517

Similar proteinsi

Entry informationi

Entry namei3HAO_NEMVE
AccessioniPrimary (citable) accession number: A7RIT9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: October 2, 2007
Last modified: March 28, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health