Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A7RIT9

- 3HAO_NEMVE

UniProt

A7RIT9 - 3HAO_NEMVE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

3-hydroxyanthranilate 3,4-dioxygenase

Gene

v1g178517

Organism
Nematostella vectensis (Starlet sea anemone)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.UniRule annotation

Catalytic activityi

3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde.UniRule annotation

Cofactori

Fe2+ ion.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei38 – 381DioxygenUniRule annotation
Metal bindingi42 – 421Iron; catalyticUniRule annotation
Metal bindingi48 – 481Iron; catalyticUniRule annotation
Binding sitei48 – 481SubstrateUniRule annotation
Metal bindingi86 – 861Iron; catalyticUniRule annotation
Binding sitei90 – 901SubstrateUniRule annotation
Binding sitei100 – 1001SubstrateUniRule annotation

GO - Molecular functioni

  1. 3-hydroxyanthranilate 3,4-dioxygenase activity Source: UniProtKB-HAMAP
  2. ferrous iron binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. anthranilate metabolic process Source: UniProtKB-HAMAP
  3. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  4. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00253; UER00330.

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyanthranilate 3,4-dioxygenaseUniRule annotation (EC:1.13.11.6UniRule annotation)
Alternative name(s):
3-hydroxyanthranilate oxygenaseUniRule annotation
Short name:
3-HAOUniRule annotation
3-hydroxyanthranilic acid dioxygenaseUniRule annotation
Short name:
HADUniRule annotation
Gene namesi
ORF Names:v1g178517
OrganismiNematostella vectensis (Starlet sea anemone)
Taxonomic identifieri45351 [NCBI]
Taxonomic lineageiEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaEdwardsiidaeNematostella
ProteomesiUP000001593: Unassembled WGS sequence

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2722723-hydroxyanthranilate 3,4-dioxygenasePRO_0000361973Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi45351.JGI178517.

Structurei

3D structure databases

ProteinModelPortaliA7RIT9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 154154Domain A (catalytic)UniRule annotationAdd
BLAST
Regioni155 – 16915LinkerUniRule annotationAdd
BLAST
Regioni170 – 272103Domain BUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the 3-HAO family.UniRule annotation

Phylogenomic databases

eggNOGiNOG77058.
HOGENOMiHOG000218448.
InParanoidiA7RIT9.
KOiK00452.
OMAiFYCKDLG.
OrthoDBiEOG7FFMS4.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
HAMAPiMF_00825. 3_HAO.
InterProiIPR010329. 3hydroanth_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR15497. PTHR15497. 1 hit.
PfamiPF06052. 3-HAO. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 2 hits.
TIGRFAMsiTIGR03037. anthran_nbaC. 1 hit.

Sequencei

Sequence statusi: Complete.

A7RIT9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMEWIDENSS LFVPPVCNKL MYGEGQLKIM FVGGPNTRKD YHLEEGEELF
60 70 80 90 100
FQVKGDMCLK VLEKGKPKDI IIKEGEMFLL PSRFNHSPQR FENTVGLVIE
110 120 130 140 150
RERLPEEIDG LRYFCEDGVT VLWEKFFHCT DLTQIAPVIK EFFESEEHKT
160 170 180 190 200
GKPSKESSCS INVDTETELM EPFPLKQWLK DNKDSYRSGS MAIFEKGEFK
210 220 230 240 250
VHAHGSGEQE GHSQGEMWFW QLEGKATVNV DEITRELNKN DVLMITAGSD
260 270
FRVKREEGSV GLSITVDSLA NK
Length:272
Mass (Da):31,200
Last modified:October 2, 2007 - v1
Checksum:iEEE73F11A02CC7B1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS469513 Genomic DNA. Translation: EDO48567.1.
RefSeqiXP_001640630.1. XM_001640580.1.
UniGeneiNve.6478.

Genome annotation databases

EnsemblMetazoaiEDO48567; EDO48567; NEMVEDRAFT_v1g178517.
GeneIDi5520803.
KEGGinve:NEMVE_v1g178517.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS469513 Genomic DNA. Translation: EDO48567.1 .
RefSeqi XP_001640630.1. XM_001640580.1.
UniGenei Nve.6478.

3D structure databases

ProteinModelPortali A7RIT9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 45351.JGI178517.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai EDO48567 ; EDO48567 ; NEMVEDRAFT_v1g178517 .
GeneIDi 5520803.
KEGGi nve:NEMVE_v1g178517.

Phylogenomic databases

eggNOGi NOG77058.
HOGENOMi HOG000218448.
InParanoidi A7RIT9.
KOi K00452.
OMAi FYCKDLG.
OrthoDBi EOG7FFMS4.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00330 .

Family and domain databases

Gene3Di 2.60.120.10. 2 hits.
HAMAPi MF_00825. 3_HAO.
InterProi IPR010329. 3hydroanth_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR15497. PTHR15497. 1 hit.
Pfami PF06052. 3-HAO. 1 hit.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 2 hits.
TIGRFAMsi TIGR03037. anthran_nbaC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CH2 X CH6.

Entry informationi

Entry namei3HAO_NEMVE
AccessioniPrimary (citable) accession number: A7RIT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: October 2, 2007
Last modified: October 29, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3