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A7RIT9 (3HAO_NEMVE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-hydroxyanthranilate 3,4-dioxygenase

EC=1.13.11.6
Alternative name(s):
3-hydroxyanthranilate oxygenase
Short name=3-HAO
3-hydroxyanthranilic acid dioxygenase
Short name=HAD
Gene names
ORF Names:v1g178517
OrganismNematostella vectensis (Starlet sea anemone) [Reference proteome]
Taxonomic identifier45351 [NCBI]
Taxonomic lineageEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaEdwardsiidaeNematostella

Protein attributes

Sequence length272 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate By similarity. HAMAP-Rule MF_03019

Catalytic activity

3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde. HAMAP-Rule MF_03019

Cofactor

Fe2+ ion By similarity. HAMAP-Rule MF_03019

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3. HAMAP-Rule MF_03019

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_03019.

Sequence similarities

Belongs to the 3-HAO family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2722723-hydroxyanthranilate 3,4-dioxygenase HAMAP-Rule MF_03019
PRO_0000361973

Regions

Region1 – 154154Domain A (catalytic) By similarity
Region155 – 16915Linker By similarity
Region170 – 272103Domain B By similarity

Sites

Metal binding421Iron; catalytic By similarity
Metal binding481Iron; catalytic By similarity
Metal binding861Iron; catalytic By similarity
Binding site381Dioxygen By similarity
Binding site481Substrate By similarity
Binding site901Substrate By similarity
Binding site1001Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
A7RIT9 [UniParc].

Last modified October 2, 2007. Version 1.
Checksum: EEE73F11A02CC7B1

FASTA27231,200
        10         20         30         40         50         60 
MMEWIDENSS LFVPPVCNKL MYGEGQLKIM FVGGPNTRKD YHLEEGEELF FQVKGDMCLK 

        70         80         90        100        110        120 
VLEKGKPKDI IIKEGEMFLL PSRFNHSPQR FENTVGLVIE RERLPEEIDG LRYFCEDGVT 

       130        140        150        160        170        180 
VLWEKFFHCT DLTQIAPVIK EFFESEEHKT GKPSKESSCS INVDTETELM EPFPLKQWLK 

       190        200        210        220        230        240 
DNKDSYRSGS MAIFEKGEFK VHAHGSGEQE GHSQGEMWFW QLEGKATVNV DEITRELNKN 

       250        260        270 
DVLMITAGSD FRVKREEGSV GLSITVDSLA NK 

« Hide

References

[1]"Sea anemone genome reveals ancestral eumetazoan gene repertoire and genomic organization."
Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A., Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J., Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R., Technau U., Martindale M.Q., Rokhsar D.S.
Science 317:86-94(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CH2 X CH6.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS469513 Genomic DNA. Translation: EDO48567.1.
RefSeqXP_001640630.1. XM_001640580.1.
UniGeneNve.6478.

3D structure databases

ProteinModelPortalA7RIT9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING45351.JGI178517.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaEDO48567; EDO48567; NEMVEDRAFT_v1g178517.
GeneID5520803.
KEGGnve:NEMVE_v1g178517.

Phylogenomic databases

eggNOGNOG77058.
HOGENOMHOG000218448.
KOK00452.
OMAFYCKDLG.
OrthoDBEOG7FFMS4.

Enzyme and pathway databases

UniPathwayUPA00253; UER00330.

Family and domain databases

Gene3D2.60.120.10. 2 hits.
HAMAPMF_00825. 3_HAO.
InterProIPR010329. 3hydroanth_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERPTHR15497. PTHR15497. 1 hit.
PfamPF06052. 3-HAO. 1 hit.
[Graphical view]
SUPFAMSSF51182. SSF51182. 2 hits.
TIGRFAMsTIGR03037. anthran_nbaC. 1 hit.
ProtoNetSearch...

Entry information

Entry name3HAO_NEMVE
AccessionPrimary (citable) accession number: A7RIT9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: October 2, 2007
Last modified: June 11, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways