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A7RIT9

- 3HAO_NEMVE

UniProt

A7RIT9 - 3HAO_NEMVE

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Protein

3-hydroxyanthranilate 3,4-dioxygenase

Gene
v1g178517
Organism
Nematostella vectensis (Starlet sea anemone)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate By similarity.UniRule annotation

Catalytic activityi

3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde.UniRule annotation

Cofactori

Fe2+ ion By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei38 – 381Dioxygen By similarity
Metal bindingi42 – 421Iron; catalytic By similarity
Metal bindingi48 – 481Iron; catalytic By similarity
Binding sitei48 – 481Substrate By similarity
Metal bindingi86 – 861Iron; catalytic By similarity
Binding sitei90 – 901Substrate By similarity
Binding sitei100 – 1001Substrate By similarity

GO - Molecular functioni

  1. 3-hydroxyanthranilate 3,4-dioxygenase activity Source: UniProtKB-HAMAP
  2. ferrous iron binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. anthranilate metabolic process Source: UniProtKB-HAMAP
  3. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  4. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00253; UER00330.

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyanthranilate 3,4-dioxygenase (EC:1.13.11.6)
Alternative name(s):
3-hydroxyanthranilate oxygenase
Short name:
3-HAO
3-hydroxyanthranilic acid dioxygenase
Short name:
HAD
Gene namesi
ORF Names:v1g178517
OrganismiNematostella vectensis (Starlet sea anemone)
Taxonomic identifieri45351 [NCBI]
Taxonomic lineageiEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaEdwardsiidaeNematostella
ProteomesiUP000001593: Unassembled WGS sequence

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2722723-hydroxyanthranilate 3,4-dioxygenaseUniRule annotationPRO_0000361973Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi45351.JGI178517.

Structurei

3D structure databases

ProteinModelPortaliA7RIT9.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 154154Domain A (catalytic) By similarityAdd
BLAST
Regioni155 – 16915Linker By similarityAdd
BLAST
Regioni170 – 272103Domain B By similarityAdd
BLAST

Sequence similaritiesi

Belongs to the 3-HAO family.

Phylogenomic databases

eggNOGiNOG77058.
HOGENOMiHOG000218448.
KOiK00452.
OMAiFYCKDLG.
OrthoDBiEOG7FFMS4.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
HAMAPiMF_00825. 3_HAO.
InterProiIPR010329. 3hydroanth_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR15497. PTHR15497. 1 hit.
PfamiPF06052. 3-HAO. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 2 hits.
TIGRFAMsiTIGR03037. anthran_nbaC. 1 hit.

Sequencei

Sequence statusi: Complete.

A7RIT9-1 [UniParc]FASTAAdd to Basket

« Hide

MMEWIDENSS LFVPPVCNKL MYGEGQLKIM FVGGPNTRKD YHLEEGEELF    50
FQVKGDMCLK VLEKGKPKDI IIKEGEMFLL PSRFNHSPQR FENTVGLVIE 100
RERLPEEIDG LRYFCEDGVT VLWEKFFHCT DLTQIAPVIK EFFESEEHKT 150
GKPSKESSCS INVDTETELM EPFPLKQWLK DNKDSYRSGS MAIFEKGEFK 200
VHAHGSGEQE GHSQGEMWFW QLEGKATVNV DEITRELNKN DVLMITAGSD 250
FRVKREEGSV GLSITVDSLA NK 272
Length:272
Mass (Da):31,200
Last modified:October 2, 2007 - v1
Checksum:iEEE73F11A02CC7B1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS469513 Genomic DNA. Translation: EDO48567.1.
RefSeqiXP_001640630.1. XM_001640580.1.
UniGeneiNve.6478.

Genome annotation databases

EnsemblMetazoaiEDO48567; EDO48567; NEMVEDRAFT_v1g178517.
GeneIDi5520803.
KEGGinve:NEMVE_v1g178517.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS469513 Genomic DNA. Translation: EDO48567.1 .
RefSeqi XP_001640630.1. XM_001640580.1.
UniGenei Nve.6478.

3D structure databases

ProteinModelPortali A7RIT9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 45351.JGI178517.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai EDO48567 ; EDO48567 ; NEMVEDRAFT_v1g178517 .
GeneIDi 5520803.
KEGGi nve:NEMVE_v1g178517.

Phylogenomic databases

eggNOGi NOG77058.
HOGENOMi HOG000218448.
KOi K00452.
OMAi FYCKDLG.
OrthoDBi EOG7FFMS4.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00330 .

Family and domain databases

Gene3Di 2.60.120.10. 2 hits.
HAMAPi MF_00825. 3_HAO.
InterProi IPR010329. 3hydroanth_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR15497. PTHR15497. 1 hit.
Pfami PF06052. 3-HAO. 1 hit.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 2 hits.
TIGRFAMsi TIGR03037. anthran_nbaC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CH2 X CH6.

Entry informationi

Entry namei3HAO_NEMVE
AccessioniPrimary (citable) accession number: A7RIT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: October 2, 2007
Last modified: June 11, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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