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Protein

Eukaryotic translation initiation factor 6

Gene

EIF6

Organism
Nematostella vectensis (Starlet sea anemone)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.UniRule annotation

GO - Molecular functioni

  1. ribosomal large subunit binding Source: UniProtKB-HAMAP
  2. ribosome binding Source: InterPro
  3. translation initiation factor activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. mature ribosome assembly Source: UniProtKB-HAMAP
  2. ribosomal large subunit biogenesis Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Initiation factorUniRule annotation

Keywords - Biological processi

Protein biosynthesis, Ribosome biogenesisUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 6UniRule annotation
Short name:
eIF-6UniRule annotation
Gene namesi
Name:EIF6UniRule annotation
ORF Names:v1g177965Imported
OrganismiNematostella vectensis (Starlet sea anemone)Imported
Taxonomic identifieri45351 [NCBI]
Taxonomic lineageiEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaEdwardsiidaeNematostella
ProteomesiUP000001593 Componenti: Unassembled WGS sequence

Subcellular locationi

Cytoplasm UniRule annotation. Nucleusnucleolus UniRule annotation
Note: Shuttles between cytoplasm and nucleus/nucleolus.UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleolus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation

Interactioni

Subunit structurei

Monomer. Associates with the 60S ribosomal subunit.UniRule annotation

Protein-protein interaction databases

STRINGi45351.JGI177965.

Structurei

3D structure databases

ProteinModelPortaliA7RHF7.
SMRiA7RHF7. Positions 1-224.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-6 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1976.
HOGENOMiHOG000230605.
InParanoidiA7RHF7.
KOiK03264.
OMAiNDWCAFT.
OrthoDBiEOG7V4B05.

Family and domain databases

HAMAPiMF_00032. eIF_6.
InterProiIPR002769. eIF6.
[Graphical view]
PANTHERiPTHR10784. PTHR10784. 1 hit.
PfamiPF01912. eIF-6. 1 hit.
[Graphical view]
PIRSFiPIRSF006413. IF-6. 1 hit.
SMARTiSM00654. eIF6. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00323. eIF-6. 1 hit.

Sequencei

Sequence statusi: Complete.

A7RHF7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVRAQFENS NEVGVFSKLT NAYCLVAIGA TENFYSVFES ELSDVIPVVR
60 70 80 90 100
TSIAGCRIIG RLCVGNRHGL LVPSTTTDQE LQYIRNALPD QVKIQRVEER
110 120 130 140 150
LSALGNVIAC NDYVALTHLD LDMETQEILA DVLKVEVFRQ SLASNVLVGS
160 170 180 190 200
YCALSNQGGL VHPRTSIEDQ DELSSLLQVP LVAGTVNRGS DVIGAGLVVN
210 220 230
DWSAFCGSDT TSTELSVIES VFKIGDAQQS SIGDNH
Length:236
Mass (Da):25,450
Last modified:October 2, 2007 - v1
Checksum:i3114A0397C8F370F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS469510 Genomic DNA. Translation: EDO49340.1.
RefSeqiXP_001641403.1. XM_001641353.1.
UniGeneiNve.7378.

Genome annotation databases

EnsemblMetazoaiEDO49340; EDO49340; NEMVEDRAFT_v1g177965.
GeneIDi5521502.
KEGGinve:NEMVE_v1g177965.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS469510 Genomic DNA. Translation: EDO49340.1.
RefSeqiXP_001641403.1. XM_001641353.1.
UniGeneiNve.7378.

3D structure databases

ProteinModelPortaliA7RHF7.
SMRiA7RHF7. Positions 1-224.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi45351.JGI177965.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiEDO49340; EDO49340; NEMVEDRAFT_v1g177965.
GeneIDi5521502.
KEGGinve:NEMVE_v1g177965.

Phylogenomic databases

eggNOGiCOG1976.
HOGENOMiHOG000230605.
InParanoidiA7RHF7.
KOiK03264.
OMAiNDWCAFT.
OrthoDBiEOG7V4B05.

Family and domain databases

HAMAPiMF_00032. eIF_6.
InterProiIPR002769. eIF6.
[Graphical view]
PANTHERiPTHR10784. PTHR10784. 1 hit.
PfamiPF01912. eIF-6. 1 hit.
[Graphical view]
PIRSFiPIRSF006413. IF-6. 1 hit.
SMARTiSM00654. eIF6. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00323. eIF-6. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CH2 X CH6Imported.

Entry informationi

Entry nameiA7RHF7_NEMVE
AccessioniPrimary (citable) accession number: A7RHF7
Entry historyi
Integrated into UniProtKB/TrEMBL: October 2, 2007
Last sequence update: October 2, 2007
Last modified: January 7, 2015
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.