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Protein

Eukaryotic translation initiation factor 6

Gene

EIF6

Organism
Nematostella vectensis (Starlet sea anemone)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionInitiation factorUniRule annotation
Biological processProtein biosynthesis, Ribosome biogenesisUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 6UniRule annotation
Short name:
eIF-6UniRule annotation
Gene namesi
Name:EIF6UniRule annotation
ORF Names:v1g177965Imported
OrganismiNematostella vectensis (Starlet sea anemone)Imported
Taxonomic identifieri45351 [NCBI]
Taxonomic lineageiEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaEdwardsiidaeNematostella
Proteomesi
  • UP000001593 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation

Interactioni

Subunit structurei

Monomer. Associates with the 60S ribosomal subunit.UniRule annotation

Protein-protein interaction databases

STRINGi45351.NEMVEDRAFT_v1g177965-PA.

Structurei

3D structure databases

ProteinModelPortaliA7RHF7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-6 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3185. Eukaryota.
COG1976. LUCA.
HOGENOMiHOG000230605.
InParanoidiA7RHF7.
KOiK03264.
OMAiTAGNRHG.
OrthoDBiEOG091G0HYF.

Family and domain databases

CDDicd00527. IF6. 1 hit.
HAMAPiMF_00032. eIF_6. 1 hit.
InterProiView protein in InterPro
IPR002769. eIF6.
PANTHERiPTHR10784. PTHR10784. 1 hit.
PfamiView protein in Pfam
PF01912. eIF-6. 1 hit.
PIRSFiPIRSF006413. IF-6. 1 hit.
SMARTiView protein in SMART
SM00654. eIF6. 1 hit.
TIGRFAMsiTIGR00323. eIF-6. 1 hit.

Sequencei

Sequence statusi: Complete.

A7RHF7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVRAQFENS NEVGVFSKLT NAYCLVAIGA TENFYSVFES ELSDVIPVVR
60 70 80 90 100
TSIAGCRIIG RLCVGNRHGL LVPSTTTDQE LQYIRNALPD QVKIQRVEER
110 120 130 140 150
LSALGNVIAC NDYVALTHLD LDMETQEILA DVLKVEVFRQ SLASNVLVGS
160 170 180 190 200
YCALSNQGGL VHPRTSIEDQ DELSSLLQVP LVAGTVNRGS DVIGAGLVVN
210 220 230
DWSAFCGSDT TSTELSVIES VFKIGDAQQS SIGDNH
Length:236
Mass (Da):25,450
Last modified:October 2, 2007 - v1
Checksum:i3114A0397C8F370F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS469510 Genomic DNA. Translation: EDO49340.1.
RefSeqiXP_001641403.1. XM_001641353.1.
UniGeneiNve.7378.

Genome annotation databases

EnsemblMetazoaiEDO49340; EDO49340; NEMVEDRAFT_v1g177965.
GeneIDi5521502.
KEGGinve:NEMVE_v1g177965.

Similar proteinsi

Entry informationi

Entry nameiA7RHF7_NEMVE
AccessioniPrimary (citable) accession number: A7RHF7
Entry historyiIntegrated into UniProtKB/TrEMBL: October 2, 2007
Last sequence update: October 2, 2007
Last modified: September 27, 2017
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported