A7RFA3 (A7RFA3_NEMVE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Histone deacetylase PIRNR PIRNR037913
EC=3.5.1.98 PIRNR PIRNR037913

Gene names

ORF Names:

v1g79092

Organism

Nematostella vectensis (Starlet sea anemone)

Taxonomic identifier

45351 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Cnidaria › Anthozoa › Hexacorallia › Actiniaria › Edwardsiidae › Nematostella

Protein attributes

Sequence length	442 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone. PIRNR PIRNR037913
Subcellular location	Nucleus By similarity PIRNR PIRNR037913.
Sequence similarities	Belongs to the histone deacetylase family. HD Type 1 subfamily. PIRNR PIRNR037913

Ontologies

Keywords
Biological process	Transcription Transcription regulation PIRNR PIRNR037913
Cellular component	Nucleus PIRNR PIRNR037913
Molecular function	Chromatin regulator PIRNR PIRNR037913 Hydrolase PIRNR PIRNR037913 SAAS SAAS000286
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NAD-dependent histone deacetylase activity (H3-K14 specific) Inferred from electronic annotation. Source: EC NAD-dependent histone deacetylase activity (H3-K9 specific) Inferred from electronic annotation. Source: EC NAD-dependent histone deacetylase activity (H4-K16 specific) Inferred from electronic annotation. Source: EC histone deacetylase activity (H3-K16 specific) Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	442	1	EMBL EDO49920.1

Sequences

	Sequence		Length	Mass (Da)
	A7RFA3 [UniParc]. Last modified October 2, 2007. Version 1. Checksum: 8AE75683E0E5E008	FASTA	442	50,593
	10 20 30 40 50 60 MAYTSAGGKK KVCYYYDGDI GNYYYGQGHP MKPHRIRMTH NLLLNYGLYR KMEIYRPHKA 70 80 90 100 110 120 AMEEITRYHS DDYIKFLKSI RPDNMSDYTK QMQRFNVGED CPVFDGLYEF CQLSTGGSIA 130 140 150 160 170 180 GAVKLNKQHT DIAINWSGGL HHAKKSEASG FCYVNDIVLA ILELLKYHQR VLYIDIDIHH 190 200 210 220 230 240 GDGVEEAFYT TDRVMTVSFH KYGEYFPGTG DLRDIGAGRG KYYAVNFPLR DGIEDESYQQ 250 260 270 280 290 300 IFQPIITKVI EIYQPNAVVL QCGADSLAGD RLGCFNLSLK GHAKCVEFVK SFNLPLLILG 310 320 330 340 350 360 GGGYTIRNVA RCWTYETSVA LDSDIANELP YNDYFEYFGP DFKLHISPSN MTNQNTPDYL 370 380 390 400 410 420 DKIKQRLFEN LRMIPHAPGV QMQPIPEDAF PAESDNEDEE DPNQRISIRA SDKRIACEEE 430 440 FSDSEDEGEG RRDVRENRPH KR

References

[1]

"Sea anemone genome reveals ancestral eumetazoan gene repertoire and genomic organization." Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A., Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J., Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R., Technau U., Martindale M.Q., Rokhsar D.S. Science 317:86-94(2007) [PubMed: 17615350] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CH2 X CH6.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DS469507 Genomic DNA. Translation: EDO49920.1.
RefSeq	XP_001641983.1. XM_001641933.1.
UniGene	Nve.325.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A7RFA3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	NEMVEDRAFT_v1g79092-RA; NEMVEDRAFT_v1g79092-PA; NEMVEDRAFT_v1g79092.
GeneID	5522239.
KEGG	nve:NEMVE_v1g79092.
Phylogenomic databases
OMA	AYESIFV.
PhylomeDB	A7RFA3.
Family and domain databases
InterPro	IPR000286. His_deacetylse. IPR003084. His_deacetylse_1. IPR023801. His_deacetylse_dom. [Graphical view]
Gene3D	G3DSA:3.40.800.20. His_deacetylse. 1 hit.
KO	K06067.
PANTHER	PTHR10625. His_deacetylse. 1 hit.
Pfam	PF00850. Hist_deacetyl. 1 hit. [Graphical view]
PIRSF	PIRSF037913. His_deacetylse_1. 1 hit.
PRINTS	PR01270. HDASUPER. PR01271. HISDACETLASE.
ProtoNet	Search...

Entry information

Entry name

A7RFA3_NEMVE

Accession

Primary (citable) accession number: A7RFA3

Entry history

Integrated into UniProtKB/TrEMBL:	October 2, 2007
Last sequence update:	October 2, 2007
Last modified:	December 14, 2011
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)