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A7RDN6 (RNLS_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Renalase

EC=1.6.3.5
Alternative name(s):
Monoamine oxidase-C
Short name=MAO-C
Short name=mMAO-C
alpha-NAD(P)H oxidase/anomerase
Gene names
Name:Rnls
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length342 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the oxidation of the less abundant alpha-NAD(P)H isoform toform beta-NAD(P)+. The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis By similarity.

Catalytic activity

Alpha-NAD(P)H + O2 = beta-NAD(P)+ + H2O2.

Cofactor

FAD By similarity. UniProtKB Q5VYX0

Subcellular location

Secreted Ref.1.

Tissue specificity

Expressed predominantly in kidney and testis with lower levels in liver, heart and embryo and weak expression in brain and skeletal muscle. Ref.1

Sequence similarities

Belongs to the renalase family.

Sequence caution

The sequence AAH52355.2 differs from that shown. Reason: Erroneous termination at position 33. Translated as Trp.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 Ref.1 (identifier: A7RDN6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 Ref.2 (identifier: A7RDN6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     41-123: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 342325Renalase
PRO_0000376858

Regions

Region61 – 622FAD-binding By similarity

Sites

Binding site121FAD By similarity
Binding site421FAD By similarity

Natural variations

Alternative sequence41 – 12383Missing in isoform 2. Ref.2
VSP_053114

Experimental info

Sequence conflict311G → A in ABG82016. Ref.1
Sequence conflict311G → A in BAE41716. Ref.2
Sequence conflict361G → A in ABG82016. Ref.1
Sequence conflict361G → A in BAE41716. Ref.2
Sequence conflict1381K → E in BAE41716. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 16, 2009. Version 2.
Checksum: 0445A137C6E1F981

FASTA34237,597
        10         20         30         40         50         60 
MSRVLVVGAG LTGSLCAALL RKEITAPLYL GLWDKGGDIG GRMITASSPH NPRCTADLGA 

        70         80         90        100        110        120 
QYITCSPHYV KEHQNFYEEL LAHGILKPLT SPIEGMKGKE GDCNFVAPQG FSSVIKYYLK 

       130        140        150        160        170        180 
KSGAEVSLKH CVTQIHLKDN KWEVSTDTGS AEQFDLVILT MPAPQILELQ GDIVNLISER 

       190        200        210        220        230        240 
QREQLKSVSY SSRYALGLFY EVGMKIGVPW SCRYLSSHPC ICFISIDNKK RNIESSECGP 

       250        260        270        280        290        300 
SVVIQTTVPF GVQHLEASEA DVQKLMIQQL ETILPGLPQP VATICHKWTY SQVTSSVSDR 

       310        320        330        340 
PGQMTLHLKP FLVCGGDGFT HSNFNGCISS ALSVMKVLKR YI 

« Hide

Isoform 2 [UniParc].

Checksum: 5F3898120A31E513
Show »

FASTA25928,457

References

« Hide 'large scale' references
[1]"Identification, expression and tissue distribution of a renalase homologue from mouse."
Wang J., Qi S., Cheng W., Li L., Wang F., Li Y.-Z., Zhang S.-P.
Mol. Biol. Rep. 35:613-620(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Strain: Kunming.
Tissue: Kidney.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: NOD.
Tissue: Dendritic cell.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ788834 mRNA. Translation: ABG82016.1.
AK170321 mRNA. Translation: BAE41716.1.
BC052355 mRNA. Translation: AAH52355.2. Sequence problems.
RefSeqNP_001139814.2. NM_001146342.2.
NP_001161290.1. NM_001167818.1.
UniGeneMm.204591.

3D structure databases

ProteinModelPortalA7RDN6.
SMRA7RDN6. Positions 1-341.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteA7RDN6.

Proteomic databases

PaxDbA7RDN6.
PRIDEA7RDN6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000096114; ENSMUSP00000093825; ENSMUSG00000071573.
GeneID67795.
KEGGmmu:67795.
UCSCuc008hft.2. mouse. [A7RDN6-1]

Organism-specific databases

CTD55328.
MGIMGI:1915045. Rnls.

Phylogenomic databases

eggNOGNOG74071.
GeneTreeENSGT00390000016052.
HOGENOMHOG000007721.
InParanoidQ80W75.
KOK18208.
OrthoDBEOG747PJ6.
PhylomeDBA7RDN6.
TreeFamTF332799.

Gene expression databases

BgeeA7RDN6.
GenevestigatorA7RDN6.

Family and domain databases

InterProIPR002937. Amino_oxidase.
[Graphical view]
PfamPF01593. Amino_oxidase. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio325581.
PROA7RDN6.
SOURCESearch...

Entry information

Entry nameRNLS_MOUSE
AccessionPrimary (citable) accession number: A7RDN6
Secondary accession number(s): Q3TD88, Q80W75
Entry history
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: June 16, 2009
Last modified: July 9, 2014
This is version 49 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot