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A7RDN6

- RNLS_MOUSE

UniProt

A7RDN6 - RNLS_MOUSE

Protein

Renalase

Gene

Rnls

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 2 (16 Jun 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidation of the less abundant alpha-NAD(P)H isoform to form beta-NAD(P)+. The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis By similarity.By similarity

    Catalytic activityi

    Alpha-NAD(P)H + O2 = beta-NAD(P)+ + H2O2.

    Cofactori

    FAD.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei12 – 121FADBy similarity
    Binding sitei42 – 421FADBy similarity

    GO - Molecular functioni

    1. oxidoreductase activity Source: MGI

    GO - Biological processi

    1. cardiac left ventricle morphogenesis Source: MGI
    2. dopamine metabolic process Source: MGI
    3. epinephrine metabolic process Source: MGI
    4. heart contraction Source: MGI
    5. norepinephrine metabolic process Source: MGI
    6. phosphate ion homeostasis Source: MGI
    7. regulation of systemic arterial blood pressure Source: MGI
    8. response to epinephrine Source: Ensembl
    9. response to ischemia Source: Ensembl
    10. response to norepinephrine Source: MGI
    11. response to salt Source: Ensembl

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein, NAD, NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Renalase1 Publication (EC:1.6.3.5)
    Alternative name(s):
    Monoamine oxidase-C1 Publication
    Short name:
    MAO-C
    Short name:
    mMAO-C1 Publication
    alpha-NAD(P)H oxidase/anomerase
    Gene namesi
    Name:RnlsImported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:1915045. Rnls.

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. extracellular space Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 342325RenalaseSequence AnalysisPRO_0000376858Add
    BLAST

    Proteomic databases

    PaxDbiA7RDN6.
    PRIDEiA7RDN6.

    PTM databases

    PhosphoSiteiA7RDN6.

    Expressioni

    Tissue specificityi

    Expressed predominantly in kidney and testis with lower levels in liver, heart and embryo and weak expression in brain and skeletal muscle.1 Publication

    Gene expression databases

    BgeeiA7RDN6.
    GenevestigatoriA7RDN6.

    Structurei

    3D structure databases

    ProteinModelPortaliA7RDN6.
    SMRiA7RDN6. Positions 1-341.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni61 – 622FAD-bindingBy similarity

    Sequence similaritiesi

    Belongs to the renalase family.Sequence Analysis

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG74071.
    GeneTreeiENSGT00390000016052.
    HOGENOMiHOG000007721.
    InParanoidiQ80W75.
    KOiK18208.
    OrthoDBiEOG747PJ6.
    PhylomeDBiA7RDN6.
    TreeFamiTF332799.

    Family and domain databases

    InterProiIPR002937. Amino_oxidase.
    [Graphical view]
    PfamiPF01593. Amino_oxidase. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 11 Publication (identifier: A7RDN6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSRVLVVGAG LTGSLCAALL RKEITAPLYL GLWDKGGDIG GRMITASSPH    50
    NPRCTADLGA QYITCSPHYV KEHQNFYEEL LAHGILKPLT SPIEGMKGKE 100
    GDCNFVAPQG FSSVIKYYLK KSGAEVSLKH CVTQIHLKDN KWEVSTDTGS 150
    AEQFDLVILT MPAPQILELQ GDIVNLISER QREQLKSVSY SSRYALGLFY 200
    EVGMKIGVPW SCRYLSSHPC ICFISIDNKK RNIESSECGP SVVIQTTVPF 250
    GVQHLEASEA DVQKLMIQQL ETILPGLPQP VATICHKWTY SQVTSSVSDR 300
    PGQMTLHLKP FLVCGGDGFT HSNFNGCISS ALSVMKVLKR YI 342
    Length:342
    Mass (Da):37,597
    Last modified:June 16, 2009 - v2
    Checksum:i0445A137C6E1F981
    GO
    Isoform 21 Publication (identifier: A7RDN6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         41-123: Missing.

    Note: No experimental confirmation available.Curated

    Show »
    Length:259
    Mass (Da):28,457
    Checksum:i5F3898120A31E513
    GO

    Sequence cautioni

    The sequence AAH52355.2 differs from that shown. Reason: Erroneous termination at position 33. Translated as Trp.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti31 – 311G → A in ABG82016. (PubMed:17846919)Curated
    Sequence conflicti31 – 311G → A in BAE41716. (PubMed:16141072)Curated
    Sequence conflicti36 – 361G → A in ABG82016. (PubMed:17846919)Curated
    Sequence conflicti36 – 361G → A in BAE41716. (PubMed:16141072)Curated
    Sequence conflicti138 – 1381K → E in BAE41716. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei41 – 12383Missing in isoform 2. 1 PublicationVSP_053114Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ788834 mRNA. Translation: ABG82016.1.
    AK170321 mRNA. Translation: BAE41716.1.
    BC052355 mRNA. Translation: AAH52355.2. Sequence problems.
    RefSeqiNP_001139814.2. NM_001146342.2.
    NP_001161290.1. NM_001167818.1.
    UniGeneiMm.204591.

    Genome annotation databases

    EnsembliENSMUST00000096114; ENSMUSP00000093825; ENSMUSG00000071573.
    GeneIDi67795.
    KEGGimmu:67795.
    UCSCiuc008hft.2. mouse. [A7RDN6-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ788834 mRNA. Translation: ABG82016.1 .
    AK170321 mRNA. Translation: BAE41716.1 .
    BC052355 mRNA. Translation: AAH52355.2 . Sequence problems.
    RefSeqi NP_001139814.2. NM_001146342.2.
    NP_001161290.1. NM_001167818.1.
    UniGenei Mm.204591.

    3D structure databases

    ProteinModelPortali A7RDN6.
    SMRi A7RDN6. Positions 1-341.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei A7RDN6.

    Proteomic databases

    PaxDbi A7RDN6.
    PRIDEi A7RDN6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000096114 ; ENSMUSP00000093825 ; ENSMUSG00000071573 .
    GeneIDi 67795.
    KEGGi mmu:67795.
    UCSCi uc008hft.2. mouse. [A7RDN6-1 ]

    Organism-specific databases

    CTDi 55328.
    MGIi MGI:1915045. Rnls.

    Phylogenomic databases

    eggNOGi NOG74071.
    GeneTreei ENSGT00390000016052.
    HOGENOMi HOG000007721.
    InParanoidi Q80W75.
    KOi K18208.
    OrthoDBi EOG747PJ6.
    PhylomeDBi A7RDN6.
    TreeFami TF332799.

    Miscellaneous databases

    NextBioi 325581.
    PROi A7RDN6.
    SOURCEi Search...

    Gene expression databases

    Bgeei A7RDN6.
    Genevestigatori A7RDN6.

    Family and domain databases

    InterProi IPR002937. Amino_oxidase.
    [Graphical view ]
    Pfami PF01593. Amino_oxidase. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification, expression and tissue distribution of a renalase homologue from mouse."
      Wang J., Qi S., Cheng W., Li L., Wang F., Li Y.-Z., Zhang S.-P.
      Mol. Biol. Rep. 35:613-620(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Strain: KunmingImported.
      Tissue: KidneyImported.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: NODImported.
      Tissue: Dendritic cellImported.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: TestisImported.

    Entry informationi

    Entry nameiRNLS_MOUSE
    AccessioniPrimary (citable) accession number: A7RDN6
    Secondary accession number(s): Q3TD88, Q80W75
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 16, 2009
    Last sequence update: June 16, 2009
    Last modified: October 1, 2014
    This is version 50 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3