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A7NRF8

- THIM_ROSCS

UniProt

A7NRF8 - THIM_ROSCS

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Protein

Hydroxyethylthiazole kinase

Gene

thiM

Organism
Roseiflexus castenholzii (strain DSM 13941 / HLO8)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).UniRule annotation

Catalytic activityi

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

Cofactori

Magnesium.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei47 – 471Substrate; via amide nitrogenUniRule annotation
Binding sitei123 – 1231ATPUniRule annotation
Binding sitei169 – 1691ATPUniRule annotation
Binding sitei196 – 1961Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. thiamine biosynthetic process Source: UniProtKB-KW
  2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Thiamine biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRCAS383372:GH89-4177-MONOMER.
UniPathwayiUPA00060; UER00139.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyethylthiazole kinaseUniRule annotation (EC:2.7.1.50UniRule annotation)
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinaseUniRule annotation
Short name:
TH kinaseUniRule annotation
Short name:
Thz kinaseUniRule annotation
Gene namesi
Name:thiMUniRule annotation
Ordered Locus Names:Rcas_4122
OrganismiRoseiflexus castenholzii (strain DSM 13941 / HLO8)
Taxonomic identifieri383372 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesRoseiflexineaeRoseiflexaceaeRoseiflexus
ProteomesiUP000000263: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 270270Hydroxyethylthiazole kinasePRO_0000336567Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi383372.Rcas_4122.

Structurei

3D structure databases

ProteinModelPortaliA7NRF8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Thz kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2145.
HOGENOMiHOG000114352.
KOiK00878.
OMAiQTFTANV.
OrthoDBiEOG628F8M.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
HAMAPiMF_00228. Thz_kinase.
InterProiIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF02110. HK. 1 hit.
[Graphical view]
PIRSFiPIRSF000513. Thz_kinase. 1 hit.
PRINTSiPR01099. HYETHTZKNASE.
SUPFAMiSSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR00694. thiM. 1 hit.

Sequencei

Sequence statusi: Complete.

A7NRF8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDTINQRIGE MLARVRATRP LIHHITNLVV MNDTANVTLH VGGLPVMAHD
60 70 80 90 100
VEEVAEMVTH AGALVLNVGT LSPDWVESML VAGRQANELD IPIVLDPVGA
110 120 130 140 150
GATQLRTMTN LKLLRSLHIG VVRGNGGEIG ALSGAGGEMR GVESIAAPEN
160 170 180 190 200
PLTAARTLAQ TYRTVVALTG ARDIITDGER GFIVSNGHIW LTTLTGTGCM
210 220 230 240 250
ATTMVAAFAA VERDYLLAAA GGLAMFGLAA ELAAEKAHGP ASFKTALFDQ
260 270
IYNLTPEQVA AGARIAELEW
Length:270
Mass (Da):28,365
Last modified:October 2, 2007 - v1
Checksum:iF957A2DC6CD02B9F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000804 Genomic DNA. Translation: ABU60154.1.
RefSeqiWP_012122575.1. NC_009767.1.
YP_001434172.1. NC_009767.1.

Genome annotation databases

EnsemblBacteriaiABU60154; ABU60154; Rcas_4122.
GeneIDi5541633.
KEGGirca:Rcas_4122.
PATRICi23347114. VBIRosCas91182_4592.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000804 Genomic DNA. Translation: ABU60154.1 .
RefSeqi WP_012122575.1. NC_009767.1.
YP_001434172.1. NC_009767.1.

3D structure databases

ProteinModelPortali A7NRF8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 383372.Rcas_4122.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABU60154 ; ABU60154 ; Rcas_4122 .
GeneIDi 5541633.
KEGGi rca:Rcas_4122.
PATRICi 23347114. VBIRosCas91182_4592.

Phylogenomic databases

eggNOGi COG2145.
HOGENOMi HOG000114352.
KOi K00878.
OMAi QTFTANV.
OrthoDBi EOG628F8M.

Enzyme and pathway databases

UniPathwayi UPA00060 ; UER00139 .
BioCyci RCAS383372:GH89-4177-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.20. 1 hit.
HAMAPi MF_00228. Thz_kinase.
InterProi IPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view ]
Pfami PF02110. HK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000513. Thz_kinase. 1 hit.
PRINTSi PR01099. HYETHTZKNASE.
SUPFAMi SSF53613. SSF53613. 1 hit.
TIGRFAMsi TIGR00694. thiM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13941 / HLO8.

Entry informationi

Entry nameiTHIM_ROSCS
AccessioniPrimary (citable) accession number: A7NRF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 2, 2007
Last modified: October 29, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3