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A7NRF8 (THIM_ROSCS) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name=TH kinase
Short name=Thz kinase
Gene names
Name:thiM
Ordered Locus Names:Rcas_4122
OrganismRoseiflexus castenholzii (strain DSM 13941 / HLO8) [Complete proteome] [HAMAP]
Taxonomic identifier383372 [NCBI]
Taxonomic lineageBacteriaChloroflexiChloroflexalesChloroflexaceaeRoseiflexus

Protein attributes

Sequence length270 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 270270Hydroxyethylthiazole kinase HAMAP-Rule MF_00228
PRO_0000336567

Sites

Binding site471Substrate; via amide nitrogen By similarity
Binding site1231ATP By similarity
Binding site1691ATP By similarity
Binding site1961Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
A7NRF8 [UniParc].

Last modified October 2, 2007. Version 1.
Checksum: F957A2DC6CD02B9F

FASTA27028,365
        10         20         30         40         50         60 
MDTINQRIGE MLARVRATRP LIHHITNLVV MNDTANVTLH VGGLPVMAHD VEEVAEMVTH 

        70         80         90        100        110        120 
AGALVLNVGT LSPDWVESML VAGRQANELD IPIVLDPVGA GATQLRTMTN LKLLRSLHIG 

       130        140        150        160        170        180 
VVRGNGGEIG ALSGAGGEMR GVESIAAPEN PLTAARTLAQ TYRTVVALTG ARDIITDGER 

       190        200        210        220        230        240 
GFIVSNGHIW LTTLTGTGCM ATTMVAAFAA VERDYLLAAA GGLAMFGLAA ELAAEKAHGP 

       250        260        270 
ASFKTALFDQ IYNLTPEQVA AGARIAELEW 

« Hide

References

[1]"Complete sequence of Roseiflexus castenholzii DSM 13941."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Thompson L.S., Brettin T., Bruce D., Detter J.C., Han C., Tapia R., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Mikhailova N., Bryant D.A., Hanada S., Tsukatani Y., Richardson P.
Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 13941 / HLO8.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000804 Genomic DNA. Translation: ABU60154.1.
RefSeqYP_001434172.1. NC_009767.1.

3D structure databases

ProteinModelPortalA7NRF8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING383372.Rcas_4122.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABU60154; ABU60154; Rcas_4122.
GeneID5541633.
KEGGrca:Rcas_4122.
PATRIC23347114. VBIRosCas91182_4592.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2145.
HOGENOMHOG000114352.
KOK00878.
OMAQTFTANV.
OrthoDBEOG628F8M.

Enzyme and pathway databases

BioCycRCAS383372:GH89-4177-MONOMER.
UniPathwayUPA00060; UER00139.

Family and domain databases

Gene3D3.40.1190.20. 1 hit.
HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
SUPFAMSSF53613. SSF53613. 1 hit.
TIGRFAMsTIGR00694. thiM. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTHIM_ROSCS
AccessionPrimary (citable) accession number: A7NRF8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 2, 2007
Last modified: June 11, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways