A7NR97 (A7NR97_ROSCS) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Non-canonical purine NTP pyrophosphatase HAMAP MF_01405
EC=3.6.1.19 HAMAP MF_01405

Alternative name(s):
Non-standard purine NTP pyrophosphatase HAMAP MF_01405
Nucleoside-triphosphate diphosphatase HAMAP MF_01405
Nucleoside-triphosphate pyrophosphatase HAMAP MF_01405

Gene names

Ordered Locus Names:

Rcas_4061

Organism

Roseiflexus castenholzii (strain DSM 13941 / HLO8) [Complete proteome] [HAMAP] EMBL ABU60093.1

Taxonomic identifier

383372 [NCBI]

Taxonomic lineage

Bacteria › Chloroflexi › Chloroflexales › Chloroflexaceae › Roseiflexus

Protein attributes

Sequence length	204 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions By similarity. HAMAP MF_01405
Catalytic activity	A nucleoside triphosphate + H2O = a nucleotide + diphosphate. HAMAP MF_01405 SAAS SAAS020922
Cofactor	Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese By similarity. HAMAP MF_01405 SAAS SAAS020922
Subunit structure	Homodimer By similarity. HAMAP MF_01405 SAAS SAAS020922
Sequence similarities	Belongs to the HAM1 NTPase family. HAMAP MF_01405

Ontologies

Keywords
Biological process	Nucleotide metabolism HAMAP MF_01405 SAAS SAAS020922
Ligand	Magnesium HAMAP MF_01405 SAAS SAAS020922 Manganese HAMAP MF_01405 SAAS SAAS020922 Metal-binding HAMAP MF_01405 SAAS SAAS020922 Nucleotide-binding HAMAP MF_01405 SAAS SAAS020922
Molecular function	Hydrolase HAMAP MF_01405 SAAS SAAS020922
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro nucleoside-triphosphate diphosphatase activity Inferred from electronic annotation. Source: HAMAP nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Region	8 – 13	6	Substrate binding By similarity HAMAP MF_01405
	Region	70 – 71	2	Substrate binding By similarity HAMAP MF_01405
Sites
	Metal binding	41	1	Magnesium or manganese By similarity HAMAP MF_01405
	Metal binding	70	1	Magnesium or manganese By similarity HAMAP MF_01405
	Binding site	156	1	Substrate By similarity HAMAP MF_01405
	Binding site	176	1	Substrate By similarity HAMAP MF_01405
	Binding site	182	1	Substrate By similarity HAMAP MF_01405

Sequences

	Sequence		Length	Mass (Da)
	A7NR97 [UniParc]. Last modified October 2, 2007. Version 1. Checksum: DFF6608A7F87204B	FASTA	204	22,282
	10 20 30 40 50 60 MPRLLIATTN PGKLREYAAI FADLPLDLCT LADLGIQDDV EETGATFAEN ARIKAEYYAQ 70 80 90 100 110 120 RSGLPTLADD SGLEVAALGG EPGVRSARYA GPEATDAERN AFLLRKLEHV PFHARLARFV 130 140 150 160 170 180 CVIALALPGG PIEFVEGVLP GVIEFEPKGH YGFGYDPIFY VLDEDATLAE LPPERKNQIS 190 200 HRANAARAAR DVLRRWLDEG WPGP

References

[1]

"Complete sequence of Roseiflexus castenholzii DSM 13941." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Thompson L.S., Brettin T., Bruce D., Detter J.C., Han C., Tapia R., Schmutz J., Larimer F., Land M., Hauser L. , Kyrpides N., Mikhailova N., Bryant D.A., Hanada S., Tsukatani Y., Richardson P. Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 13941 / HLO8.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000804 Genomic DNA. Translation: ABU60093.1.
RefSeq	YP_001434111.1. NC_009767.1.
3D structure databases
ProteinModelPortal	A7NR97.
ModBase	Search...
Protein-protein interaction databases
STRING	A7NR97.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5541572.
GenomeReviews	Gene locus Rcas_4061 in contig CP000804_GR.
KEGG	rca:Rcas_4061.
PATRIC	23346992. VBIRosCas91182_4531.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0127.
HOGENOM	HBG697237.
OMA	GVYTADW.
ProtClustDB	CLSK974075.
Enzyme and pathway databases
BioCyc	RCAS383372:RCAS_4061-MONOMER.
Family and domain databases
HAMAP	MF_01405. Non_canon_purine_NTPase. [Tree]
InterPro	IPR002637. Ham1p-like. IPR020922. Nucleoside-triphosphatase. [Graphical view]
KO	K02428.
PANTHER	PTHR11067. Ham1p_like. 1 hit.
Pfam	PF01725. Ham1p_like. 1 hit. [Graphical view]
TIGRFAMs	TIGR00042. TIGR00042. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A7NR97_ROSCS

Accession

Primary (citable) accession number: A7NR97

Entry history

Integrated into UniProtKB/TrEMBL:	October 2, 2007
Last sequence update:	October 2, 2007
Last modified:	December 14, 2011
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)