A7NPB5 (ARGB_ROSCS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetylglutamate kinase
EC=2.7.2.8

Alternative name(s):
N-acetyl-L-glutamate 5-phosphotransferase
NAG kinase
Short name=AGK

Gene names

Name:	argB
Ordered Locus Names:	Rcas_3361

Organism

Roseiflexus castenholzii (strain DSM 13941 / HLO8) [Complete proteome] [HAMAP]

Taxonomic identifier

383372 [NCBI]

Taxonomic lineage

Bacteria › Chloroflexi › Chloroflexales › Chloroflexaceae › Roseiflexus

Protein attributes

Sequence length	259 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. HAMAP MF_00082_B
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. HAMAP MF_00082_B
Subcellular location	Cytoplasm By similarity HAMAP MF_00082_B.
Sequence similarities	Belongs to the acetylglutamate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetylglutamate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 259	259	Acetylglutamate kinase HAMAP MF_00082_B		PRO_0000335658
Regions
	Region	46 – 47	2	Substrate binding By similarity
Sites
	Binding site	68	1	Substrate By similarity
	Binding site	162	1	Substrate By similarity
	Site	14	1	Transition state stabilizer By similarity
	Site	221	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7NPB5 [UniParc]. Last modified October 2, 2007. Version 1. Checksum: 1CACF0B26BD15814	FASTA	259	26,833
	10 20 30 40 50 60 MTDPVSRQPT LVIKVGGNEL DDATFVKELA RIVAAMRPIP TLVHGGGKEI GVLQETLGSA 70 80 90 100 110 120 PRFVGGLRYT DATALTAAEM VLCGSVSTRL VAALIVAGAD ALGISGVDRG LIRVVKQEHP 130 140 150 160 170 180 AGDLGRVGRP TAVRSEVLHE LLNHDVIPVI APIALGFDGP YNVNADEAAG AIAAALGADE 190 200 210 220 230 240 VVFVTNVPGV LVNGDVMPRL TRHEIEHLIA DGTISGGMIP KVRAALTALD AGVRAARITN 250 LEGMLEHGTI IIAEGEVHE

References

[1]

"Complete sequence of Roseiflexus castenholzii DSM 13941." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Thompson L.S., Brettin T., Bruce D., Detter J.C., Han C., Tapia R., Schmutz J., Larimer F., Land M., Hauser L. , Kyrpides N., Mikhailova N., Bryant D.A., Hanada S., Tsukatani Y., Richardson P. Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 13941 / HLO8.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000804 Genomic DNA. Translation: ABU59411.1.
RefSeq	YP_001433429.1. NC_009767.1.
3D structure databases
ProteinModelPortal	A7NPB5.
ModBase	Search...
Protein-protein interaction databases
STRING	A7NPB5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5540860.
GenomeReviews	Gene locus Rcas_3361 in contig CP000804_GR.
KEGG	rca:Rcas_3361.
PATRIC	23345416. VBIRosCas91182_3755.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0548.
HOGENOM	HBG497643.
OMA	GGCLVDD.
ProtClustDB	CLSK975146.
Enzyme and pathway databases
BioCyc	RCAS383372:RCAS_3361-MONOMER.
Family and domain databases
HAMAP	MF_00082_B. ArgB_B. [Tree]
InterPro	IPR004662. AcgluKinase. IPR001048. Asp/Glu/Uridylate_kinase. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit.
KO	K00930.
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000728. NAGK. 1 hit.
SUPFAM	SSF53633. Aa_kinase. 1 hit.
TIGRFAMs	TIGR00761. ArgB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARGB_ROSCS

Accession

Primary (citable) accession number: A7NPB5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	October 2, 2007
Last modified:	January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program