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Protein

Xylose isomerase

Gene

xylA

Organism
Roseiflexus castenholzii (strain DSM 13941 / HLO8)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei56UniRule annotation1
Active sitei59UniRule annotation1
Metal bindingi183Magnesium 1UniRule annotation1
Metal bindingi219Magnesium 1UniRule annotation1
Metal bindingi219Magnesium 2UniRule annotation1
Metal bindingi222Magnesium 2UniRule annotation1
Metal bindingi247Magnesium 1UniRule annotation1
Metal bindingi289Magnesium 1UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotationImported

Keywords - Biological processi

Carbohydrate metabolism, Pentose shuntUniRule annotationSAAS annotation, Xylose metabolismUniRule annotationSAAS annotation

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomeraseUniRule annotationSAAS annotation (EC:5.3.1.5UniRule annotationSAAS annotation)
Gene namesi
Name:xylAUniRule annotation
Ordered Locus Names:Rcas_2618Imported
OrganismiRoseiflexus castenholzii (strain DSM 13941 / HLO8)Imported
Taxonomic identifieri383372 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesRoseiflexineaeRoseiflexaceaeRoseiflexus
Proteomesi
  • UP000000263 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi383372.Rcas_2618.

Structurei

3D structure databases

ProteinModelPortaliA7NMC9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 253AP_endonuc_2InterPro annotationAdd BLAST211

Sequence similaritiesi

Belongs to the xylose isomerase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105C93. Bacteria.
COG2115. LUCA.
HOGENOMiHOG000022596.
KOiK01805.
OMAiGCMRTYL.
OrthoDBiPOG091H07LC.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A. 1 hit.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013453. XylA_actinobac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02631. xylA_Arthro. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7NMC9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDMYEPKPE HKFTFGLWTV GNIGRDPFGE PVRHPLSPVE IVHLLADVGA
60 70 80 90 100
YGVNFHDNDL IPIDATPADR DRILREFKAA LQETGLVVPM ATTNLFADPV
110 120 130 140 150
FKDGAFTSND PKVRAYALQK TMRAIDLGVE CGAKVYVFWG GREGVESDAA
160 170 180 190 200
KDPQEGLKRY REVINFLCAY VKDQGYDLKF ALEPKPNEPR GDIYLATVGH
210 220 230 240 250
ALAFINTLDH PDMVGLNPEV AHETMAGLNF LHGVAQAWDA GKLFHIDLND
260 270 280 290 300
QVIGRYDQDF RFGAVNLKAA FFLVRFLENV GYQGSRHFDA HAYRTEDYEG
310 320 330 340 350
VKTFARGCMR TYLILKEKAR RFDGDAEIQA LLAEITADDG TMAPFQGGYS
360 370 380
RDKADALKAH PFDRVALGRR GLAYERLDQL TNELLLGVR
Length:389
Mass (Da):43,519
Last modified:October 2, 2007 - v1
Checksum:i2FB80952CBABBDCB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000804 Genomic DNA. Translation: ABU58691.1.
RefSeqiWP_012121115.1. NC_009767.1.

Genome annotation databases

EnsemblBacteriaiABU58691; ABU58691; Rcas_2618.
KEGGirca:Rcas_2618.
PATRICi23343745. VBIRosCas91182_2937.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000804 Genomic DNA. Translation: ABU58691.1.
RefSeqiWP_012121115.1. NC_009767.1.

3D structure databases

ProteinModelPortaliA7NMC9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi383372.Rcas_2618.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABU58691; ABU58691; Rcas_2618.
KEGGirca:Rcas_2618.
PATRICi23343745. VBIRosCas91182_2937.

Phylogenomic databases

eggNOGiENOG4105C93. Bacteria.
COG2115. LUCA.
HOGENOMiHOG000022596.
KOiK01805.
OMAiGCMRTYL.
OrthoDBiPOG091H07LC.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A. 1 hit.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013453. XylA_actinobac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02631. xylA_Arthro. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA7NMC9_ROSCS
AccessioniPrimary (citable) accession number: A7NMC9
Entry historyi
Integrated into UniProtKB/TrEMBL: October 2, 2007
Last sequence update: October 2, 2007
Last modified: November 30, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.