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A7NLU3

- ACDH_ROSCS

UniProt

A7NLU3 - ACDH_ROSCS

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Protein

Acetaldehyde dehydrogenase

Gene
Rcas_2411
Organism
Roseiflexus castenholzii (strain DSM 13941 / HLO8)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei128 – 1281Acyl-thioester intermediate By similarity
Binding sitei278 – 2781NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 164NAD By similarity
Nucleotide bindingi159 – 1679NAD By similarity

GO - Molecular functioni

  1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
  2. NAD binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciRCAS383372:GH89-2436-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase (EC:1.2.1.10)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]
Gene namesi
Ordered Locus Names:Rcas_2411
OrganismiRoseiflexus castenholzii (strain DSM 13941 / HLO8)
Taxonomic identifieri383372 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesRoseiflexineaeRoseiflexaceaeRoseiflexus
ProteomesiUP000000263: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 305305Acetaldehyde dehydrogenaseUniRule annotationPRO_0000387734Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi383372.Rcas_2411.

Structurei

3D structure databases

ProteinModelPortaliA7NLU3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK04073.
OMAiHQGNVNM.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

A7NLU3-1 [UniParc]FASTAAdd to Basket

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MGDETIKVAI LGSGNIGTDL MYKLLDCPAS MELVLLAGID PNSEGLARAR    50
ALGVAASAQG IDAVLEHPDI QIVFDATSAK AHVRHAKLLR ETGRTAIDLT 100
PAARGPYVVP PVNLRQHLDA PNVNLITCGG QATIPLVYAV SRVTPVRYAE 150
IVSTVASRSA GPGTRQNIDE FTFTTAHGLE VIGGAQQGKA IIILNPAEPP 200
ILMRNTVYAL PEDDFDPAQV RDSIEAMVAE VQQYVPGYRL KNPPVFDMRD 250
TPWGRKSAVT VLLEVEGAGH FLPTYAGNLD IMTASARRVG DVFARHLLSR 300
REVAV 305
Length:305
Mass (Da):32,687
Last modified:October 2, 2007 - v1
Checksum:iDFCA758E9E7000E0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000804 Genomic DNA. Translation: ABU58491.1.
RefSeqiWP_012120915.1. NC_009767.1.
YP_001432509.1. NC_009767.1.

Genome annotation databases

EnsemblBacteriaiABU58491; ABU58491; Rcas_2411.
GeneIDi5539892.
KEGGirca:Rcas_2411.
PATRICi23343301. VBIRosCas91182_2716.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000804 Genomic DNA. Translation: ABU58491.1 .
RefSeqi WP_012120915.1. NC_009767.1.
YP_001432509.1. NC_009767.1.

3D structure databases

ProteinModelPortali A7NLU3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 383372.Rcas_2411.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABU58491 ; ABU58491 ; Rcas_2411 .
GeneIDi 5539892.
KEGGi rca:Rcas_2411.
PATRICi 23343301. VBIRosCas91182_2716.

Phylogenomic databases

eggNOGi COG4569.
HOGENOMi HOG000052149.
KOi K04073.
OMAi HQGNVNM.
OrthoDBi EOG6H1PXH.

Enzyme and pathway databases

BioCyci RCAS383372:GH89-2436-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13941 / HLO8.

Entry informationi

Entry nameiACDH_ROSCS
AccessioniPrimary (citable) accession number: A7NLU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: October 2, 2007
Last modified: September 3, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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