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A7NLL2

- SYE_ROSCS

UniProt

A7NLL2 - SYE_ROSCS

Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Roseiflexus castenholzii (strain DSM 13941 / HLO8)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (02 Oct 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

    Catalytic activityi

    ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei264 – 2641ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP
    3. tRNA binding Source: InterPro

    GO - Biological processi

    1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRCAS383372:GH89-2345-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
    Alternative name(s):
    Glutamyl-tRNA synthetaseUniRule annotation
    Short name:
    GluRSUniRule annotation
    Gene namesi
    Name:gltXUniRule annotation
    Ordered Locus Names:Rcas_2320
    OrganismiRoseiflexus castenholzii (strain DSM 13941 / HLO8)
    Taxonomic identifieri383372 [NCBI]
    Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesRoseiflexineaeRoseiflexaceaeRoseiflexus
    ProteomesiUP000000263: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 507507Glutamate--tRNA ligasePRO_1000074328Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi383372.Rcas_2320.

    Structurei

    3D structure databases

    ProteinModelPortaliA7NLL2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi14 – 2411"HIGH" regionAdd
    BLAST
    Motifi261 – 2655"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0008.
    HOGENOMiHOG000252720.
    KOiK01885.
    OMAiDSHEHHA.
    OrthoDBiEOG6DRPF7.

    Family and domain databases

    Gene3Di1.10.10.350. 1 hit.
    1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPiMF_00022_B. Glu_tRNA_synth_B.
    InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
    IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
    IPR001412. aa-tRNA-synth_I_CS.
    IPR004527. Glu-tRNA-ligase_bac/mito.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR10119. PTHR10119. 1 hit.
    PfamiPF00749. tRNA-synt_1c. 1 hit.
    [Graphical view]
    PRINTSiPR00987. TRNASYNTHGLU.
    SUPFAMiSSF48163. SSF48163. 1 hit.
    TIGRFAMsiTIGR00464. gltX_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A7NLL2-1 [UniParc]FASTAAdd to Basket

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    MGVIQGPVRV RFAPSPTGYL HIGGVRTALF NWLFARHYGG QFILRIEDTD    50
    EKRYVPGSAD DLMASLRWVG IEWDEGPDIG GPHAPYVQSL RYEAGIYRPF 100
    VEQLLESGHA YLSFTTEEEL ERMRAEAQAR GVKAFRFRGP ERDWPLDRQR 150
    EMAATGRPYT VRLKTPTEGV TAFRDLVRGG ERIEFKNEEL YDIVLVKSSG 200
    MPVYHLAHLV DDHLMRMTHV LRSDEWVAST PYHVLLYQAF GWDPPAFAHL 250
    PPILRQDGRG KLSKRTDDVA ANRFWERGYL PDAMFNYLAL QGWSYDGYTE 300
    IMSREELIER FTLDRVQPSP ARWNPEKLLD MNGIYIRRLT TEQLVDAMAP 350
    FLARAGLIGN PPTPDERAYL LQLAPLIHER LKELGEAPEL LEFFFRDVTD 400
    YDPQALIPKK MDASTTVAAL QAARDRLASL EPWTHDRLEA ELRALGEELG 450
    LKPGQLFGAL RVAATGRTVA PPLFDTLAAL GKPRTLRRLE AAISVLAAAH 500
    AEVKGQS 507
    Length:507
    Mass (Da):57,432
    Last modified:October 2, 2007 - v1
    Checksum:i4700BA1F36E79FB4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000804 Genomic DNA. Translation: ABU58403.1.
    RefSeqiWP_012120827.1. NC_009767.1.
    YP_001432421.1. NC_009767.1.

    Genome annotation databases

    EnsemblBacteriaiABU58403; ABU58403; Rcas_2320.
    GeneIDi5539801.
    KEGGirca:Rcas_2320.
    PATRICi23343101. VBIRosCas91182_2616.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000804 Genomic DNA. Translation: ABU58403.1 .
    RefSeqi WP_012120827.1. NC_009767.1.
    YP_001432421.1. NC_009767.1.

    3D structure databases

    ProteinModelPortali A7NLL2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 383372.Rcas_2320.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABU58403 ; ABU58403 ; Rcas_2320 .
    GeneIDi 5539801.
    KEGGi rca:Rcas_2320.
    PATRICi 23343101. VBIRosCas91182_2616.

    Phylogenomic databases

    eggNOGi COG0008.
    HOGENOMi HOG000252720.
    KOi K01885.
    OMAi DSHEHHA.
    OrthoDBi EOG6DRPF7.

    Enzyme and pathway databases

    BioCyci RCAS383372:GH89-2345-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.350. 1 hit.
    1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPi MF_00022_B. Glu_tRNA_synth_B.
    InterProi IPR008925. aa-tRNA-synth_I_codon-bd.
    IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
    IPR001412. aa-tRNA-synth_I_CS.
    IPR004527. Glu-tRNA-ligase_bac/mito.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR10119. PTHR10119. 1 hit.
    Pfami PF00749. tRNA-synt_1c. 1 hit.
    [Graphical view ]
    PRINTSi PR00987. TRNASYNTHGLU.
    SUPFAMi SSF48163. SSF48163. 1 hit.
    TIGRFAMsi TIGR00464. gltX_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 13941 / HLO8.

    Entry informationi

    Entry nameiSYE_ROSCS
    AccessioniPrimary (citable) accession number: A7NLL2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: October 2, 2007
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3