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Protein

Dihydrolipoyl dehydrogenase

Gene

Rcas_2104

Organism
Roseiflexus castenholzii (strain DSM 13941 / HLO8)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Miscellaneous

The active site is a redox-active disulfide bond.UniRule annotation

Catalytic activityi

Protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH.UniRule annotation

Cofactori

FADUniRule annotationNote: Binds 1 FAD per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandFADUniRule annotation, Flavoprotein, NADUniRule annotation

Enzyme and pathway databases

BioCyciRCAS383372:GH89-2073-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrolipoyl dehydrogenaseUniRule annotation (EC:1.8.1.4UniRule annotation)
Gene namesi
Ordered Locus Names:Rcas_2104Imported
OrganismiRoseiflexus castenholzii (strain DSM 13941 / HLO8)Imported
Taxonomic identifieri383372 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesRoseiflexineaeRoseiflexaceaeRoseiflexus
Proteomesi
  • UP000000263 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Interactioni

Protein-protein interaction databases

STRINGi383372.Rcas_2104.

Structurei

3D structure databases

ProteinModelPortaliA7NL19.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 331FAD/NAD-binding_domInterPro annotationAdd BLAST326
Domaini351 – 460Pyr_redox_dimInterPro annotationAdd BLAST110

Sequence similaritiesi

Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.UniRule annotation

Keywords - Domaini

Redox-active centerUniRule annotation

Phylogenomic databases

eggNOGiENOG4107QN2. Bacteria.
COG1249. LUCA.
HOGENOMiHOG000276708.
KOiK00382.
OMAiTMSEAVM.
OrthoDBiPOG091H0239.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
3.50.50.60. 1 hit.
InterProiView protein in InterPro
IPR023753. FAD/NAD-binding_dom.
IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR006258. Lipoamide_DH.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR012999. Pyr_OxRdtase_I_AS.
PfamiView protein in Pfam
PF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
SUPFAMiSSF51905. SSF51905. 1 hit.
SSF55424. SSF55424. 1 hit.
TIGRFAMsiTIGR01350. lipoamide_DH. 1 hit.
PROSITEiView protein in PROSITE
PS00076. PYRIDINE_REDOX_1. 1 hit.

Sequencei

Sequence statusi: Complete.

A7NL19-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDTLYDVVV VGGGPGGYVA AIRAAQLGLK TAVVERQAMG GVCLNVGCIP
60 70 80 90 100
TKALLHTADL LEELREAKRF GVVVEGVSLD WEATLRQKDT VVKTMTSGVS
110 120 130 140 150
FLMKKNKVDV INGFARLAGR GQVAISTPEG QHRTVTAKNI IVAVGARPRE
160 170 180 190 200
IPAIGAVFDN DRILSSTGGL SIPSVPKSLL VVGAGAIGVE FASMYRSFGA
210 220 230 240 250
EVTLVEMLPR VVPLEDEEVS AELARALNRR GIKVFAGSKL NHLEKIDGGV
260 270 280 290 300
IARLVDAQGA EHALTFERAL VGVGIVPNTG DIGLEEVGVA LDQRGFIKVD
310 320 330 340 350
DYMRTNVEGI YAIGDCAVTT PWLAHKASAE GIIAAETIAG HHTQPLDYGK
360 370 380 390 400
IPSCTYCNPE IASVGLTEAK AREQGYDVKI GKFAFTGNGK ATILGQRQGF
410 420 430 440 450
VKIVADKQYD EVLGVHMIGP RVTELIAEGG LALSHEATAE SIMRTVHAHP
460 470
TLYEAIVEAA HAAAEGAAIH M
Length:471
Mass (Da):49,741
Last modified:October 2, 2007 - v1
Checksum:i2DE3F36F5986ADEE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000804 Genomic DNA. Translation: ABU58189.1.
RefSeqiWP_012120613.1. NC_009767.1.

Genome annotation databases

EnsemblBacteriaiABU58189; ABU58189; Rcas_2104.
KEGGirca:Rcas_2104.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiA7NL19_ROSCS
AccessioniPrimary (citable) accession number: A7NL19
Entry historyiIntegrated into UniProtKB/TrEMBL: October 2, 2007
Last sequence update: October 2, 2007
Last modified: June 7, 2017
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported