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A7NKY6 (PGK_ROSCS) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase

EC=2.7.2.3
Gene names
Name:pgk
Ordered Locus Names:Rcas_2070
OrganismRoseiflexus castenholzii (strain DSM 13941 / HLO8) [Complete proteome] [HAMAP]
Taxonomic identifier383372 [NCBI]
Taxonomic lineageBacteriaChloroflexiChloroflexalesChloroflexaceaeRoseiflexus

Protein attributes

Sequence length395 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00145

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00145.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycolysis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 395395Phosphoglycerate kinase HAMAP-Rule MF_00145
PRO_1000076601

Regions

Nucleotide binding351 – 3544ATP By similarity
Region21 – 233Substrate binding By similarity
Region59 – 624Substrate binding By similarity

Sites

Binding site361Substrate By similarity
Binding site1201Substrate By similarity
Binding site1531Substrate By similarity
Binding site2031ATP By similarity
Binding site3251ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A7NKY6 [UniParc].

Last modified October 2, 2007. Version 1.
Checksum: 23392FD7D7E59CDE

FASTA39541,559
        10         20         30         40         50         60 
MAKKTIRDID WSGKRALVRV DFNVPLENGQ ITDDTRIRAA LPTIRYLLEH GAAVILMSHL 

        70         80         90        100        110        120 
GRPKNKVVES MRLAPVVARL AELLPEAKAV KGSQATTGPA AEAAARDLKP GEVLVLENTR 

       130        140        150        160        170        180 
FDPREEANDE SMARELAKLG DVYVNDAFGS AHRAHASTEG VARFLPAVAG FLMEAELAAL 

       190        200        210        220        230        240 
QGALENPARP FVTIIGGAKI SDKIGVIENL LGKVDALLIG GGMANTFLLA QGHEMGDSLV 

       250        260        270        280        290        300 
EPDSAPIAKS LLDQAAQRGV RLMLPTDVVI ADAFSADANR KVVPVGEIPP GWRALDIGPE 

       310        320        330        340        350        360 
TIRAYTEVIT GAQTVIWNGP MGVFELAPFA EGTRAIAQAM ANCPGMTIIG GGDSVAAIEQ 

       370        380        390 
MGLADKIRHI STGGGASLEL LEGRILPGVA ALNDA 

« Hide

References

[1]"Complete sequence of Roseiflexus castenholzii DSM 13941."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Thompson L.S., Brettin T., Bruce D., Detter J.C., Han C., Tapia R., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Mikhailova N., Bryant D.A., Hanada S., Tsukatani Y., Richardson P.
Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 13941 / HLO8.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000804 Genomic DNA. Translation: ABU58156.1.
RefSeqYP_001432174.1. NC_009767.1.

3D structure databases

ProteinModelPortalA7NKY6.
SMRA7NKY6. Positions 1-394.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING383372.Rcas_2070.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABU58156; ABU58156; Rcas_2070.
GeneID5539550.
KEGGrca:Rcas_2070.
PATRIC23342539. VBIRosCas91182_2336.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0126.
HOGENOMHOG000227108.
KOK00927.
OMAFGLADKM.
OrthoDBEOG64N9Z0.
ProtClustDBPRK00073.

Enzyme and pathway databases

BioCycRCAS383372:GH89-2094-MONOMER.
UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
ProtoNetSearch...

Entry information

Entry namePGK_ROSCS
AccessionPrimary (citable) accession number: A7NKY6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 2, 2007
Last modified: February 19, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways