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A7NKV1

- GSA_ROSCS

UniProt

A7NKV1 - GSA_ROSCS

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Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene
hemL, Rcas_2033
Organism
Roseiflexus castenholzii (strain DSM 13941 / HLO8)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro

GO - Biological processi

  1. chlorophyll biosynthetic process Source: UniProtKB-HAMAP
  2. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Chlorophyll biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciRCAS383372:GH89-2055-MONOMER.
UniPathwayiUPA00251; UER00317.
UPA00668.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase (EC:5.4.3.8)
Short name:
GSA
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name:
GSA-AT
Gene namesi
Name:hemL
Ordered Locus Names:Rcas_2033
OrganismiRoseiflexus castenholzii (strain DSM 13941 / HLO8)
Taxonomic identifieri383372 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesRoseiflexineaeRoseiflexaceaeRoseiflexus
ProteomesiUP000000263: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotationPRO_1000201031Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei267 – 2671N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi383372.Rcas_2033.

Structurei

3D structure databases

ProteinModelPortaliA7NKV1.
SMRiA7NKV1. Positions 1-424.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0001.
HOGENOMiHOG000020210.
KOiK01845.
OMAiRAIKPYP.
OrthoDBiEOG6QVRHN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7NKV1-1 [UniParc]FASTAAdd to Basket

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MKTYRSESLF AEARSLFPGG VNSPVRAFRA VGGAPRFIAR GEGAFLVDVD    50
GNRYIDYVLS WGPLILGHAH PNVVAAIAEQ AAHGTSFGAP TELESELARL 100
ITQAMPSVEM VRFVSSGTEA AMSALRLARA ATRRDKVIKF AGCYHGHFDG 150
FLVQAGSGVA TLGLPDSPGV TAATAASTLT APYNDLDAVE SLLKANPGEV 200
AAIAVEPVAG NMGLVLPQPG FLEGLRRLAD EHGALLIFDE VMTGFRVGYG 250
GAQGKYGITP DLTCLGKVIG GGLPAAAYGG RRDLMELIAP AGPVYQAGTL 300
SGNPLAMAAG AATLRAIRAP GVFEQLERAA AMLCSGFEHA AAEADIALRT 350
AYAGSMWGFF FTDEPVVDYV SAKKSDTQRY AQFFHAMLER GIYLAPAQFE 400
ASFVSLAHSD ALIQETIAAA ADALRSIQNA ARKG 434
Length:434
Mass (Da):45,413
Last modified:October 2, 2007 - v1
Checksum:iFF65068B3F7A010D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000804 Genomic DNA. Translation: ABU58121.1.
RefSeqiWP_012120545.1. NC_009767.1.
YP_001432139.1. NC_009767.1.

Genome annotation databases

EnsemblBacteriaiABU58121; ABU58121; Rcas_2033.
GeneIDi5539511.
KEGGirca:Rcas_2033.
PATRICi23342455. VBIRosCas91182_2296.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000804 Genomic DNA. Translation: ABU58121.1 .
RefSeqi WP_012120545.1. NC_009767.1.
YP_001432139.1. NC_009767.1.

3D structure databases

ProteinModelPortali A7NKV1.
SMRi A7NKV1. Positions 1-424.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 383372.Rcas_2033.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABU58121 ; ABU58121 ; Rcas_2033 .
GeneIDi 5539511.
KEGGi rca:Rcas_2033.
PATRICi 23342455. VBIRosCas91182_2296.

Phylogenomic databases

eggNOGi COG0001.
HOGENOMi HOG000020210.
KOi K01845.
OMAi RAIKPYP.
OrthoDBi EOG6QVRHN.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .
UPA00668 .
BioCyci RCAS383372:GH89-2055-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00713. hemL. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13941 / HLO8.

Entry informationi

Entry nameiGSA_ROSCS
AccessioniPrimary (citable) accession number: A7NKV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: October 2, 2007
Last modified: September 3, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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